Effects of diet-induced obesity in the development of lymphedema in the animal model: A literature review
Khan N, Huayllani MT, Lu X, Boczar D, Cinotto G, Avila FR, Guliyeva G, Forte AJ. Effects of diet-induced obesity in the development of lymphedema in the animal model: A literature review. Obesity Research & Clinical Practice 2022, 16: 197-205. PMID: 35659463, DOI: 10.1016/j.orcp.2022.05.003.Peer-Reviewed Original ResearchConceptsAerobic exerciseT cellsAnimal modelsLymphatic dysfunctionEffect of obesityLipid metabolism disordersDiet-induced obesityHigh-fat dietDevelopment of lymphedemaAdipose tissue depositionVEGFR-3 expressionImpaired lymphatic drainageInhibition of lymphangiogenesisUnderlying cellular mechanismsInflammatory cascadeOvid EmbaseDiet/Metabolism disordersPharmacological interventionsEligibility criteriaLymphatic drainageContractile propertiesLong-term exposureObesityLymphatic endothelial cellsActivation of the CaMKII-Sarm1-ASK1-p38 MAP kinase pathway protects against axon degeneration caused by loss of mitochondria
Ding C, Wu Y, Dabas H, Hammarlund M. Activation of the CaMKII-Sarm1-ASK1-p38 MAP kinase pathway protects against axon degeneration caused by loss of mitochondria. ELife 2022, 11: e73557. PMID: 35285800, PMCID: PMC8920508, DOI: 10.7554/elife.73557.Peer-Reviewed Original ResearchConceptsMAPK pathwayLoss of mitochondriaMitochondrial defectsUnbiased genetic screenMAP kinase pathwayCell-specific activationTrafficking complexGenetic screenCEBP-1Kinase pathwayUnderlying cellular mechanismsCellular mechanismsL-type voltage-gated calcium channelsMitochondriaVoltage-gated calcium channelsPathwayUNCAxon degenerationCaenorhabditisActivationCalcium channelsFurther analysisTraffickingSuppressesCaMKII
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