2010
Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients.
Rosenberg S, Elashoff MR, Beineke P, Daniels SE, Wingrove JA, Tingley WG, Sager PT, Sehnert AJ, Yau M, Kraus WE, Newby LK, Schwartz RS, Voros S, Ellis SG, Tahirkheli N, Waksman R, McPherson J, Lansky A, Winn ME, Schork NJ, Topol EJ. Multicenter validation of the diagnostic accuracy of a blood-based gene expression test for assessing obstructive coronary artery disease in nondiabetic patients. Annals Of Internal Medicine 2010, 153: 425-34. PMID: 20921541, PMCID: PMC3786733, DOI: 10.7326/0003-4819-153-7-201010050-00005.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overAlgorithmsArea Under CurveChest PainCoronary AngiographyCoronary Artery DiseaseDiabetes MellitusFemaleGene ExpressionHumansMaleMiddle AgedProspective StudiesReverse Transcriptase Polymerase Chain ReactionRisk AssessmentROC CurveSensitivity and SpecificitySex FactorsYoung AdultConceptsObstructive coronary artery diseaseCoronary artery diseaseCoronary angiographyNondiabetic patientsQuantitative coronary angiographyArtery diseasePresence of CADClinical modelMore major coronary arteriesPeripheral blood gene expressionBlood-based gene expression testDiamond-Forrester methodMulticenter prospective trialMajor coronary arteriesChronic inflammatory disordersIndependent validation cohortReceiver-operating characteristic analysisBlood gene expressionReal-time polymerase chain reactionWhole blood testCardiac protein markersGene expression testNoninvasive imaging methodProspective trialRisk patients
2005
Intermittent Cardiac Troponin-I Screening is an Effective Means of Surveillance for a Perioperative Myocardial Infarction
Martinez EA, Nass CM, Jermyn RM, Rosenbaum SH, Akhtar S, Chan DW, Malkus H, Weiss JL, Fleisher LA. Intermittent Cardiac Troponin-I Screening is an Effective Means of Surveillance for a Perioperative Myocardial Infarction. Journal Of Cardiothoracic And Vascular Anesthesia 2005, 19: 577-582. PMID: 16202889, DOI: 10.1053/j.jvca.2005.07.002.Peer-Reviewed Original ResearchConceptsHigh diagnostic yieldPositive predictive valueDiagnosis of MIPostoperative day 1Myocardial infarctionDiagnostic yieldCardiac troponinNoncardiac surgeryCardiac injuryCreatine kinaseDay 1Surveillance strategiesIncidence of MIPerioperative cardiac injuryHigh-risk patientsPerioperative myocardial infarctionSubset of patientsIU/LGreater positive predictive valueTotal creatine kinaseCK-MB massCardiac protein markersPerioperative incidencePerioperative surveillanceCohort study
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