2024
Absence of BOLD adaptation in chronic fatigue syndrome revealed by task functional MRI
Schönberg L, Mohamed A, Yu Q, Kwiatek R, Del Fante P, Calhoun V, Shan Z. Absence of BOLD adaptation in chronic fatigue syndrome revealed by task functional MRI. Cerebrovascular And Brain Metabolism Reviews 2024, 45: 115-124. PMID: 39113421, PMCID: PMC11840696, DOI: 10.1177/0271678x241270528.Peer-Reviewed Original ResearchBlood oxygen level-dependentFunctional MRIME/CFS participantsHealthy controlsTask-based functional MRISymbol Digit Modalities TestFatigue syndromeRight postcentral gyrusTask functional MRIFMRI signal changesOxygen level-dependentMyalgic encephalomyelitis/chronic fatigue syndromeLeft primary motor cortexChronic fatigue syndromeTask blocksCognitive tasksPostcentral gyrusCognitive cortexBOLD adaptationNeurophysiological processesNeurophysiological mechanismsPrimary motor cortexLevel-dependentModal testingFatigue severity
2023
Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue symptoms in ME/CFS
Guo C, Che X, Briese T, Ranjan A, Allicock O, Yates R, Cheng A, March D, Hornig M, Komaroff A, Levine S, Bateman L, Vernon S, Klimas N, Montoya J, Peterson D, Lipkin W, Williams B. Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue symptoms in ME/CFS. Cell Host & Microbe 2023, 31: 288-304.e8. PMID: 36758522, PMCID: PMC10183837, DOI: 10.1016/j.chom.2023.01.004.Peer-Reviewed Original ResearchConceptsME/CFSFaecalibacterium prausnitziiMyalgic encephalomyelitis/chronic fatigue syndromeFecal short-chain fatty acidsChronic fatigue syndromeShort-chain fatty acidsGut microbiome diversityGut dysbiosisGastrointestinal disturbancesTherapeutic trialsFatigue severityFatigue syndromeOrthostatic intoleranceValidation cohortHealthy controlsCognitive dysfunctionFatigue symptomsGut microbiomeDiverse cohortButyrate producersHuman gutPossible targetsEubacterium rectaleCohortMulti-omics analysisSevere Fatigue and Persistent Symptoms at 3 Months Following Severe Acute Respiratory Syndrome Coronavirus 2 Infections During the Pre-Delta, Delta, and Omicron Time Periods: A Multicenter Prospective Cohort Study
Gottlieb M, Wang R, Yu H, Spatz E, Montoy J, Rodriguez R, Chang A, Elmore J, Hannikainen P, Hill M, Huebinger R, Idris A, Lin Z, Koo K, McDonald S, O’Laughlin K, Plumb I, Santangelo M, Saydah S, Willis M, Wisk L, Venkatesh A, Stephens K, Weinstein R, Weinstein R, Gottlieb M, Santangelo M, Koo K, Derden A, Gottlieb M, Gatling K, Guzman D, Yang G, Kaadan M, Hassaballa M, Jerger R, Ahmed Z, Choi M, Venkatesh A, Spatz E, Lin Z, Li S, Yu H, Mannan I, Yang Z, Venkatesh A, Spatz E, Ulrich A, Kinsman J, Dorney J, Pierce S, Puente X, Nichol G, Stephens K, Anderson J, Morse D, Adams K, Maat Z, Stober T, O'Laughlin K, Gentile N, Geyer R, Willis M, Ruiz L, Malone K, Park J, Rising K, Kean E, Kelly M, Schaeffer K, Hannikainen P, Shughart L, Shughart H, Renzi N, Amadio G, Grau D, Watts P, Cheng D, Miao J, Shutty C, Charlton A, Hill M, Site R, Chavez S, Kane A, Nikonowicz P, Idris A, McDonald S, Gallegos D, Martin R, Elmore J, Wisk L, L'Hommedieu M, Chandler C, Eguchi M, Roldan K, Moreno R, Rodriguez R, Wang R, Montoy J, Kemball R, Chan V, Chavez C, Wong A, Arreguin M, Plumb I, Hall A, Saydah S, Briggs-Hagen M. Severe Fatigue and Persistent Symptoms at 3 Months Following Severe Acute Respiratory Syndrome Coronavirus 2 Infections During the Pre-Delta, Delta, and Omicron Time Periods: A Multicenter Prospective Cohort Study. Clinical Infectious Diseases 2023, 76: 1930-1941. PMID: 36705268, PMCID: PMC10249989, DOI: 10.1093/cid/ciad045.Peer-Reviewed Original ResearchConceptsProspective cohort studyMulticenter prospective cohort studySevere fatigueSARS-CoV-2 testingCohort studyEstimate independent effectsProlonged symptomsCOVID positive cohortMultivariate logistic regressionVaccination statusCOVID-positiveNegative SARS-CoV-2 testBaseline healthFatigue severityLong-term symptomsSARS-CoV-2Fatigue symptomsCharacterize prevalenceLogistic regressionEffects of variantsSevere acute respiratory syndrome coronavirus 2 infectionAcute illnessAcute respiratory syndrome coronavirus 2 infectionPost-SARS-CoV-2 infectionMultivariate model
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