2005
Use of an implantable drug delivery system for refractory chronic sickle cell pain
Smith TJ, Coyne PJ, Smith WR, Roberts JD, Smith V. Use of an implantable drug delivery system for refractory chronic sickle cell pain. American Journal Of Hematology 2005, 78: 153-154. PMID: 15682408, DOI: 10.1002/ajh.20252.Peer-Reviewed Original ResearchConceptsImplantable intrathecal drug delivery systemsSickle cell patientsCell patientsChronic sickle cell painIntrathecal drug delivery systemsRefractory bone painRefractory cancer painSustained-release opioidsSickle cell painRandomized clinical trialsComprehensive medical managementBone painCancer painRefractory painProspective trialSustained reliefMedical managementCancer patientsDrug delivery systemsClinical trialsPainClinical successPatientsDelivery systemImplantable drug delivery systems
1982
Implantable Insulin Infusion Devices
Blackshear P, Nathan D, Cohen A, Hurxthal K, Shulman G. Implantable Insulin Infusion Devices. JAMA 1982, 248: 2111-2111. PMID: 7120635, DOI: 10.1001/jama.1982.03330170019006.Peer-Reviewed Original ResearchConceptsInsulin infusion devicesInfusion devicesSimilar glycemic controlIntensive conventional therapyImplantation of devicesGlycemic controlSubstantial morbidityConventional therapyInsulin delivery systemsAnimal studiesClinical useDelivery systemLong-term studiesImplantable drug delivery systemsResearch protocolDrug delivery systemsExtreme cautionImplantationMorbidityTherapyMortality
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