2010
Normalizing Effects of Modafinil on Sleep in Chronic Cocaine Users
Morgan PT, Pace-Schott E, Pittman B, Stickgold R, Malison RT. Normalizing Effects of Modafinil on Sleep in Chronic Cocaine Users. American Journal Of Psychiatry 2010, 167: 331-340. PMID: 20080983, PMCID: PMC5857958, DOI: 10.1176/appi.ajp.2009.09050613.Peer-Reviewed Original ResearchMeSH KeywordsAdultBenzhydryl CompoundsCentral Nervous System StimulantsCocaineCocaine-Related DisordersDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleHumansMaleMiddle AgedModafinilPolysomnographySleep Wake DisordersSubstance Abuse Treatment CentersSubstance Withdrawal SyndromeWakefulnessConceptsMultiple sleep latency testSlow-wave sleep timeSleep latency testEffects of modafinilTotal sleep timeSleep latencyCocaine-dependent participantsSleep timeChronic cocaine usersDaytime sleepinessLatency testCocaine usersShorter REM sleep latencyDaytime sleep latencyLonger total sleep timeREM sleep latencySubjective daytime sleepinessSleep architecture variablesPolysomnographic sleep recordingsSleep architectureNocturnal sleepHealthy comparison participantsAbstinent cocaine usersDay 1Day 2
2006
Daytime napping after a night of sleep loss decreases sleepiness, improves performance, and causes beneficial changes in cortisol and interleukin-6 secretion
Vgontzas A, Pejovic S, Zoumakis E, Lin H, Bixler E, Basta M, Fang J, Sarrigiannidis A, Chrousos G. Daytime napping after a night of sleep loss decreases sleepiness, improves performance, and causes beneficial changes in cortisol and interleukin-6 secretion. AJP Endocrinology And Metabolism 2006, 292: e253-e261. PMID: 16940468, DOI: 10.1152/ajpendo.00651.2005.Peer-Reviewed Original ResearchConceptsMultiple sleep latency testIL-6Night of sleep lossPsychomotor vigilance taskSleep lossLevels of IL-6Sleep latency testIL-6 levelsInterleukin-6 secretionSuppression of IL-6 secretionIL-6 secretionDaytime nappingImprove alertnessNight of total sleep lossYoung healthy individualsLatency testProlonged suppressionInflammatory cytokinesTotal sleep lossInterleukin-6Cortisol secretionHealthy individualsInsulin resistanceTransient increaseBlood samples
2004
Marked Decrease in Sleepiness in Patients with Sleep Apnea by Etanercept, a Tumor Necrosis Factor-α Antagonist
Vgontzas A, Zoumakis E, Lin H, Bixler E, Trakada G, Chrousos G. Marked Decrease in Sleepiness in Patients with Sleep Apnea by Etanercept, a Tumor Necrosis Factor-α Antagonist. The Journal Of Clinical Endocrinology & Metabolism 2004, 89: 4409-4413. PMID: 15356039, DOI: 10.1210/jc.2003-031929.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaMultiple sleep latency testSleep latency testC-reactive proteinIL-6Sleep apneaLatency testEffect of continuous positive airway pressureProinflammatory cytokinesMediators of excessive daytime sleepinessTumor necrosis factor-a antagonistsContinuous positive airway pressurePlasma levels of IL-6Plasma C-reactive proteinBlood glucosePositive airway pressureEffect of etanerceptLevels of IL-6Double-blind studyLevels of fasting blood glucoseIL-6 levelsExcessive daytime sleepinessFasting blood glucoseIncreased sleep latencyTreatment of rheumatoid arthritis
2003
Impaired Nighttime Sleep in Healthy Old Versus Young Adults Is Associated with Elevated Plasma Interleukin-6 and Cortisol Levels: Physiologic and Therapeutic Implications
Vgontzas A, Zoumakis M, Bixler E, Lin H, Prolo P, Vela-Bueno A, Kales A, Chrousos G. Impaired Nighttime Sleep in Healthy Old Versus Young Adults Is Associated with Elevated Plasma Interleukin-6 and Cortisol Levels: Physiologic and Therapeutic Implications. The Journal Of Clinical Endocrinology & Metabolism 2003, 88: 2087-2095. PMID: 12727959, DOI: 10.1210/jc.2002-021176.Peer-Reviewed Original ResearchConceptsRapid eye movementIL-6Total wake timeTNF-alphaDaytime sleepinessElevated plasma interleukin-6Multiple sleep latency testAssociation of IL-6Rapid eye movement sleepWake timeMeasurement of IL-6Sleep latency testPatterns of IL-6TNF-alpha secretionPlasma IL-6Daytime sleep latencyPlasma interleukin-6Young adultsCortisol plasma concentrationsCortisol levelsIL-6 secretionNocturnal wake timeAge-related alterationsAssociated with elevationLatency testDaytime testing after laboratory or home‐based polysomnography: comparisons of middle‐aged insomnia sufferers and normal sleepers
Edinger JD, Glenn DM, Bastian LA, Marsh GR, Dailey D, Hope TV, Young M, Shaw E, Meeks G. Daytime testing after laboratory or home‐based polysomnography: comparisons of middle‐aged insomnia sufferers and normal sleepers. Journal Of Sleep Research 2003, 12: 43-52. PMID: 12603786, DOI: 10.1046/j.1365-2869.2003.00335.x.Peer-Reviewed Original ResearchConceptsMultiple sleep latency testInsomnia sufferersNormal sleepersDaytime multiple sleep latency testSleep latency testNormal control groupHome-based polysomnographyPersistent primary insomniaLatency testPrimary insomniaNormal controlsReaction time testControl groupDaytime testingInterview criteriaStudy participantsMatched-groups designSleep labPolysomnographSufferersSleep settingsSuch testingModest differencesCurrent studyParticipants
1992
The Effect of Short-term Nasal CPAP on Cheyne-Stokes Respiration in Congestive Heart Failure
Buckle P, Millar T, Kryger M. The Effect of Short-term Nasal CPAP on Cheyne-Stokes Respiration in Congestive Heart Failure. CHEST Journal 1992, 102: 31-35. PMID: 1623779, DOI: 10.1378/chest.102.1.31.Peer-Reviewed Original ResearchConceptsCongestive heart failureCheyne-Stokes respirationMultiple sleep latency testNasal CPAPSleep qualityNocturnal oxygenationHeart failureTreatment nightsDaytime arterial blood gas valuesArterial blood gas valuesNasal CPAP therapyNYHA class 3Sleep latency testBlood gas valuesShort-term treatmentSignificant differencesAge 54.1CPAP therapyMale patientsFull polysomnographyDaytime sleepinessLatency testCPAPPatientsGas values
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