2025
PET imaging evidence of HDAC6 suppression in the amygdala across species in PTSD
Bonomi R, Naganawa M, McRiley D, Toyonaga T, LeVasseur B, Duman C, Huang Y, Matuskey D, Carson R, Pietrzak R, Girgenti M, Cosgrove K. PET imaging evidence of HDAC6 suppression in the amygdala across species in PTSD. Molecular Psychiatry 2025, 1-8. PMID: 40753309, DOI: 10.1038/s41380-025-03124-8.Peer-Reviewed Original ResearchPosttraumatic stress disorderPathophysiology of posttraumatic stress disorderNon-trauma-exposed controlsAmygdala of individualsProlonged stress modelBrain imaging studiesStress disorderRodent findingsNuclear translocation of glucocorticoid receptorTranslocation of glucocorticoid receptorHuman findingsTranslational findingsCortisol signalingAmygdalaGlucocorticoid receptorComplex disorderImaging studiesDisordersLongitudinal analysisStress modelHistone deacetylase 6Pharmacological targetsHistone deacetylasesFindingsNuclear translocation
2024
Deficits in brain glucose transport among younger adults with obesity
Gunawan F, Matson B, Coppoli A, Jiang L, Ding Y, Perry R, Sanchez‐Rangel E, DeAguiar R, Behar K, Rothman D, Mason G, Hwang J. Deficits in brain glucose transport among younger adults with obesity. Obesity 2024, 32: 1329-1338. PMID: 38764181, PMCID: PMC11966602, DOI: 10.1002/oby.24034.Peer-Reviewed Original ResearchBrain glucose transportLean participantsMarkers of insulin resistanceMagnetic resonance spectroscopy scansEffect of obesityAssociated with alterationsLong-term brain functionCerebral glucose metabolic rateGlucose transportGlucose metabolic rateCardiometabolic comorbiditiesBrain energy utilizationPeripheral markersHyperglycemic clampInsulin resistanceObesityBrain glucose uptakeHuman findingsEating behaviorsYounger ageYoung healthy participantsNeurocognitive functionGlucose transport capacityBrain functionNonesterified fatty acids
2018
G-Protein-Coupled Receptor CXCR7 Is Overexpressed in Human and Murine Endometriosis
Pluchino N, Mamillapalli R, Moridi I, Tal R, Taylor HS. G-Protein-Coupled Receptor CXCR7 Is Overexpressed in Human and Murine Endometriosis. Reproductive Sciences 2018, 25: 1168-1174. PMID: 29587613, PMCID: PMC6346303, DOI: 10.1177/1933719118766256.Peer-Reviewed Original ResearchConceptsG protein-coupled receptorsNormal endometrial epitheliumChronic inflammatory diseaseOverexpression of CXCR7Chemokine ligand CXCL12Chemokine G-protein-coupled receptorsMurine endometriosisDifferent cellular populationsHuman endometriosisInflammatory diseasesMenstrual cycleChemokine receptorsReceptor CXCR7Endometrial epitheliumEndometriosis pathogenesisLigand CXCL12Murine modelMouse modelEndometriosisHigher stainingCXCR7Human findingsCell traffickingLow expressionNovel target
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