2025
Aldosterone and Aldosterone Modulation in Cardio-Kidney Diseases
Fioretti F, Testani J, Tio M, Pitt B, Butler J. Aldosterone and Aldosterone Modulation in Cardio-Kidney Diseases. Journal Of The American College Of Cardiology 2025, 86: 354-373. PMID: 40738563, DOI: 10.1016/j.jacc.2025.06.012.Peer-Reviewed Original ResearchConceptsMineralocorticoid receptor antagonist therapyMineralocorticoid receptor antagonistsChronic kidney diseaseNonsteroidal mineralocorticoid receptor antagonistAldosterone synthase inhibitorsHeart failureAssociated with progressionExcess aldosteronePartial agonistSynthase inhibitorAssociated with progression of chronic kidney diseaseRenin-angiotensin-aldosterone system inhibitorsRenin-angiotensin-aldosterone system activationProgression of chronic kidney diseaseResistant arterial hypertensionMR-mediated effectsEffects of aldosteroneAssociated with elevationAldosterone levelsNeurohormonal activationProspective trialsReceptor antagonistArterial hypertensionAldosterone productionSystem inhibitors
2003
Impaired Nighttime Sleep in Healthy Old Versus Young Adults Is Associated with Elevated Plasma Interleukin-6 and Cortisol Levels: Physiologic and Therapeutic Implications
Vgontzas A, Zoumakis M, Bixler E, Lin H, Prolo P, Vela-Bueno A, Kales A, Chrousos G. Impaired Nighttime Sleep in Healthy Old Versus Young Adults Is Associated with Elevated Plasma Interleukin-6 and Cortisol Levels: Physiologic and Therapeutic Implications. The Journal Of Clinical Endocrinology & Metabolism 2003, 88: 2087-2095. PMID: 12727959, DOI: 10.1210/jc.2002-021176.Peer-Reviewed Original ResearchConceptsRapid eye movementIL-6Total wake timeTNF-alphaDaytime sleepinessElevated plasma interleukin-6Multiple sleep latency testAssociation of IL-6Rapid eye movement sleepWake timeMeasurement of IL-6Sleep latency testPatterns of IL-6TNF-alpha secretionPlasma IL-6Daytime sleep latencyPlasma interleukin-6Young adultsCortisol plasma concentrationsCortisol levelsIL-6 secretionNocturnal wake timeAge-related alterationsAssociated with elevationLatency test
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