2025
Progesterone restores blood-brain barrier and memory after chronic cerebral hypoperfusion in male rats
Espadín M, Cervantes M, Coyoy-Salgado A, Espinosa-Garcia C, Gómez-González B, Moralí G. Progesterone restores blood-brain barrier and memory after chronic cerebral hypoperfusion in male rats. Brain Behavior And Immunity Integrative 2025, 11: 100132. DOI: 10.1016/j.bbii.2025.100132.Peer-Reviewed Original ResearchChronic cerebral hypoperfusionBlood-brain barrierTight junction proteinsSpatial learningMale ratsJunction proteinsCerebral hypoperfusionSprague-Dawley ratsBlood-brain barrier dysfunctionEffects of P4Inflammatory factor levelsAge-related alterationsBrain injury modelInjury modelInflammation factorsRatsHypoperfusionNeuroprotective effectsFactor levelsIntroduction AgingProgesteroneMemoryAlterationsBrainDays
2024
Characterizing an Underdiagnosed Condition: Hemophilia in Females
Restrepo V, Prozora S, Louizos E, Van Doren L, Bona R. Characterizing an Underdiagnosed Condition: Hemophilia in Females. Blood 2024, 144: 2584-2584. DOI: 10.1182/blood-2024-210735.Peer-Reviewed Original ResearchPost-partum hemorrhageHeavy menstrual bleedingIron deficiency anemiaLow factor levelsClotting factor levelsHemophilia treatment centersHaemophilia carriersBlood transfusionHemophilia RegistryFactor deficiencyFactor levelsRates of heavy menstrual bleedingFrequency of blood transfusionLife-threatening bleedingFactor replacement therapyManagement of HCAnti-fibrinolytic agentDiagnosis of HCAge of diagnosisHemophilia B carriersYale-New Haven HospitalHealthcare disparitiesNormal factor VIIIHemophilia A carriersFactor activity
2023
Inherited and Acquired Thrombophilias
Abhari P, Paidas M. Inherited and Acquired Thrombophilias. 2023, 114-122. DOI: 10.1002/9781119636540.ch14.Peer-Reviewed Original ResearchThrombophilic conditionsTransient hypercoagulable stateCoagulation factor levelsContext of pregnancyAcquired ThrombophiliaAntifibrinolytic systemsNeonatal outcomesProthrombotic tendencyHypercoagulable stateHormonal changesClinical consequencesThrombotic conditionsFactor levelsPregnancyThrombophiliaMaternalDiagnosis
2022
Low Molecular Weight Heparin, Unfractionated Heparin and Neuraxial Anaesthesia
Combs D, Leffert L. Low Molecular Weight Heparin, Unfractionated Heparin and Neuraxial Anaesthesia. 2022, 329-335. DOI: 10.1007/978-3-030-72487-0_49.Peer-Reviewed Original Research
2021
Toxicological analysis and efficacy of 2-phenylchromone on mycobacteria viability and inflammatory response induced by Mycobacterium bovis
Moreira F, Radai J, de Souza V, Berno C, de Araújo F, Andrade-Silva M, Oliveira R, Arena A, de Oliveira Henriques M, Kassuya C, Croda J. Toxicological analysis and efficacy of 2-phenylchromone on mycobacteria viability and inflammatory response induced by Mycobacterium bovis. Phytomedicine Plus 2021, 1: 100117. DOI: 10.1016/j.phyplu.2021.100117.Peer-Reviewed Original ResearchInflammatory responseOral treatmentSplenic phagocytosisTumor necrosis factor levelsAnti-inflammatory actionNecrosis factor levelsAcute oral toxicity testAnti-inflammatory propertiesMycobacterium bovisMycobacterium tuberculosis strainsDifferential leukocyte countsOral toxicity testPleurisy inductionCytokine productionPleurisy modelLeukocyte countMinimum inhibitory concentrationMycobacteria infectionMycobacteria viabilityPleural exudatesLeukocyte migrationTuberculosis strainsVivo modelToxicity signsFactor levelsThe mediating effect of brain-derived neurotrophic factor levels on childhood trauma and psychiatric symptoms in patients with first-episode schizophrenia
Wang L, Yin Y, Zhou Y, Huang J, Zhang P, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Li CR, Tian B, Tian L, Hong L, Tan Y. The mediating effect of brain-derived neurotrophic factor levels on childhood trauma and psychiatric symptoms in patients with first-episode schizophrenia. Australian & New Zealand Journal Of Psychiatry 2021, 56: 828-835. PMID: 34263656, DOI: 10.1177/00048674211031478.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factor levelsSerum brain-derived neurotrophic factor (BDNF) levelsNeurotrophic factor levelsFirst-episode schizophreniaQuestionnaire total scoreNegative Syndrome Scale total scoreChildhood Trauma Questionnaire total scoreScale total scoreNegative Syndrome ScaleFactor levelsTotal scoreChildhood traumaHealthy controlsLower serum brain-derived neurotrophic factor levelsAbnormal brain-derived neurotrophic factorChildhood traumatic experiencesSyndrome ScaleBrain-derived neurotrophic factorPathogenesis of schizophreniaEmotional neglectEnzyme-linked immunosorbentSevere childhood traumaChildhood Trauma QuestionnaireClinical symptomsNeurotrophic factor
2020
The critical need for postmarketing surveillance in gene therapy for haemophilia
Konkle B, Recht M, Hilger A, Marks P. The critical need for postmarketing surveillance in gene therapy for haemophilia. Haemophilia 2020, 27: 126-131. PMID: 32495492, DOI: 10.1111/hae.13972.Peer-Reviewed Original ResearchConceptsGene therapyAdeno-associated viral vectorsGoal of gene therapyPhase 3 trialPostmarketing surveillanceDeficient coagulation factorDurability of efficacyGene therapy outcomesGene therapy productsCoagulation factor levelsLong-term safetyWorld Federation of HemophiliaHemophilia AViral vectorsOptimal treatmentEfficacy dataClinical phenotypeCoagulation factorsTherapy productsHemophiliaTherapyTransgene expressionAmerican ThrombosisOutcome measuresFactor levels
2013
Changes in serum BDNF levels associated with moderate-intensity exercise in healthy young Japanese men
Goda A, Ohgi S, Kinpara K, Shigemori K, Fukuda K, Schneider E. Changes in serum BDNF levels associated with moderate-intensity exercise in healthy young Japanese men. SpringerPlus 2013, 2: 678. PMID: 24386624, PMCID: PMC3872285, DOI: 10.1186/2193-1801-2-678.Peer-Reviewed Original ResearchModerate-intensity exerciseAcute moderate-intensity exerciseSerum BDNF levelsSerum BDNFHealthy young Japanese menJapanese menBDNF levelsYoung Japanese menSerum brain-derived neurotrophic factor (BDNF) levelsBrain-derived neurotrophic factor levelsNeurotrophic factor levelsMale Japanese subjectsMinutes of exerciseJapanese male subjectsHuman-based studiesAcute exerciseNeurotrophic factorBDNFNeuronal transmissionMale subjectsPurposeThe purposeFactor levelsStationary bicycleJapanese subjectsYoung adults
2008
Follicular-fluid neurotrophin levels in women undergoing assisted reproductive technology for different etiologies of infertility
Buyuk E, Seifer DB. Follicular-fluid neurotrophin levels in women undergoing assisted reproductive technology for different etiologies of infertility. Fertility And Sterility 2008, 90: 1611-1615. PMID: 18222435, DOI: 10.1016/j.fertnstert.2007.08.085.Peer-Reviewed Original ResearchConceptsMale factor infertilityDifferent etiologiesOvarian reserveNerve growth factorBDNF levelsNeurotrophin levelsBrain-derived neurotrophic factor levelsNT-3 concentrationNeurotrophic factor levelsProspective observational studyDiminished ovarian reserveHistory of endometriosisPolycystic ovarian syndromeIVF cyclesOvarian syndromeNGF levelsFollicular fluidNeurotrophin concentrationsObservational studyMAIN OUTCOMENGF concentrationsInfertilityFactor levelsEndometriosisEtiology
2007
Follicular fluid brain derived neurotrophic factor (BDNF) levels in women undergoing ART for different etiologies of infertility
Buyuk E, Seifer D. Follicular fluid brain derived neurotrophic factor (BDNF) levels in women undergoing ART for different etiologies of infertility. Fertility And Sterility 2007, 88: s167. DOI: 10.1016/j.fertnstert.2007.07.580.Peer-Reviewed Original Research
2006
Antibody therapy for early-stage breast cancer: trastuzumab adjuvant and neoadjuvant trials
Mehra R, Burtness B. Antibody therapy for early-stage breast cancer: trastuzumab adjuvant and neoadjuvant trials. Expert Opinion On Biological Therapy 2006, 6: 951-962. PMID: 16918262, DOI: 10.1517/14712598.6.9.951.Peer-Reviewed Original ResearchConceptsBreast cancerVascular endothelial growth factor levelsEarly-stage breast cancerYear of trastuzumabHER2/neu geneGrowth factor levelsBreast cancer cellsAdjuvant settingNeoadjuvant trialsOverall survivalRandomised trialsAggressive courseImproved outcomesImmune responseTrastuzumabActivation initiatesFactor levelsHER2 phosphorylationMonoclonal antibodiesNeu geneCancerCancer cellsHER2TrialsAntibodies
1997
Temporal variability of jun family transcription factor levels in peripherally or centrally transected adult rat dorsal root ganglia
Kenney A, Kocsis J. Temporal variability of jun family transcription factor levels in peripherally or centrally transected adult rat dorsal root ganglia. Brain Research 1997, 52: 53-61. PMID: 9450677, DOI: 10.1016/s0169-328x(97)00211-8.Peer-Reviewed Original ResearchConceptsDorsal root gangliaDorsal root transectionPeripheral axotomyDRG neuronsRoot transectionRoot gangliaProtein levelsAdult rat lumbar dorsal root gangliaRat lumbar dorsal root gangliaLumbar dorsal root gangliaAdult rat dorsal root gangliaRat dorsal root gangliaNeurotrophic factor administrationSpinal nerve transectionC-Jun protein levelsAdministration of NGFFactor protein levelsJunD protein levelsTarget disconnectionNerve transectionFactor administrationPeripheral branchesTransectionFactor levelsRapid elevation
1995
Minocycline in rheumatoid arthritis. A 48-week, double-blind, placebo-controlled trial. MIRA Trial Group.
Tilley B, Alarcon G, Heyse S, Trentham D, Neuner R, Kaplan† D, Clegg D, Leisen J, Buckley L, Cooper S, Duncan H, Pillemer S, Tuttleman M, Fowler S. Minocycline in rheumatoid arthritis. A 48-week, double-blind, placebo-controlled trial. MIRA Trial Group. Annals Of Internal Medicine 1995, 122: 81-9. PMID: 7993000, DOI: 10.7326/0003-4819-122-2-199501150-00001.Peer-Reviewed Original ResearchConceptsIgM rheumatoid factor levelsErythrocyte sedimentation rateRheumatoid factor levelsRheumatoid arthritisMinocycline groupGlobal assessmentPlacebo groupMore patientsPlatelet countModified Health Assessment QuestionnaireFactor levelsEfficacy of minocyclineEvaluator's global assessmentWeek 48 visitActive rheumatoid arthritisHealth Assessment QuestionnairePatient global assessmentPlacebo-controlled trialModerate rheumatoid arthritisDisease-modifying drugsMechanism of actionJoint tendernessMorning stiffnessStudy medicationDisease activity
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