2025
Three-year lifestyle changes, genetic risk, and risk of frailty among older adults: A national community-based cohort study
Zhong W, Wang X, Song W, Chen H, Xie J, Yan H, Wang J, Lv Y, Li Z, Shi X, Mao C. Three-year lifestyle changes, genetic risk, and risk of frailty among older adults: A national community-based cohort study. Clinical Nutrition 2025, 50: 29-37. PMID: 40367593, DOI: 10.1016/j.clnu.2025.04.033.Peer-Reviewed Original ResearchConceptsRisk of frailtyGenetic riskHealthy lifestyleUnhealthy lifestyleOlder adultsFrailty riskLate-lifeLifestyle changesChinese Longitudinal Healthy Longevity SurveyCommunity-based cohort studyHazard ratioPolygenic risk scoresGenetic risk groupsModerate-to-moderatelyCox proportional hazards regression modelsProportional hazards regression modelsLifestyle scoreHazards regression modelsLongevity SurveyHigh frailty riskPrevent frailtyLifestyle factorsFrailty indexCohort studyLifestyle combinationProtective role of parenthood on age-related brain function in mid- to late-life
Orchard E, Chopra S, Ooi L, Chen P, An L, Jamadar S, Yeo B, Rutherford H, Holmes A. Protective role of parenthood on age-related brain function in mid- to late-life. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2411245122. PMID: 39999172, PMCID: PMC11892684, DOI: 10.1073/pnas.2411245122.Peer-Reviewed Original ResearchConceptsBrain functionFunctional connectivityPatterns of brain functionAssociated with higher connectivityConsistent with animal modelsBrain structuresCaregiving environmentAssociated with patternsAge-related alterationsBrain healthAging trajectoriesLate-lifeSpatial topographyAdult brainImpact of caregivingBrainPreliminary findingsHuman parentingImpact of ageCaregiving experienceChildrenCaregiversHigher connectivityEffect of parenthoodOne-bodyIntegrated healthy lifestyle even in late-life mitigates cognitive decline risk across varied genetic susceptibility
Wang J, Chen C, Zhou J, Xu Z, Xu L, Li X, Zhong Z, Lv Y, Shi X. Integrated healthy lifestyle even in late-life mitigates cognitive decline risk across varied genetic susceptibility. Nature Communications 2025, 16: 539. PMID: 39789005, PMCID: PMC11718162, DOI: 10.1038/s41467-024-55763-0.Peer-Reviewed Original ResearchConceptsFavorable lifestyleRate of cognitive declineGenetic riskCognitive declineUnfavorable lifestyleHealthy lifestyleAssociations of combined lifestyle factorsChinese Longitudinal Healthy Longevity SurveyCombined lifestyle factorsHigh genetic riskDimensions of cognitionCognitive decline riskAccelerated cognitive declineLongevity SurveyLifestyle factorsCognitive domainsLate-lifeOlder adultsCognitive functionDeclining riskLifestyleGenetic susceptibilityGenetic factorsRiskCognition
2024
Recommendations on Methods for Assessing Multimorbidity Changes Over Time: Aligning the Method to the Purpose
Nagel C, Bishop N, Botoseneanu A, Allore H, Newsom J, Dorr D, Quiñones A. Recommendations on Methods for Assessing Multimorbidity Changes Over Time: Aligning the Method to the Purpose. The Journals Of Gerontology Series A 2024, 79: glae122. PMID: 38742711, PMCID: PMC11163923, DOI: 10.1093/gerona/glae122.Peer-Reviewed Original ResearchConceptsStudy of multimorbidityHealth-related quality of lifeMeasures of multimorbidityEffect of multimorbidityPerson-centered outcomesHealth-related outcomesHealth-related qualityLongitudinal studyQuality of lifeHealth-related dataMultimorbidity researchHealth domainsMultimorbidityLate-lifePeriod of changeAging populationOperationalizing changeLongitudinal analysisLongitudinal changesMore advanced stagesQuantitative studyOutcomesResearch objectHealthPractical issues
2019
Antidepressants for Anxiety Disorders in Late-Life: A Systematic Review
Balasubramaniam M, Joshi P, Alag P, Gupta S, Maher S, Tampi D, Gupta A, Young J, Tampi R. Antidepressants for Anxiety Disorders in Late-Life: A Systematic Review. Annals Of Clinical Psychiatry 2019, 31: 8-22. DOI: 10.1177/154733251903100314.Peer-Reviewed Original ResearchTreating anxiety disordersLate-life anxietyAnxiety disordersRandomized controlled trials of antidepressantsTolerability of antidepressantsLate-lifeRandomized Controlled TrialsEvaluate antidepressantsAnxiety symptomsAntidepressantsAnxietyLate lifeDisordersOlder adultsControlled TrialsCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsCentre for Evidence-Based MedicineRegister of Controlled TrialsCochrane Central RegisterLong-term useBibliographic databases PubMedEscitalopramCitalopramParoxetine
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