2020
Resting state hypothalamic and dorsomedial prefrontal cortical connectivity of the periaqueductal gray in cocaine addiction
Zhang S, Zhornitsky S, Wang W, Le TM, Dhingra I, Chen Y, Li C. Resting state hypothalamic and dorsomedial prefrontal cortical connectivity of the periaqueductal gray in cocaine addiction. Addiction Biology 2020, 26: e12989. PMID: 33300238, PMCID: PMC8614224, DOI: 10.1111/adb.12989.Peer-Reviewed Original ResearchConceptsPeriaqueductal grayPain circuitsDrug useCocaine addictionFunctional connectivityPrefrontal cortical connectivityState functional connectivityReward circuit dysfunctionRecent cocaine useHealthy control participantsInferior parietal cortexCompulsive drug useHabitual drug useCircuit dysfunctionCocaine withdrawalCocaine-dependent individualsCocaine cravingCortical connectivitySignificant anxietyDorsomedial prefrontalParietal cortexCocaine useIntrinsic connectivitySubcortical hubsDrug seeking
2014
Chapter Six The Role of Guanfacine as a Therapeutic Agent to Address Stress-Related Pathophysiology in Cocaine-Dependent Individuals
Fox H, Sinha R. Chapter Six The Role of Guanfacine as a Therapeutic Agent to Address Stress-Related Pathophysiology in Cocaine-Dependent Individuals. Advances In Pharmacology 2014, 69: 217-265. PMID: 24484979, PMCID: PMC4017947, DOI: 10.1016/b978-0-12-420118-7.00006-8.Peer-Reviewed Original ResearchConceptsCocaine-dependent individualsAdaptive goal-directed behaviorNegative emotional statesGoal-directed behaviorCompulsive drug useDrug-seeking behaviorCocaine dependenceStress-related pathophysiologyCognitive regulationNegative affectEmotional controlEmotional statesAnxiety pathophysiologyPrefrontal cortexDrugs of abuseNeural systemsBehavioral processesRecent research findingsBrain regionsCocaine addictionGuanfacinePolydrug abusersResearch findingsCocaine withdrawal symptomsDrug use
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