2023
Prevalence of HIV-1 infection and associated characteristics in a Brazilian indigenous population: a cross-sectional study
Schnaufer E, Barbosa M, Marques M, Brito G, Ferreira T, Ribeiro A, Valiente A, Machado I, Gonçalves C, Tanaka T, Guimarães M, Ribeiro S, Croda J, Simionatto S. Prevalence of HIV-1 infection and associated characteristics in a Brazilian indigenous population: a cross-sectional study. The Lancet Regional Health - Americas 2023, 25: 100562. PMID: 37559945, PMCID: PMC10407292, DOI: 10.1016/j.lana.2023.100562.Peer-Reviewed Original ResearchDrug resistance mutationsHIV-1 infectionReverse transcriptase inhibitorCross-sectional studyViral loadHIV infectionTranscriptase inhibitorHIV-1HIV-1 drug resistance mutationsHIV-1 viral loadNon-nucleoside reverse transcriptase inhibitorNucleoside reverse transcriptase inhibitorHIV-1 subtype CT-lymphocyte countsVulnerable populationsWeeks of treatmentCopies/mLHigh viral loadHealth promotion strategiesTime of recruitmentOngoing molecular surveillanceAreas of preventionAntiretroviral therapyHIV seroprevalenceLymphocyte count
2022
Impact of prerelease methadone on mortality among people with HIV and opioid use disorder after prison release: results from a randomized and participant choice open-label trial in Malaysia
Bazazi A, Culbert G, Wegman M, Heimer R, Kamarulzaman A, Altice F. Impact of prerelease methadone on mortality among people with HIV and opioid use disorder after prison release: results from a randomized and participant choice open-label trial in Malaysia. BMC Infectious Diseases 2022, 22: 837. PMID: 36368939, PMCID: PMC9652918, DOI: 10.1186/s12879-022-07804-6.Peer-Reviewed Original ResearchConceptsOpioid use disorderOpioid agonist therapyInfectious etiologyMost deathsUse disordersSample of menPrison releaseOpen-label trialT-lymphocyte countsPredictors of mortalityNational death recordsCrude mortality rateProportional hazards modelCovariate-adjusted modelsLow CD4Methadone initiationModified intentionAgonist therapySurvival benefitTreat analysisMethodsThis studyHIVHazards modelMortality rateMethadone
2018
Safety of lumbar puncture procedure in an international research setting during acute HIV infection
Chan P, Hellmuth J, Colby D, Kroon E, Sacdalan C, Fletcher J, Patel P, Pinyakorn S, Valcour V, Ananworanich J, Spudich S. Safety of lumbar puncture procedure in an international research setting during acute HIV infection. Journal Of Virus Eradication 2018, 4: 16-20. PMID: 29568548, PMCID: PMC5851179, DOI: 10.1016/s2055-6640(20)30236-3.Peer-Reviewed Original ResearchPost-lumbar puncture headacheAcute HIV infectionCombination antiretroviral therapyBody mass indexLumbar punctureHIV infectionAtraumatic needlesCerebrospinal fluidCSF HIV viral loadHigher Body Mass IndexT-lymphocyte countsAcute retroviral syndromeHIV viral loadFrequency of PPHCerebrospinal fluid volumeLumbar puncture procedureCART initiationAntiretroviral therapyLymphocyte countMass indexViral loadPuncture headacheClinical recordsLongitudinal visitsSubgroup analysis
2015
Practical Management of HIV-Associated Anemia in Resource-Limited Settings: Prospective Observational Evaluation of a New Mozambican Guideline
Brentlinger PE, Silva WP, Vermund SH, Valverde E, Buene M, Moon TD. Practical Management of HIV-Associated Anemia in Resource-Limited Settings: Prospective Observational Evaluation of a New Mozambican Guideline. AIDS Research And Human Retroviruses 2015, 32: 12-25. PMID: 26178574, PMCID: PMC4692124, DOI: 10.1089/aid.2015.0030.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnemiaAnthelminticsAnti-HIV AgentsAntimalarialsAntitubercular AgentsCD4 Lymphocyte CountCoinfectionDeveloping CountriesDisease ManagementFemaleHelminthiasisHemoglobinsHIV InfectionsHumansLost to Follow-UpMalaria, FalciparumMaleMozambiquePractice Guidelines as TopicProspective StudiesRural PopulationTuberculosis, PulmonaryConceptsHIV-associated anemiaAdverse drug reactionsDrug reactionsHemoglobin responseGuideline revisionsIron deficiencyLower body mass indexCo-trimoxazole prophylaxisDiscontinuation of zidovudineLaboratory-confirmed malariaProspective observational evaluationRural Zambézia ProvinceT-cell countsT-lymphocyte countsSmear-positive tuberculosisBody mass indexResource limited settingsResource-limited settingsLogistic regression modelsAnaemic HIVStudy cliniciansAntiretroviral therapyEsophageal candidiasisPresumptive treatmentAnemia managementPredictors of trends were similar for absolute and percentage CD4+ T-lymphocytes in HIV-infected children in Ghana
Renner L, Ghebremichael M, Goka B, Lartey M, Kwara A, Paintsil E. Predictors of trends were similar for absolute and percentage CD4+ T-lymphocytes in HIV-infected children in Ghana. Journal Of Pediatric Infectious Diseases 2015, 6: 7-15. DOI: 10.3233/jpi-2011-0293.Peer-Reviewed Original ResearchPercentage CD4T lymphocytesResource-limited settingsAbsolute CD4Human immune deficiency virus (HIV) infectionWorld Health Organization (WHO) clinical stagingKorle-Bu Teaching HospitalPaediatric HIV cohortsPredictors of trendsT-lymphocyte countsHIV cohortPediatric HIVClinical stagingPatient referralTeaching hospitalRetrospective analysisVirus infectionCD4HIVPredictorsChildrenMixed modelsSubsequent valuesHospitalReferral
2014
Management of Fever in Ambulatory HIV-Infected Adults in Resource-Limited Settings
Brentlinger PE, Silva WP, Buene M, Morais L, Valverde E, Vermund SH, Moon TD. Management of Fever in Ambulatory HIV-Infected Adults in Resource-Limited Settings. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2014, 67: 304-309. PMID: 25314251, PMCID: PMC5844466, DOI: 10.1097/qai.0000000000000304.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS-Related Opportunistic InfectionsAmbulatory CareAnti-Bacterial AgentsAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveBacterial InfectionsCD4 Lymphocyte CountDisease ManagementFemaleFeverHIV InfectionsHumansMaleMultivariate AnalysisOutcome Assessment, Health CarePractice Guidelines as TopicProspective StudiesRisk FactorsViral LoadConceptsManagement of feverLow CD4 T-lymphocyte countCD4 T-lymphocyte countLower body mass indexBacterial blood stream infectionsSpecific alternative diagnosesT-lymphocyte countsHistory of feverProspective observational studyBlood stream infectionsBody mass indexResource limited settingsAmbulatory HIVAntiretroviral therapyMalaria testingLower hemoglobinMass indexAdverse outcomesAlternative diagnosesObservational studyAxillary temperatureGuideline performanceMultivariate analysisHIVFever
2013
Bacteremia as a Cause of Fever in Ambulatory, HIV-Infected Mozambican Adults: Results and Policy Implications from a Prospective Observational Study
Moon TD, Silva WP, Buene M, Morais L, Valverde E, Vermund SH, Brentlinger PE. Bacteremia as a Cause of Fever in Ambulatory, HIV-Infected Mozambican Adults: Results and Policy Implications from a Prospective Observational Study. PLOS ONE 2013, 8: e83591. PMID: 24386229, PMCID: PMC3875454, DOI: 10.1371/journal.pone.0083591.Peer-Reviewed Original ResearchConceptsProspective observational studyAmbulatory HIVFebrile patientsObservational studySusceptibility patternsLarge prospective observational studyT-lymphocyte countsSpecific antimicrobial therapyCause of feverCases of bacteremiaFirst-line antibioticsPeripheral health unitsAntimicrobial susceptibility patternsNon-physician cliniciansNon-typhoid SalmonellaResource-limited settingsBlood culture specimensLow CD4Presumptive antibioticsClinical characteristicsRecent feverClinical profileLower hemoglobinPrescribing practicesAntimicrobial therapy
2012
Elevated alanine aminotransferase in antiretroviral‐naïve HIV‐infected African patients: magnitude and risk factors
Nagu T, Kanyangarara M, Hawkins C, Hertmark E, Chalamila G, Spiegelman D, Mugusi F, Fawzi W. Elevated alanine aminotransferase in antiretroviral‐naïve HIV‐infected African patients: magnitude and risk factors. HIV Medicine 2012, 13: 541-548. PMID: 22416813, PMCID: PMC3391335, DOI: 10.1111/j.1468-1293.2012.01006.x.Peer-Reviewed Original ResearchConceptsElevated alanine aminotransferaseIU/LAlanine aminotransferaseAntiretroviral therapyHigh riskWorld Health Organization clinical stageCD4 T-lymphocyte countFirst-line antiretroviral therapyHepatitis B virus coinfectionALT measurementsLow-density lipoprotein cholesterolLog-binomial regression modelsB virus coinfectionT-lymphocyte countsART-naïve HIVCells/μLHepatotoxic side effectsCurrent tuberculosis (TB) treatmentResource-limited settingsCross-sectional analysisAdvanced immunosuppressionHBV coinfectionART-naïveHIV careLipoprotein cholesterol
2011
Time to and Predictors of CD4+ T‐Lymphocytes Recovery in HIV‐Infected Children Initiating Highly Active Antiretroviral Therapy in Ghana
Renner L, Prin M, Li FY, Goka B, Northrup V, Paintsil E. Time to and Predictors of CD4+ T‐Lymphocytes Recovery in HIV‐Infected Children Initiating Highly Active Antiretroviral Therapy in Ghana. AIDS Research And Treatment 2011, 2011: 896040. PMID: 21738861, PMCID: PMC3124224, DOI: 10.1155/2011/896040.Peer-Reviewed Original ResearchT-lymphocyte recoveryPredictors of CD4Resource-limited settingsHAART initiationKorle-Bu Teaching HospitalMost resource-limited settingsCox proportional hazards modelT-lymphocyte countsActive antiretroviral therapyMedian recovery timeProportional hazards modelPredictors of timeComplete CD4Percent CD4Antiretroviral therapyActive antiretroviralsMean ageTeaching hospitalT lymphocytesCD4Hazards modelHIVChildrenAgeSignificant predictor variables
2010
Late Presentation for Human Immunodeficiency Virus Care in the United States and Canada
Althoff KN, Gange SJ, Klein MB, Brooks JT, Hogg RS, Bosch RJ, Horberg MA, Saag MS, Kitahata MM, Justice AC, Gebo KA, Eron JJ, Rourke SB, Gill MJ, Rodriguez B, Sterling TR, Calzavara LM, Deeks SG, Martin JN, Rachlis AR, Napravnik S, Jacobson LP, Kirk GD, Collier AC, Benson CA, Silverberg MJ, Kushel M, Goedert JJ, McKaig RG, Van Rompaey SE, Zhang J, Moore RD, Research and Design N. Late Presentation for Human Immunodeficiency Virus Care in the United States and Canada. Clinical Infectious Diseases 2010, 50: 1512-1520. PMID: 20415573, PMCID: PMC2862849, DOI: 10.1086/652650.Peer-Reviewed Original ResearchConceptsMean CD4 countPercentage of patientsHIV transmission riskCD4 countHIV careFirst presentationTransmission riskCells/North American AIDS Cohort CollaborationHuman immunodeficiency virus (HIV) careHuman immunodeficiency virus (HIV) servicesHeterosexual transmission riskMedian CD4 countEarly HIV diagnosisT-lymphocyte countsHIV RNA measurementsHistory of AIDSRace/ethnicityAntiretroviral exposureCohort CollaborationHIV diagnosisLymphocyte countInitial presentationMedian ageLate presentation
2008
Failure of atorvastatin to modulate CSF HIV-1 infection
Probasco JC, Spudich SS, Critchfield J, Lee E, Lollo N, Deeks SG, Price RW. Failure of atorvastatin to modulate CSF HIV-1 infection. Neurology 2008, 71: 521-524. PMID: 18695163, PMCID: PMC2676982, DOI: 10.1212/01.wnl.0000325006.84658.e7.Peer-Reviewed Original ResearchConceptsHIV-1 infectionHIV-1 RNA levelsT-cell countsCell countIntrathecal immunoactivationNeopterin concentrationsBlood lipidsBlood HIV-1 RNA levelCSF HIV-1 RNA levelsCSF white blood cell countCNS HIV-1 infectionSystemic HIV-1 infectionSingle-arm pilot studyWhite blood cell countPilot studyAntiretroviral-naïve subjectsCells/mulRNA levelsUntreated systemic infectionT-lymphocyte countsSmall uncontrolled studiesEffect of atorvastatinHMG-CoA reductase inhibitorsWeeks of treatmentHIV-1 RNA
2007
Superiority of Directly Administered Antiretroviral Therapy over Self-Administered Therapy among HIV-Infected Drug Users: A Prospective, Randomized, Controlled Trial
Altice FL, Maru DS, Bruce RD, Springer SA, Friedland GH. Superiority of Directly Administered Antiretroviral Therapy over Self-Administered Therapy among HIV-Infected Drug Users: A Prospective, Randomized, Controlled Trial. Clinical Infectious Diseases 2007, 45: 770-778. PMID: 17712763, PMCID: PMC2693907, DOI: 10.1086/521166.Peer-Reviewed Original ResearchConceptsHIV-1 RNA levelsSelf-administered therapyT-lymphocyte countsDrug usersAntiretroviral therapyLymphocyte countRNA levelsPrimary outcomeProportion of patientsGreater mean reductionHIV treatment programsLog10 copies/Human immunodeficiency virusCopies/mLDAART groupVirologic outcomesSecondary outcomesControlled TrialsImmunodeficiency virusPoor adherenceTreatment adherenceEntry criteriaTreat approachCopies/Mean change
2001
Infections with Ehrlichia chaffeensis and Ehrlichia ewingii in Persons Coinfected with Human Immunodeficiency Virus
Paddock C, Folk S, Shore G, Machado L, Huycke M, Slater L, Liddell A, Buller R, Storch G, Monson T, Rimland D, Sumner J, Singleton J, Bloch K, Tang Y, Standaert S, Childs J. Infections with Ehrlichia chaffeensis and Ehrlichia ewingii in Persons Coinfected with Human Immunodeficiency Virus. Clinical Infectious Diseases 2001, 33: 1586-1594. PMID: 11568857, DOI: 10.1086/323981.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusImmunodeficiency virusE. ewingiiE. chaffeensisCases of ehrlichiosisDiagnosis of ehrlichiosisT-lymphocyte countsCells/microL.Ehrlichia ewingiiEhrlichia chaffeensisLife-threatening illnessLymphocyte countClinical courseHIV infectionMedical managementPatient cohortSevere manifestationsPatientsLaboratory evaluationEhrlichiosisChaffeensisInfectionEwingiiMultiple factorsVirusDo HIV Type 1 RNA Levels Provide Additional Prognostic Value to CD4+ T Lymphocyte Counts in Patients with Advanced HIV Type 1 Infection?
Arduino J, Fischl M, Stanley K, Collier A, Spiegelman D. Do HIV Type 1 RNA Levels Provide Additional Prognostic Value to CD4+ T Lymphocyte Counts in Patients with Advanced HIV Type 1 Infection? AIDS Research And Human Retroviruses 2001, 17: 1099-1105. PMID: 11522179, DOI: 10.1089/088922201316912709.Peer-Reviewed Original ResearchConceptsHIV-1 RNA levelsHIV-1 disease progressionBaseline HIV-1 RNA levelsT-lymphocyte countsT lymphocytesDisease progressionLymphocyte countRNA levelsCells/Prognostic informationHigh baseline HIV-1 RNA levelsHIV type 1 RNA levelsPlasma HIV-1 RNA levelsSubsequent HIV-1 disease progressionAdvanced HIV-1 diseaseHIV Type 1 InfectionConditional logistic regression analysisDisease progression independentHIV-1 diseaseAdditional prognostic informationAdditional prognostic valueType 1 infectionCase-control studyLogistic regression analysisClinical status
2000
Predictors of Change in the Functional Status of Children With Human Immunodeficiency Virus Infection
Missmer S, Spiegelman D, Gorbach S, Miller T. Predictors of Change in the Functional Status of Children With Human Immunodeficiency Virus Infection. 2000, 106: e24-e24. PMID: 10920180, DOI: 10.1542/peds.106.2.e24.Peer-Reviewed Original ResearchConceptsHeight z-scoreHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionTotal health scoreFunctional statusHealth scoresZ-scoreGeneral healthVirus infectionBaseline evaluationCD4 T-lymphocyte countFunctional status parametersFunctional status surveyHIV disease stageT-lymphocyte countsAbsolute CD4 countGeneral health scoresImportant clinical predictorsSignificant univariate predictorsFunctional status scoresMain outcome measuresNon-white raceResponsiveness scoresPredictors of changeCD4 count
1997
Helper T-lymphocyte count. TRAx CD4 test kit versus conventional flow cytometry.
Saah A, Spruill C, Hoover D, Prevots R, Taylor E, Margolick J, Vlahov D. Helper T-lymphocyte count. TRAx CD4 test kit versus conventional flow cytometry. Archives Of Pathology & Laboratory Medicine 1997, 121: 960-2. PMID: 9302928.Peer-Reviewed Original ResearchConceptsHelper T-lymphocyte countT-lymphocyte countsEnzyme-linked immunosorbentHelper T-cell countsT-cell countsFlow cytometryHuman immunodeficiency virus-infected injection drug usersTRAx CD4 Test KitHelper T cellsInjection drug usersCohort studyFlow cytometry resultsT cellsDrug usersImmunosorbentCytometry resultsCytometryTest kitConventional flow cytometryCountAcceptable methodFlow cytometry countsCytometry countsCellsReduction in the Risk of Vertical Transmission of HIV-1 Associated with Treatment of Pregnant Women with Orally Administered Zidovudine Alone
Simpson B, Shapiro E, Andiman W. Reduction in the Risk of Vertical Transmission of HIV-1 Associated with Treatment of Pregnant Women with Orally Administered Zidovudine Alone. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1997, 14: 145-152. PMID: 9052723, DOI: 10.1097/00042560-199702010-00007.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAdolescentAdultAnti-HIV AgentsCD4 Lymphocyte CountCohort StudiesDelivery, ObstetricFemaleHIV InfectionsHIV-1HumansInfantInfant, NewbornInfectious Disease Transmission, VerticalLongitudinal StudiesOdds RatioPregnancyPregnancy Complications, InfectiousProspective StudiesRetrospective StudiesRisk FactorsZidovudineConceptsRisk of transmissionT-lymphocyte countsMode of deliveryVertical transmissionHIV-1Cell countT-cell countsProspective cohort studyRisk of motherRoutine prenatal careSubgroup of womenChild transmissionUntreated womenCohort studyUntreated mothersPregnant womenPrenatal careObservational studyCD4ZidovudineSignificant associationWomenMothersRiskSignificant reduction
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