2022
SARS-CoV-2 is associated with changes in brain structure in UK Biobank
Douaud G, Lee S, Alfaro-Almagro F, Arthofer C, Wang C, McCarthy P, Lange F, Andersson J, Griffanti L, Duff E, Jbabdi S, Taschler B, Keating P, Winkler A, Collins R, Matthews P, Allen N, Miller K, Nichols T, Smith S. SARS-CoV-2 is associated with changes in brain structure in UK Biobank. Nature 2022, 604: 697-707. PMID: 35255491, PMCID: PMC9046077, DOI: 10.1038/s41586-022-04569-5.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Pre-existing risk factorsSARS-CoV-2 infectionSARS-CoV-2 casesPrimary olfactory cortexGreater reductionUK BiobankGreater cognitive declineMagnetic resonance imagingGray matter thicknessLongitudinal effectsNeuroinflammatory eventsRisk factorsOlfactory cortexMild casesBrain changesBrain pathologyCOVID-191Parahippocampal gyrusBrain imaging resultsCognitive declineTissue damageResonance imagingOlfactory pathwayOrbitofrontal cortex
2020
Exploring the molecular approach of COX and LOX in Alzheimer’s and Parkinson’s disorder
Kumar A, Behl T, Jamwal S, Kaur I, Sood A, Kumar P. Exploring the molecular approach of COX and LOX in Alzheimer’s and Parkinson’s disorder. Molecular Biology Reports 2020, 47: 9895-9912. PMID: 33263931, DOI: 10.1007/s11033-020-06033-x.Peer-Reviewed Original ResearchConceptsParkinson's diseaseDocosahexaenoic acidAlzheimer's diseaseArachidonic acidLipid mediatorsAnti-inflammatory actionAppropriate therapeutic optionPro-inflammatory eicosanoidsProduction of eicosanoidsResolution of inflammationRole of AACOX-2 enzymeLOX pathwayNeuroinflammatory responseNeuroinflammatory eventsTherapeutic optionsAD patientsCytokine secretionEpidemiological studiesLeukocyte traffickingNF-κBEicosanoid productionBrain disordersNeurological disordersCyclooxygenase
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply