2025
Progesterone restores blood-brain barrier and memory after chronic cerebral hypoperfusion in male rats
Espadín M, Cervantes M, Coyoy-Salgado A, Espinosa-Garcia C, Gómez-González B, Moralí G. Progesterone restores blood-brain barrier and memory after chronic cerebral hypoperfusion in male rats. Brain Behavior And Immunity Integrative 2025, 11: 100132. DOI: 10.1016/j.bbii.2025.100132.Peer-Reviewed Original ResearchChronic cerebral hypoperfusionBlood-brain barrierTight junction proteinsSpatial learningMale ratsJunction proteinsCerebral hypoperfusionSprague-Dawley ratsBlood-brain barrier dysfunctionEffects of P4Inflammatory factor levelsAge-related alterationsBrain injury modelInjury modelInflammation factorsRatsHypoperfusionNeuroprotective effectsFactor levelsIntroduction AgingProgesteroneMemoryAlterationsBrainDaysProtective role of parenthood on age-related brain function in mid- to late-life
Orchard E, Chopra S, Ooi L, Chen P, An L, Jamadar S, Yeo B, Rutherford H, Holmes A. Protective role of parenthood on age-related brain function in mid- to late-life. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2411245122. PMID: 39999172, PMCID: PMC11892684, DOI: 10.1073/pnas.2411245122.Peer-Reviewed Original ResearchConceptsBrain functionFunctional connectivityPatterns of brain functionAssociated with higher connectivityConsistent with animal modelsBrain structuresCaregiving environmentAssociated with patternsAge-related alterationsBrain healthAging trajectoriesLate-lifeSpatial topographyAdult brainImpact of caregivingBrainPreliminary findingsHuman parentingImpact of ageCaregiving experienceChildrenCaregiversHigher connectivityEffect of parenthoodOne-body
2017
The Effect of Dietary Glycemic Properties on Markers of Inflammation, Insulin Resistance, and Body Composition in Postmenopausal American Women: An Ancillary Study from a Multicenter Protein Supplementation Trial
Stojkovic V, Simpson CA, Sullivan RR, Cusano AM, Kerstetter JE, Kenny AM, Insogna KL, Bihuniak JD. The Effect of Dietary Glycemic Properties on Markers of Inflammation, Insulin Resistance, and Body Composition in Postmenopausal American Women: An Ancillary Study from a Multicenter Protein Supplementation Trial. Nutrients 2017, 9: 484. PMID: 28492492, PMCID: PMC5452214, DOI: 10.3390/nu9050484.Peer-Reviewed Original ResearchConceptsMarkers of inflammationInsulin resistanceGI/GLBody compositionAncillary studiesLean massPRO groupSignificant associationGlycemic load dietDouble-blind trialFat mass ratioTotal lean massTotal fat massPostmenopausal American womenTrunk lean massAge-related alterationsWhey protein supplementLoad dietInflammatory markersSerum CRPChronic inflammationIL-6Fat massSupplementation trialBone density
2016
Age-related alterations in immune responses to West Nile virus infection
Montgomery R. Age-related alterations in immune responses to West Nile virus infection. Clinical & Experimental Immunology 2016, 187: 26-34. PMID: 27612657, PMCID: PMC5167051, DOI: 10.1111/cei.12863.Peer-Reviewed Original ResearchConceptsWest Nile virusToll-like receptorsDendritic cellsSevere diseaseBlood-brain barrier permeabilityImportant public health concernWest Nile virus infectionHuman dendritic cellsNatural killer cellsAnti-viral responseMonocytes/macrophagesPathogen recognition receptorsAge-related alterationsSpecific immune parametersPublic health concernImportant causative agentAge-related impairmentIndividual host factorsAge-related changesKiller cellsViral encephalitisImmune cellsRisk factorsBarrier permeabilityHigh prevalenceRole of Immune Aging in Susceptibility to West Nile Virus
Yao Y, Montgomery RR. Role of Immune Aging in Susceptibility to West Nile Virus. Methods In Molecular Biology 2016, 1435: 235-247. PMID: 27188562, PMCID: PMC4941816, DOI: 10.1007/978-1-4939-3670-0_18.Peer-Reviewed Original ResearchConceptsWest Nile virusImmune dysregulationWNV infectionSevere neuroinvasive diseaseInnate immune cellsΓδ T cellsNile virusProminent risk factorAge-dependent dysregulationAge-related alterationsDendritic cellsNK cellsImmune agingNeuroinvasive diseaseImmune cellsRisk factorsT cellsImmune responseSpecific treatmentTherapeutic interventionsOlder peopleInfectionMass cytometryHost susceptibilityDysregulation
2015
Transforming Growth Factor &bgr;1 and Extracellular Matrix Protease Expression in the Uterosacral Ligaments of Patients With and Without Pelvic Organ Prolapse
Leegant A, Zuckerwise LC, Downing K, Brouwer-Visser J, Zhu C, Cossio MJ, Strube F, Xie X, Banks E, Huang GS. Transforming Growth Factor &bgr;1 and Extracellular Matrix Protease Expression in the Uterosacral Ligaments of Patients With and Without Pelvic Organ Prolapse. Urogynecology 2015, 21: 53-58. PMID: 25185601, PMCID: PMC4344824, DOI: 10.1097/spv.0000000000000130.Peer-Reviewed Original ResearchConceptsPelvic organ prolapseTGF-β1 expressionMMP-9 expressionTGF-β1Uterosacral ligamentsMMP-9Vaginal hysterectomyOrgan prolapseSmooth muscleFibrous tissueGreater pelvic organ prolapseGrowth factor-β1 expressionInstitutional review board approvalMatrix metalloproteinase-9Review board approvalAge-related alterationsGrowth factor-β1Benign indicationsMetalloproteinase-9Clinical dataImmunohistochemical stainingBoard approvalTrichrome stainingFactor-β1Β1 expression
2010
Age-induced disruption of selective olfactory bulb synaptic circuits
Richard MB, Taylor SR, Greer CA. Age-induced disruption of selective olfactory bulb synaptic circuits. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 15613-15618. PMID: 20679234, PMCID: PMC2932573, DOI: 10.1073/pnas.1007931107.Peer-Reviewed Original ResearchConceptsMouse OBLayer-specific alterationsAfferent synaptic inputExternal plexiform layerPrimary sensory cortexAge-related alterationsAge-related cognitive deficitsNeuronal lossOlfactory bulb circuitryProjection neuronsPlexiform layerOB glomeruliQuantitative morphometric analysisSynaptic densityGlomerular layerInterneuron subpopulationsOlfactory functionOSN axonsSynaptic inputsSensory cortexOB layersSynaptic circuitsSensory functionOB circuitryCognitive deficits
2003
Impaired Nighttime Sleep in Healthy Old Versus Young Adults Is Associated with Elevated Plasma Interleukin-6 and Cortisol Levels: Physiologic and Therapeutic Implications
Vgontzas A, Zoumakis M, Bixler E, Lin H, Prolo P, Vela-Bueno A, Kales A, Chrousos G. Impaired Nighttime Sleep in Healthy Old Versus Young Adults Is Associated with Elevated Plasma Interleukin-6 and Cortisol Levels: Physiologic and Therapeutic Implications. The Journal Of Clinical Endocrinology & Metabolism 2003, 88: 2087-2095. PMID: 12727959, DOI: 10.1210/jc.2002-021176.Peer-Reviewed Original ResearchConceptsRapid eye movementIL-6Total wake timeTNF-alphaDaytime sleepinessElevated plasma interleukin-6Multiple sleep latency testAssociation of IL-6Rapid eye movement sleepWake timeMeasurement of IL-6Sleep latency testPatterns of IL-6TNF-alpha secretionPlasma IL-6Daytime sleep latencyPlasma interleukin-6Young adultsCortisol plasma concentrationsCortisol levelsIL-6 secretionNocturnal wake timeAge-related alterationsAssociated with elevationLatency test
1999
Developmental aspects of endothelin receptors in rabbit lower urinary tract
Saito M, Latifpour J, Weiss R. Developmental aspects of endothelin receptors in rabbit lower urinary tract. Neurourology And Urodynamics 1999, 19: 71-85. PMID: 10602249, DOI: 10.1002/(sici)1520-6777(2000)19:1<71::aid-nau8>3.0.co;2-9.Peer-Reviewed Original ResearchConceptsLower urinary tractRabbit lower urinary tractEndothelin receptorsUrinary tractBladder baseBladder domeMale rabbitsEndothelin receptor subtypesAge-related alterationsOld male rabbitsET receptorsReceptor subtypesPharmacological characterizationPharmacological profileAged rabbitsSubtype specificityReceptorsTractDevelopment-related changesSimilar proportionsWeeksReceptor compoundsUrethraRabbitsRank order
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