Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma
Yang J, Wang C, Fu D, Ho L, Galani K, Chen L, Gonzalez J, Fu J, Huang A, Frederick D, He L, Asnani M, Tacke R, Robitschek E, Yadav S, Deng W, Burke K, Sharova T, Sullivan R, Weiss S, Rai K, Liu D, Boland G, Kellis M. Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma. Nature Communications 2025, 16: 8151. PMID: 40890106, PMCID: PMC12402436, DOI: 10.1038/s41467-025-62878-5.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsProgression-free survivalDendritic cellsTumor microenvironmentAnti-PD-1 checkpoint blockadeTranscriptional hallmarksCD8 T-cell ratiosT-and B-cellsAnti-PD-1 therapyDendritic cell subtypesT cell ratioConventional dendritic cellsMigratory dendritic cellsMetastatic melanoma samplesCheckpoint blockadeCheckpoint inhibitorsMetastatic melanomaImmunotherapy responsePredictive biomarkersImmune infiltrationMalignant cellsB cellsImmunoregulatory moleculesIndependent cohortMelanoma samples
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