Integrated molecular and clinical characterization of pulmonary large cell neuroendocrine carcinoma
Nassar A, Kim C, Adeyelu T, Bou Farhat E, Abushukair H, Rakaee M, Matteson K, Lau S, Takabe Y, Ocejo A, Ardeshir-Larijani F, Leal T, Ramalingam S, Alam S, Gray J, Hicks J, Kaldas D, Baena J, Berjaga M, Nana F, Grohe C, Leuders H, Citarella F, Cortellini A, Mingo E, Pancirer D, Das M, Ellis-Caleo T, Cheung J, Lin J, Watson A, Camidge D, Sridhar A, Parikh K, Crowley F, Marron T, Aggarwal V, Ahmed M, Sankar K, Kawtharany H, Zhang J, Owen D, Li M, Nagasaka M, Pinato D, Awosika N, Alhamad K, Puri S, Zaman U, Gupta D, Lau C, Khan H, Liauw J, Velazquez A, Brown T, Moliner L, Mosteiro M, Rocha P, Evans M, Vanderwalde A, Elliott A, Nieva J, Lopes G, Ma P, Borghaei H, Lee M, Young L, Aljumaily R, Mirza H, Kwiatkowski D, Herbst R, Flavell R, Naqash A, Chiang A. Integrated molecular and clinical characterization of pulmonary large cell neuroendocrine carcinoma. Nature Communications 2025, 16: 7717. PMID: 40830141, PMCID: PMC12365225, DOI: 10.1038/s41467-025-63091-0.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkers, TumorCarcinoma, Large CellCarcinoma, NeuroendocrineCarcinoma, Non-Small-Cell LungFemaleGene Expression Regulation, NeoplasticHumansIntracellular Signaling Peptides and ProteinsKelch-Like ECH-Associated Protein 1Lung NeoplasmsLymphocytes, Tumor-InfiltratingMaleMembrane ProteinsMiddle AgedMutationTrypsin Inhibitor, Kazal PancreaticConceptsLarge cell neuroendocrine carcinomaPulmonary large cell neuroendocrine carcinomaCell neuroendocrine carcinomaNeuroendocrine carcinomaClinical characterizationFGL-1DLL3-targeting therapiesTumor-infiltrating lymphocytesAggressive lung tumorsImmunogenomic profilingSCLC-likeOverall survivalLAG-3SPINK1 expressionLung tumorsTreatment regimensAdverse eventsLung cancerIndependent cohortCancer-likeSerial samplesMolecular heterogeneitySPINK1CarcinomaTranscriptional profiles
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