2024
Intensive longitudinal assessment following index trauma to predict development of PTSD using machine learning
Horwitz A, McCarthy K, House S, Beaudoin F, An X, Neylan T, Clifford G, Linnstaedt S, Germine L, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Swor R, Hudak L, Pascual J, Seamon M, Harris E, Pearson C, Peak D, Domeier R, Rathlev N, Sergot P, Sanchez L, Bruce S, Joormann J, Harte S, Koenen K, McLean S, Sen S. Intensive longitudinal assessment following index trauma to predict development of PTSD using machine learning. Journal Of Anxiety Disorders 2024, 104: 102876. PMID: 38723405, PMCID: PMC11215748, DOI: 10.1016/j.janxdis.2024.102876.Peer-Reviewed Original ResearchTraumatic exposureIntensive longitudinal assessmentDevelopment of PTSDTrauma-related symptomsExposure to traumaFollow-up careTrauma exposureIndex traumaEmergency carePTSDAssess symptomsLongitudinal assessmentAssessment protocolCareParticipantsSymptomsFollow-upInterventionMachine learning analysisTraumaRiskIndividualsWeeksLearning analysisNervousness
2022
Structural covariance of the ventral visual stream predicts posttraumatic intrusion and nightmare symptoms: a multivariate data fusion analysis
Harnett NG, Finegold KE, Lebois LAM, van Rooij SJH, Ely TD, Murty VP, Jovanovic T, Bruce SE, House SL, Beaudoin FL, An X, Zeng D, Neylan TC, Clifford GD, Linnstaedt SD, Germine LT, Bollen KA, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI, Hendry PL, Sheikh S, Jones CW, Punches BE, Kurz MC, Swor RA, Hudak LA, Pascual JL, Seamon MJ, Harris E, Chang AM, Pearson C, Peak DA, Domeier RM, Rathlev NK, O’Neil B, Sergot P, Sanchez LD, Miller MW, Pietrzak RH, Joormann J, Barch DM, Pizzagalli DA, Sheridan JF, Harte SE, Elliott JM, Kessler RC, Koenen KC, McLean SA, Nickerson LD, Ressler KJ, Stevens JS. Structural covariance of the ventral visual stream predicts posttraumatic intrusion and nightmare symptoms: a multivariate data fusion analysis. Translational Psychiatry 2022, 12: 321. PMID: 35941117, PMCID: PMC9360028, DOI: 10.1038/s41398-022-02085-8.Peer-Reviewed Original ResearchConceptsVentral visual streamPosttraumatic stress disorderVisual streamTrauma memoriesStructural covariance networksPTSD symptomsDevelopment of PTSDVisual componentsHigher PTSD symptom severityMultimodal magnetic resonance imaging (MRI) dataPTSD symptom severityFunctional covariance networkInferior temporal gyrusAdverse posttraumatic neuropsychiatric sequelaeCovariance networksPosttraumatic intrusionsTrauma exposureIntrusion symptomsStress disorderTemporal gyrusMagnetic resonance imaging dataNegative alterationsAffective disturbancesNightmare symptomsSymptom severityInfluences of Aging on PTSD Prevalence, Neurobiology, and Clinical Course
Rutherford B, Cook J, Simiola V, Zhu X. Influences of Aging on PTSD Prevalence, Neurobiology, and Clinical Course. American Journal Of Geriatric Psychiatry 2022, 30: s5-s6. DOI: 10.1016/j.jagp.2022.01.258.Peer-Reviewed Original ResearchPosttraumatic stress disorderTrauma-exposed healthy controlsChronic posttraumatic stress disorderOlder adultsMajor depressive disorderYoung adultsDevelopment of PTSDTreatment of PTSDSelective serotonin reuptake inhibitorsExposure-based psychotherapyNetwork connectivity differencesSexual assault survivorsProlonged exposure therapyEvidence-based psychotherapiesPhysical functioning trajectoriesIntrusive thoughtsExposure therapyMental health settingsHalf of veteransAssault survivorsStress disorderTraumatic experiencesTraumatic stimuliAge-related changesSignificant functional impairmentAltered gene expression and PTSD symptom dimensions in World Trade Center responders
Marchese S, Cancelmo L, Diab O, Cahn L, Aaronson C, Daskalakis NP, Schaffer J, Horn SR, Johnson JS, Schechter C, Desarnaud F, Bierer LM, Makotkine I, Flory JD, Crane M, Moline JM, Udasin IG, Harrison DJ, Roussos P, Charney DS, Koenen KC, Southwick SM, Yehuda R, Pietrzak RH, Huckins LM, Feder A. Altered gene expression and PTSD symptom dimensions in World Trade Center responders. Molecular Psychiatry 2022, 27: 2225-2246. PMID: 35177824, DOI: 10.1038/s41380-022-01457-2.Peer-Reviewed Original ResearchConceptsPTSD symptom dimensionsPosttraumatic stress disorderCAPS scoresAnxious arousal symptomsSymptom dimensionsWorld Trade Center rescueClinician-Administered PTSD Scale scoresBiomarker of PTSDArousal symptomsCD4 T cellsWorld Trade Center respondersDevelopment of PTSDTotal CAPS scoresCase/control statusTherapeutic target developmentIdentification of biomarkersClinical interview dataResponder cohortPTSD symptom severityPotential biological differencesWTC respondersT cellsGene expressionPTSD studiesPsychiatric disorders
2021
Attachment Style Moderates Polygenic Risk for Incident Posttraumatic Stress in U.S. Military Veterans: A 7-Year, Nationally Representative, Prospective Cohort Study
Tamman AJF, Wendt FR, Pathak GA, Krystal JH, Southwick SM, Sippel LM, Gelernter J, Polimanti R, Pietrzak RH. Attachment Style Moderates Polygenic Risk for Incident Posttraumatic Stress in U.S. Military Veterans: A 7-Year, Nationally Representative, Prospective Cohort Study. Biological Psychiatry 2021, 91: 637-646. PMID: 34955171, DOI: 10.1016/j.biopsych.2021.09.025.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAttachment styleU.S. military veteransIncident posttraumatic stress disorderSocial environmental factorsDevelopment of PTSDMilitary veteransInsecure attachment stylesSecure attachment stylePolygenic riskEffect of PRSLifetime trauma burdenPTSD preventionPosttraumatic stressPTSD developmentPTSD symptomsStress disorderPolygenic risk scoresHigh polygenic riskProspective designNationally RepresentativePotential pharmacotherapyMultivariate geneStyleVeteransThe impact of sleep quality on the incidence of PTSD: Results from a 7-Year, Nationally Representative, Prospective Cohort of U.S. Military Veterans
DeViva JC, McCarthy E, Southwick SM, Tsai J, Pietrzak RH. The impact of sleep quality on the incidence of PTSD: Results from a 7-Year, Nationally Representative, Prospective Cohort of U.S. Military Veterans. Journal Of Anxiety Disorders 2021, 81: 102413. PMID: 33991819, PMCID: PMC10693322, DOI: 10.1016/j.janxdis.2021.102413.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderSleep qualityNew-onset posttraumatic stress disorderIncidence of PTSDSelf-reported sleep qualityProspective cohort studyProbable posttraumatic stress disorderPoor sleep qualityPotential risk factorsDevelopment of PTSDU.S. veteran populationFair sleep qualityWave 1U.S. military veteransCohort studyProspective cohortIndependent determinantsClinical variablesRisk factorsNational HealthLifetime depressionVeteran populationMultivariate analysisU.S. veteransGreater trauma
2020
Dissociative symptoms predict risk for the development of PTSD: Results from the National Health and Resilience in Veterans Study (NHRVS)
Herzog S, Fogle BM, Harpaz-Rotem I, Tsai J, DePierro J, Pietrzak RH. Dissociative symptoms predict risk for the development of PTSD: Results from the National Health and Resilience in Veterans Study (NHRVS). Journal Of Psychiatric Research 2020, 131: 215-219. PMID: 32998083, DOI: 10.1016/j.jpsychires.2020.09.018.Peer-Reviewed Original ResearchConceptsDevelopment of PTSDPosttraumatic stress disorderU.S. military veteransDissociative symptomsRisk factorsDerealization symptomsIncident posttraumatic stress disorderTrauma exposureImmutable risk factorsProspective cohort studyPopulation-based risk factorsMilitary veteransPrediction of PTSDPotential clinical utilityTrauma-related factorsTrauma-exposed veteransCohort studyNational HealthRelative riskClinical utilityU.S. veteransVeterans StudySymptomsTrauma characteristicsStress disorder
2018
Role of endocannabinoids in the hippocampus and amygdala in emotional memory and plasticity
Segev A, Korem N, Mizrachi Zer-Aviv T, Abush H, Lange R, Sauber G, Hillard C, Akirav I. Role of endocannabinoids in the hippocampus and amygdala in emotional memory and plasticity. Neuropsychopharmacology 2018, 43: 2017-2027. PMID: 29977073, PMCID: PMC6098035, DOI: 10.1038/s41386-018-0135-4.Peer-Reviewed Original ResearchConceptsLong-term potentiationPosttraumatic stress disorderBasolateral amygdalaSituational remindersEmotional memoryFatty acid amide hydrolase inhibitor URB597Fear responsesCB1 receptor antagonist AM251Effects of URB597Receptor antagonist AM251Role of endocannabinoidsDevelopment of PTSDHippocampal CA1 areaTrauma-related cuesEndogenous cannabinoid levelsSevere footshockAntagonist AM251Endocannabinoid contentAEA levelsCA1 areaEffects of exposureRisk factorsFAAH activityTreatment responseFAAH inhibition
2015
Gene networks specific for innate immunity define post-traumatic stress disorder
Breen MS, Maihofer AX, Glatt SJ, Tylee DS, Chandler SD, Tsuang MT, Risbrough VB, Baker DG, O'Connor DT, Nievergelt CM, Woelk CH. Gene networks specific for innate immunity define post-traumatic stress disorder. Molecular Psychiatry 2015, 20: 1538-1545. PMID: 25754082, PMCID: PMC4565790, DOI: 10.1038/mp.2015.9.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderPTSD developmentStress disorderExpression of genesDevelopment of PTSDEarly preventative measuresPeripheral blood leukocytesInnate immune responseProper wound healingProspective experimental designClinical indicatorsRNA-seq gene expressionHemostatic systemBlood leukocytesInnate immuneCausal pathophysiologyMechanisms of PTSDCo-regulated genesInnate immunityPrevious transcriptomic studiesTrauma exposureCo-expression modulesU.S. MarinesPreventative measuresWound healing
2005
Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors
Segman RH, Shefi N, Goltser-Dubner T, Friedman N, Kaminski N, Shalev AY. Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors. Molecular Psychiatry 2005, 10: 500-513. PMID: 15685253, DOI: 10.1038/sj.mp.4001636.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdolescentAdultFollow-Up StudiesGene Expression ProfilingGenetic MarkersHumansLeukocytes, MononuclearLife Change EventsMiddle AgedOligonucleotide Array Sequence AnalysisPredictive Value of TestsSeverity of Illness IndexStress Disorders, Post-TraumaticStress, PsychologicalSurvivorsConceptsGene expression signaturesPeripheral blood mononuclear cell gene expressionExpression signaturesTrauma survivorsPeripheral blood mononuclear cell gene expression profilesTime pointsDSM-IV diagnostic criteriaKey clinical featuresPost-traumatic stress disorder symptomsPost-traumatic stress disorderCell gene expression profilesClinical featuresOutcome predictorsEmergency roomPTSD symptom clustersDevelopment of PTSDPathogenetic implicationsDiagnostic criteriaChronic PTSDDiagnostic utilityEarly symptomsMental disordersNeuropsychiatric disordersSymptom clustersPTSD criteria
2002
Psychobiology of the acute stress response and its relationship to the psychobiology of post-traumatic stress disorder
Marshall RD, Garakani A. Psychobiology of the acute stress response and its relationship to the psychobiology of post-traumatic stress disorder. Psychiatric Clinics Of North America 2002, 25: 385-395. PMID: 12136506, DOI: 10.1016/s0193-953x(01)00005-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsBaseline cortisolLow baseline cortisolChronic PTSDDevelopment of PTSDStartle responseChronic medical conditionsBrief psychosocial interventionStandard of careAcute PTSD symptomsHPA axis functioningPost-traumatic eventsPost-traumatic stress disorderNormal circadian rhythmAcute stress reactionsEtiology of PTSDAcute stress responseLevel of symptomatologyAcute settingPharmacologic treatmentPharmacologic interventionsEtiologic roleSerial assessmentPersistent alterationsMedical conditionsStria terminalis
1999
Glutamate and post-traumatic stress disorder: toward a psychobiology of dissociation.
Chambers RA, Bremner JD, Moghaddam B, Southwick SM, Charney DS, Krystal JH. Glutamate and post-traumatic stress disorder: toward a psychobiology of dissociation. Seminars In Clinical Neuropsychiatry 1999, 4: 274-81. PMID: 10553033, DOI: 10.153/scnp00400274.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderGlutamate releaseNMDA antagonistsStress disorderN-methyl-D-aspartate (NMDA) subtypeDevelopment of PTSDDissociative symptomsStress exposureRecent preclinical dataTraumatic stress exposureHyperglutamatergic stateNeuroprotective potentialPreclinical dataNeural toxicityClinical studiesGlutamate receptorsTraumatized individualsPerceptual effectsPerceptual alterationsNeural plasticityAntagonistBrain functionSymptomsInfluence behaviorDrugs
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