Machine Learning Analysis of the Orbitofrontal Cortex Transcriptome of Human Opioid Users Identifies Shisa7 as a Translational Target Relevant for Heroin Seeking Leveraging a Male Rat Model
Ellis R, Ferland J, Rahman T, Landry J, Callens J, Pandey G, Lam T, Kanyo J, Nairn A, Dracheva S, Hurd Y. Machine Learning Analysis of the Orbitofrontal Cortex Transcriptome of Human Opioid Users Identifies Shisa7 as a Translational Target Relevant for Heroin Seeking Leveraging a Male Rat Model. Biological Psychiatry 2024, 98: 23-33. PMID: 39725299, DOI: 10.1016/j.biopsych.2024.12.007.Peer-Reviewed Original ResearchRat orbitofrontal cortexOrbitofrontal cortexOpioid use disorderHeroin seekingBehavioral updatingHeroin usersHeroin-seeking behaviorDrug-seeking behaviorGoal-directed behaviorNeurobiological targetsOperant contingenciesUse disorderControl participantsTranslational rat modelGABAergic receptor subunitsHeroin useNeuroimmune processesShisa7AMPA receptorsMale rat modelReceptor subunitsSeekingGene expression signaturesOpioid usersHeroin
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