2024
Branching in poly(amine-co-ester) polyplexes impacts mRNA transfection
Shin K, Suh H, Suberi A, Whang C, Ene M, Grundler J, Grun M, Saltzman W. Branching in poly(amine-co-ester) polyplexes impacts mRNA transfection. Biomaterials 2024, 311: 122692. PMID: 38986360, PMCID: PMC11298310, DOI: 10.1016/j.biomaterials.2024.122692.Peer-Reviewed Original ResearchPolymer branchingTransfection in vivoPhysicochemical propertiesPoly(amine-co-esterMRNA deliveryTerminal groupsPolymer featuresIn vitroPolymerNucleic acid deliveryMonomer compositionAnalysis of physicochemical propertiesStructural parametersCationic polymersStability of polyplexesMRNA transfectionTransfection efficiencyAcid deliveryDelivery vehiclesTransfectionMRNA
2012
Synthesis and evaluation of 11β-(4-Substituted phenyl) estradiol analogs: Transition from estrogen receptor agonists to antagonists
Hanson RN, Hua E, Hendricks JA, Labaree D, Hochberg RB. Synthesis and evaluation of 11β-(4-Substituted phenyl) estradiol analogs: Transition from estrogen receptor agonists to antagonists. Bioorganic & Medicinal Chemistry 2012, 20: 3768-3780. PMID: 22608920, PMCID: PMC3581310, DOI: 10.1016/j.bmc.2012.04.041.Peer-Reviewed Original ResearchConceptsSynthetic strategyNew compoundsERα-LBDPotential drug delivery systemPrevious synthetic studiesSeries of compoundsDrug delivery systemsClass of compoundsSynthetic methodTerminal groupsFacile accessSynthetic studiesDrug conjugationSpecific structural featuresCompetitive ligandCompoundsSteroidal agonistsDelivery systemRepresentative scaffoldsStructural featuresERβ-LBDSubtype selectivityActive groupAnaloguesScaffolds
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