2022
Acute Hepatitis of Unknown Origin in Children: Early Observations from the 2022 Outbreak
Zhang LY, Huang LS, Yue YH, Fawaz R, Lim JK, Fan JG. Acute Hepatitis of Unknown Origin in Children: Early Observations from the 2022 Outbreak. Journal Of Clinical And Translational Hepatology 2022, 10: 522-530. PMID: 35836761, PMCID: PMC9240245, DOI: 10.14218/jcth.2022.00281.Peer-Reviewed Original ResearchAcute hepatitisSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Unknown originRespiratory syndrome coronavirus 2Serum aminotransaminase levelsAcute liver failureIU/LSyndrome coronavirus 2Immune cell activationAminotransaminase levelsGastrointestinal symptomsLiver transplantationLiver failureCoronavirus 2Healthy childrenNegative testCell activationHepatitisCOVID-19 pandemicChildrenRecent reportsEarlier observationsOutbreakCause
2018
The Medalist Trial: Results of a Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Luspatercept to Treat Anemia in Patients with Very Low-, Low-, or Intermediate-Risk Myelodysplastic Syndromes (MDS) with Ring Sideroblasts (RS) Who Require Red Blood Cell (RBC) Transfusions
Fenaux P, Platzbecker U, Mufti G, Garcia-Manero G, Buckstein R, Santini V, Díez-Campelo M, Finelli C, Cazzola M, Ilhan O, Sekeres M, Falantes J, Arrizabalaga B, Salvi F, Giai V, Vyas P, Bowen D, Selleslag D, DeZern A, Jurcic J, Germing U, Götze K, Quesnel B, Beyne-Rauzy O, Cluzeau T, Voso M, Mazure D, Vellenga E, Greenberg P, Hellström-Lindberg E, Zeidan A, Laadem A, Benzohra A, Zhang J, Rampersad A, Linde P, Sherman M, Komrokji R, List A. The Medalist Trial: Results of a Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Luspatercept to Treat Anemia in Patients with Very Low-, Low-, or Intermediate-Risk Myelodysplastic Syndromes (MDS) with Ring Sideroblasts (RS) Who Require Red Blood Cell (RBC) Transfusions. Blood 2018, 132: 1. DOI: 10.1182/blood-2018-99-110805.Peer-Reviewed Original ResearchIntermediate-risk myelodysplastic syndromesErythropoiesis-stimulating agentsIU/LKey secondary endpointMyelodysplastic syndromeRBC-TIRBC transfusionRing sideroblastsSpeakers bureauSecondary endpointsPrimary endpointWeek 1Class erythroid maturation agentRed blood cell transfusionInternational Prognostic Scoring SystemLower-risk myelodysplastic syndromesAdvisory CommitteeAbsence of transfusionIWG 2006 criteriaMean hemoglobin increaseRBC transfusion dependenceRBC transfusion independencePatient baseline characteristicsPlacebo-controlled studyBlood cell transfusion
2015
Blood type predicts live birth in the infertile population
Goldsammler M, Jindal SK, Kallen A, Mmbaga N, Pal L. Blood type predicts live birth in the infertile population. Journal Of Assisted Reproduction And Genetics 2015, 32: 551-555. PMID: 25701141, PMCID: PMC4380903, DOI: 10.1007/s10815-015-0441-2.Peer-Reviewed Original ResearchConceptsIVF cycle outcomesIU/LLive birthsBlood type ABlood type BBlood typeBaseline FSHInfertile womenCycle outcomeMultivariable logistic regression analysisIVF cycle parametersBlood type OPatient's blood typeType BLogistic regression analysisType AType OOvulatory infertilityPatient characteristicsIVF outcomesMethodsRetrospective studyInfertile populationHigher oddsAcademic centersInfertility
2012
Elevated alanine aminotransferase in antiretroviral‐naïve HIV‐infected African patients: magnitude and risk factors
Nagu T, Kanyangarara M, Hawkins C, Hertmark E, Chalamila G, Spiegelman D, Mugusi F, Fawzi W. Elevated alanine aminotransferase in antiretroviral‐naïve HIV‐infected African patients: magnitude and risk factors. HIV Medicine 2012, 13: 541-548. PMID: 22416813, PMCID: PMC3391335, DOI: 10.1111/j.1468-1293.2012.01006.x.Peer-Reviewed Original ResearchConceptsElevated alanine aminotransferaseIU/LAlanine aminotransferaseAntiretroviral therapyHigh riskWorld Health Organization clinical stageCD4 T-lymphocyte countFirst-line antiretroviral therapyHepatitis B virus coinfectionALT measurementsLow-density lipoprotein cholesterolLog-binomial regression modelsB virus coinfectionT-lymphocyte countsART-naïve HIVCells/μLHepatotoxic side effectsCurrent tuberculosis (TB) treatmentResource-limited settingsCross-sectional analysisAdvanced immunosuppressionHBV coinfectionART-naïveHIV careLipoprotein cholesterol
2009
Utility of Hepatic Transaminases to Recognize Abuse in Children
Lindberg D, Makoroff K, Harper N, Laskey A, Bechtel K, Deye K, Shapiro R. Utility of Hepatic Transaminases to Recognize Abuse in Children. 2009, 124: 509-516. PMID: 19620197, DOI: 10.1542/peds.2008-2348.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal InjuriesAlanine TransaminaseAspartate AminotransferasesChild AbuseChild, PreschoolEmergency Service, HospitalFemaleHumansInfantInfant, NewbornLiver Function TestsMagnetic Resonance ImagingMaleMass ScreeningPhysical ExaminationPredictive Value of TestsProspective StudiesReference ValuesReferral and ConsultationROC CurveTomography, X-Ray ComputedConceptsIU/LAbdominal injuriesAbdominal bruisingHepatic transaminasesPhysical abuseElevated transaminase levelsClinical examination findingsStandard of careChild abuse teamPopulation of childrenPossible physical abuseSubspecialty evaluationALT levelsTransaminase levelsClinical findingsExamination findingsObservational studyRoutine screeningAbdominal imagingImportant causeInjuryUniversal imagingTransaminaseChild physical abusePatientsBlunt Abdominal Trauma in Children: A Score to Predict the Absence of Organ Injury
Karam O, Sanchez O, Chardot C, La Scala G. Blunt Abdominal Trauma in Children: A Score to Predict the Absence of Organ Injury. The Journal Of Pediatrics 2009, 154: 912-917. PMID: 19230903, DOI: 10.1016/j.jpeds.2009.01.001.Peer-Reviewed Original ResearchConceptsBlunt abdominal traumaIU/LNegative predictive valueAbdominal Doppler ultrasoundAbdominal traumaOrgan injuryDoppler ultrasoundIntra-abdominal organ injuryWhite blood cell countGood negative predictive valueIntra-abdominal injuriesTertiary care hospitalIntra-abdominal lesionsBlood cell countSystematic CT scanAbdominal painPeritoneal irritationHemodynamic instabilityInitial workupCare hospitalConsecutive patientsHospital admissionStable patientsAlanine aminotransferaseCT scan
2005
Intermittent Cardiac Troponin-I Screening is an Effective Means of Surveillance for a Perioperative Myocardial Infarction
Martinez EA, Nass CM, Jermyn RM, Rosenbaum SH, Akhtar S, Chan DW, Malkus H, Weiss JL, Fleisher LA. Intermittent Cardiac Troponin-I Screening is an Effective Means of Surveillance for a Perioperative Myocardial Infarction. Journal Of Cardiothoracic And Vascular Anesthesia 2005, 19: 577-582. PMID: 16202889, DOI: 10.1053/j.jvca.2005.07.002.Peer-Reviewed Original ResearchConceptsHigh diagnostic yieldPositive predictive valueDiagnosis of MIPostoperative day 1Myocardial infarctionDiagnostic yieldCardiac troponinNoncardiac surgeryCardiac injuryCreatine kinaseDay 1Surveillance strategiesIncidence of MIPerioperative cardiac injuryHigh-risk patientsPerioperative myocardial infarctionSubset of patientsIU/LGreater positive predictive valueTotal creatine kinaseCK-MB massCardiac protein markersPerioperative incidencePerioperative surveillanceCohort study
1998
Impact of Varying Stages of Endometriosis on the Outcome of In Vitro Fertilization–Embryo Transfer
Pal L, Shifren J, Isaacson K, Chang Y, Leykin L, Toth T. Impact of Varying Stages of Endometriosis on the Outcome of In Vitro Fertilization–Embryo Transfer. Journal Of Assisted Reproduction And Genetics 1998, 15: 27-31. PMID: 9493063, PMCID: PMC3468198, DOI: 10.1023/a:1022574221115.Peer-Reviewed Original ResearchConceptsSeverity of endometriosisMale factor infertilityIVF cyclesIVF-ETGroup BGroup AIVF-embryo transfer cyclesVitro Fertilization-Embryo TransferAmerican Fertility Society classificationGonadotropin-releasing hormone agonistAcademic IVF programDay 3 follicleHuman menopausal gonadotropinCycles of IVFFertilization-embryo transferIU/LCombination of FSHOocytes of patientsSeverity of diseaseQuality of oocytesImpact of severityMenopausal gonadotropinOvarian hyperstimulationAdvanced diseaseClinical pregnancy
1993
Proliferative index of human luteinized granulosa cells varies as a function of ovarian reserve
Seifer D, Charland C, Berlinsky D, Penzias A, Haning R, Naftolin F, Barker B. Proliferative index of human luteinized granulosa cells varies as a function of ovarian reserve. American Journal Of Obstetrics And Gynecology 1993, 169: 1531-1535. PMID: 8267057, DOI: 10.1016/0002-9378(93)90430-q.Peer-Reviewed Original ResearchConceptsSerum follicle-stimulating hormone levelsFollicle-stimulating hormone levelsFollicle-stimulating hormoneLuteinized granulosa cellsIU/L.Ovarian reserveHormone levelsProliferative indexGranulosa cellsHormone groupChronologic agePreovulatory folliclesDay 3 follicle-stimulating hormone levelsHigh follicle-stimulating hormoneLower follicle-stimulating hormoneSerum follicle-stimulating hormoneFlow cytometryHuman luteinized granulosa cellsGreater proliferative indexSame chronologic ageWoman's ovarian reserveOvulation induction protocolsProspective cohort studyAdvanced reproductive ageIU/L
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply