2024
Aflibercept Biosimilar MYL-1701P vs Reference Aflibercept in Diabetic Macular Edema
Bressler S, Barve A, Ganapathi P, Beckmann K, Apte R, Marcus D, Baumane K, Agarwal S, Oleksy P, Reichstein D, Patel S, Ernest J, Dégi R, Gupta V, Kishino G, Kamei M, Loganathan S, Chaudhry N, Reichstein D, Tabassian A, Fine H, Sjaarda R, Marcus D, Barakat M, Dugel, P, Eichenbaum D, Dessouki A, Berger A, Angle B, Chang M, Patel S, Brown D, Thach A, Baker C, Gordon A, Mansour S, Fox G, Alfaro D, Davies J, Ghorayeb G, Stoller G, Johnson T, Nemcansky J, Rehak J, Studnicka J, Ernest J, Korda V, Veith M, Krzyzanek D, Kalvodova B, Stodulka P, Feltgen N, PD K, Grisanti S, Gamulescu M, Kellner U, Sekundo W, Dahlke C, Zeitz O, Baumane K, Laganovska G, Ozolina S, Vajas A, Seres A, Tsorbatzoglou A, Radnoti J, Kiss K, Gombos K, Degi R, Varsanyi B, Kerenyi A, Noge S, Muramatsu T, Kaga T, Oh H, Watanabe M, Oshima Y, Fujita H, Kishino G, Hanemoto T, Murata K, Kitaoka T, Saito I, Tanabe T, Ebihara N, Imaizumi H, Ishii K, Kamei M, Furuta M, Ojima A, Sawada O, Kawasaki T, Otake H, Doi N, Abe, K, Matsuda S, Kobayashi N, Yoshizumi Y, Budzinskaya M, Lebedev O, Eremina A, Zolotarev A, Izmaylov A, Samoylov A, Astakhov S, Astakhov Y, Shkvorchenko D, Narayanan R, Agarwal K, Rahul S, Natesh S, Gupta V, Panchal B, Kaza H, K M, Agrawal V, Elhence A, Behera U, Raj L, Mazumdar S, Kannan N, Yadav N, Vohra R, Aggarwal S, Sonawane A, Saravanan V, Chauhan R, Fluder E, Nawrocki J, Wylegala E, Zalewski D, Oleksy P, Borcz E. Aflibercept Biosimilar MYL-1701P vs Reference Aflibercept in Diabetic Macular Edema. JAMA Ophthalmology 2024, 142: 952-960. PMID: 39264599, PMCID: PMC11393752, DOI: 10.1001/jamaophthalmol.2024.3458.Peer-Reviewed Original ResearchBest-corrected visual acuityDiabetic macular edemaCentral subfield thicknessEarly Treatment Diabetic Retinopathy StudyAflibercept groupAntidrug antibodiesAdverse eventsWeek 8Aflibercept armMacular edemaIncidence of treatment-emergent adverse eventsPrimary outcomeBaseline BCVA letter scoreTreatment Diabetic Retinopathy StudyTreatment-emergent adverse eventsIncidence of adverse eventsConsecutive intravitreal injectionsDiabetic Retinopathy StudyRandomized clinical trialsType 2 diabetesStudy eyesSubfield thicknessDouble-MaskedIntravitreal injectionRetinopathy StudyAssociation of Mild Iodine Insufficiency during Pregnancy with Child Neurodevelopment in Patients with Subclinical Hypothyroidism or Hypothyroxinemia
Casey B, Mele L, Peaceman A, Varner M, Reddy U, Wapner R, Thorp J, Saade G, Tita A, Rouse D, Sibai B, Costantine M, Mercer B, Caritis S. Association of Mild Iodine Insufficiency during Pregnancy with Child Neurodevelopment in Patients with Subclinical Hypothyroidism or Hypothyroxinemia. American Journal Of Perinatology 2024, 41: e3326-e3332. PMID: 38228158, PMCID: PMC11153033, DOI: 10.1055/s-0043-1778037.Peer-Reviewed Original ResearchUrinary iodine concentrationSubclinical hypothyroidismSubclinical thyroid diseasePregnant patientsIodine statusIodine insufficiencyThyroid diseaseIodine concentrationMaternal urinary iodine concentrationPrimary outcomePlacebo-controlled treatment trialMaternal iodine statusMild iodine insufficiencyIntelligence quotientFull-scale intelligence quotientYears of ageDifferential Ability Scales-IISingleton gestationsDouble-MaskedIdentical placeboLevothyroxine replacementWeeks gestationMaternal urineThyroid screeningSerum thyrotropin
1999
Prophylaxis Against Early Adrenal Insufficiency to Prevent Chronic Lung Disease in Premature Infants
Watterberg K, Gerdes J, Gifford K, Lin H. Prophylaxis Against Early Adrenal Insufficiency to Prevent Chronic Lung Disease in Premature Infants. 1999, 104: 1258-1263. PMID: 10585975, DOI: 10.1542/peds.104.6.1258.Peer-Reviewed Original ResearchConceptsChronic lung diseaseLow-dose hydrocortisoneAdrenal insufficiencyWeeks postconceptionBirth weightBiochemical evidence of adrenal insufficiencyEarly treatmentLung diseaseEvidence of adrenal insufficiencyDevelopment of chronic lung diseaseLow birth weight infantsInfants exposed to chorioamnionitisPlacebo-controlled pilot studyPrevent chronic lung diseaseLikelihood of survivalBirth weight infantsLow birth weightHours of lifeWeeks of lifeHistologic chorioamnionitisPlacebo infantsDouble-MaskedWeight infantsEnteral intakePremature infants
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