2001
COMBINATION THERAPY THAT TARGETS SECONDARY PULMONARY CHANGES AFTER ABDOMINAL TRAUMA
Davis K, Fabian T, Ragsdale D, Trenthem L, Croce M, Proctor K. COMBINATION THERAPY THAT TARGETS SECONDARY PULMONARY CHANGES AFTER ABDOMINAL TRAUMA. Shock 2001, 15: 479-484. PMID: 11386622, DOI: 10.1097/00024382-200115060-00012.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal AbscessAbdominal InjuriesAminoimidazole CarboxamideAnimalsAnti-Inflammatory AgentsBlood PressureCapillariesDisease Models, AnimalHemodynamicsInflammationLactatesLungLung InjuryNeutrophilsPulmonary AlveoliPulmonary ArteryResuscitationRibonucleotidesShock, HemorrhagicSteroidsSwineConceptsSecondary lung injuryAbdominal traumaG-CSFPMN activationLung injuryHemorrhagic shockAnalysis of BALLate septic complicationsLavage leukocyte countPulmonary reperfusion injurySecondary pulmonary changesAnti-inflammatory drugsAnti-inflammatory metabolitesWhite blood cellsNeutrophil sequestrationPulmonary contusionSeptic complicationsPMN infiltrationPulmonary changesReperfusion injurySecondary injuryResuscitation strategiesShed bloodCombination therapyEndogenous adenosine
2000
Endogenous Adenosine and Secondary Injury after Chest Trauma
Davis K, Fabian T, Ragsdale D, Trenthem L, Proctor A. Endogenous Adenosine and Secondary Injury after Chest Trauma. Journal Of Trauma And Acute Care Surgery 2000, 49: 892-898. PMID: 11086782, DOI: 10.1097/00005373-200011000-00017.Peer-Reviewed Original ResearchConceptsBlunt chest traumaBlunt chest injuryChest traumaAdenosine-regulating agentSecondary injuryBAL proteinChest injuriesEndogenous adenosineLung myeloperoxidase levelsTime of resuscitationAnti-inflammatory actionProgressive inflammatory responseAction of adenosineAlveolar-capillary membraneWet-dry ratioBAL WBCPulmonary contusionContralateral lungMyeloperoxidase levelsSystemic hemodynamicsUninjured lungsLung edemaRight chestMongrel pigsPathophysiologic changes
1993
Caffeine attenuates the renal vascular response to angiotensin II infusion.
Brown NJ, Ryder D, Nadeau J. Caffeine attenuates the renal vascular response to angiotensin II infusion. Hypertension 1993, 22: 847-852. PMID: 8244516, DOI: 10.1161/01.hyp.22.6.847.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal GlandsAldosteroneAnalysis of VarianceAngiotensin IIBlood PressureCaffeineCreatinineDose-Response Relationship, DrugDrug AntagonismHumansInfusions, IntravenousMetabolic Clearance Ratep-Aminohippuric AcidPotassiumRenal CirculationReninSingle-Blind MethodSodiumSodium Chloride, DietaryConceptsRenal plasma flowRenal plasma flow responsePara-aminohippurate clearancePlasma renin activityAngiotensin II infusionAng IIII infusionPlasma flow responseRenin activityBlood pressureEndogenous adenosineShort-term angiotensin II infusionBaseline plasma renin activityBaseline renal plasma flowTissue Ang II levelsAdenosine receptor antagonist caffeineRenal vascular responseRenal vasoconstrictive responseAng II levelsAng II infusionBaseline blood pressureBlood pressure responsePlacebo-controlled studyLong-term administrationTissue adenosine levels
1990
Caffeine potentiates the renin response to diazoxide in man. Evidence for a regulatory role of endogenous adenosine.
Brown NJ, Porter J, Ryder D, Branch RA. Caffeine potentiates the renin response to diazoxide in man. Evidence for a regulatory role of endogenous adenosine. Journal Of Pharmacology And Experimental Therapeutics 1990, 256: 56-61. PMID: 1988669, DOI: 10.1016/s0022-3565(25)23205-0.Peer-Reviewed Original ResearchConceptsRenin responseEndogenous adenosineRenin releaseDiazoxide infusionAdenosine inhibitsRegulation of reninCross-over studyAdministration of diazoxideAdenosine receptor blockerModest tachycardiaPRA responseReceptor blockersBP responseLoading dosePRA measurementsContinuous infusionNormal subjectsStudy daysDiazoxideMaximal pulseInfusionPresence of caffeineReninCaffeineAdenosine
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