2024
Functional correlates of a novel 8-factor model of PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Stiltner B, Fischer I, Duek O, Polimanti R, Harpaz-Rotem I, Pietrzak R. Functional correlates of a novel 8-factor model of PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Journal Of Psychiatric Research 2024, 171: 69-74. PMID: 38244335, DOI: 10.1016/j.jpsychires.2024.01.017.Peer-Reviewed Original ResearchConceptsModels of posttraumatic stress disorderPosttraumatic stress disorderNational Health and ResilienceU.S. military veteransArousal symptomsSuicidal ideationVeterans StudyCurrent depressionSymptom clustersMilitary veteransPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder symptomsPosttraumatic Stress Disorder ChecklistAnxious arousal symptomsDysphoric arousal symptomsIntrusive symptom clustersOdds of suicidal ideationFunctional correlatesMulti-faceted disorderExternalizing behavioral symptomsAssociated with lower oddsAssociated with higher oddsSymptom structureAvoidance symptomsDSM-5
2022
Altered gene expression and PTSD symptom dimensions in World Trade Center responders
Marchese S, Cancelmo L, Diab O, Cahn L, Aaronson C, Daskalakis NP, Schaffer J, Horn SR, Johnson JS, Schechter C, Desarnaud F, Bierer LM, Makotkine I, Flory JD, Crane M, Moline JM, Udasin IG, Harrison DJ, Roussos P, Charney DS, Koenen KC, Southwick SM, Yehuda R, Pietrzak RH, Huckins LM, Feder A. Altered gene expression and PTSD symptom dimensions in World Trade Center responders. Molecular Psychiatry 2022, 27: 2225-2246. PMID: 35177824, DOI: 10.1038/s41380-022-01457-2.Peer-Reviewed Original ResearchConceptsPTSD symptom dimensionsPosttraumatic stress disorderCAPS scoresAnxious arousal symptomsSymptom dimensionsWorld Trade Center rescueClinician-Administered PTSD Scale scoresBiomarker of PTSDArousal symptomsCD4 T cellsWorld Trade Center respondersDevelopment of PTSDTotal CAPS scoresCase/control statusTherapeutic target developmentIdentification of biomarkersClinical interview dataResponder cohortPTSD symptom severityPotential biological differencesWTC respondersT cellsGene expressionPTSD studiesPsychiatric disorders
2021
Coping Strategies, Neural Structure, and Depression and Anxiety During the COVID-19 Pandemic: A Longitudinal Study in a Naturalistic Sample Spanning Clinical Diagnoses and Subclinical Symptoms
Holt-Gosselin B, Tozzi L, Ramirez CA, Gotlib IH, Williams LM. Coping Strategies, Neural Structure, and Depression and Anxiety During the COVID-19 Pandemic: A Longitudinal Study in a Naturalistic Sample Spanning Clinical Diagnoses and Subclinical Symptoms. Biological Psychiatry Global Open Science 2021, 1: 261-271. PMID: 34604834, PMCID: PMC8479487, DOI: 10.1016/j.bpsgos.2021.06.007.Peer-Reviewed Original ResearchAnxious arousal symptomsMaladaptive coping strategiesArousal symptomsCoping strategiesSubclinical symptomsBrain regionsNeural structuresGray matter volumePreregistered hypothesesNeural factorsAnhedonia symptomsStressful eventsDepression symptomsGeneral linear mixed-effects modelsNaturalistic sampleLongitudinal studyMatter volumeAmygdala volumeAnxietyLower structural integrityCOVID-19 pandemicT1-weighted scansCortical thicknessPsychiatric diagnosisClinical symptomsCannabinoid Receptor 1 rs1049353 Variant, Childhood Abuse, and the Heterogeneity of PTSD Symptoms: Results From the National Health and Resilience in Veterans Study
Korem N, Duek O, Xu K, Harpaz-Rotem I, Pietrzak RH. Cannabinoid Receptor 1 rs1049353 Variant, Childhood Abuse, and the Heterogeneity of PTSD Symptoms: Results From the National Health and Resilience in Veterans Study. Chronic Stress 2021, 5: 24705470211011075. PMID: 33997583, PMCID: PMC8107935, DOI: 10.1177/24705470211011075.Peer-Reviewed Original ResearchPosttraumatic stress disorderOverall PTSD symptomsAnxious arousal symptomsPTSD symptomsNational HealthChildhood abuseVeterans StudySymptom clustersArousal symptomsAllele carrier statusArousal symptom clustersMultivariable analysisEndocannabinoid systemAllele carriersPTSD symptom clustersGene-environment studiesGreater severityG homozygotesU.S. veteransSymptomsStress disorderCarrier statusReceptor geneDisordersSignificant main effect
2020
Self‐reported exercise frequency and PTSD: results from the National Health and Resilience in Veterans Study
Adams T, Forte J, Fogle B, Southwick S, Pietrzak R. Self‐reported exercise frequency and PTSD: results from the National Health and Resilience in Veterans Study. Acta Psychiatrica Scandinavica 2020, 142: 486-495. PMID: 32961606, DOI: 10.1111/acps.13234.Peer-Reviewed Original ResearchConceptsProbable posttraumatic stress disorderPosttraumatic stress disorderSelf-reported exercise frequencyExercise frequencyNational HealthDaily exercisePhysical exerciseGreater severityVeterans StudyDays/weekMilitary veteransPopulation-based sampleAnxious arousal symptomsU.S. military veteransWeekly exerciseRe-experiencing symptomsU.S. veteransClinical implicationsProtective factorsStress disorderArousal symptomsCross-sectional dataPrevalenceSeverityVeterans
2018
The Unique Roles of Emotional Numbing and Arousal Symptoms in Relation to Social Connectedness Among Military Veterans in Residential Treatment for PTSD
Sippel LM, Watkins LE, Pietrzak RH, Hoff R, Harpaz-Rotem I. The Unique Roles of Emotional Numbing and Arousal Symptoms in Relation to Social Connectedness Among Military Veterans in Residential Treatment for PTSD. Psychiatry 2018, 81: 271-282. PMID: 30015602, DOI: 10.1080/00332747.2017.1395313.Peer-Reviewed Original ResearchConceptsPTSD symptom clustersDysphoric arousal symptomsPoor social connectednessArousal symptomsEmotional numbingSocial connectednessResidential treatmentPosttraumatic stress disorder (PTSD) symptomsSymptom clustersEmotional numbing symptomsMilitary veteransAnxious arousal symptomsFive-factor modelU.S. military veteransAnxious arousalDysphoric arousalNumbing symptomsInterpersonal functioningTrauma recoveryDisorder symptomsCase conceptualizationGreater distressMore distressPTSDSupportive people
2017
Neuroeconomic approach to trauma related psychopathology: A version to ambiguous losses in PTSD
Harpaz-Rotem I, Jia R, Ruderman L, Pietrzak R, Levy I. Neuroeconomic approach to trauma related psychopathology: A version to ambiguous losses in PTSD. European Psychiatry 2017, 41: s358. DOI: 10.1016/j.eurpsy.2017.02.349.Peer-Reviewed Original ResearchAnxious arousal symptomsArousal symptomsAmbiguity attitudesCombat exposureTrauma-related symptomatologyTrauma-related psychopathologyTrauma-related symptomsWhole-brain analysisBehavioral economics techniquesSeverity of PTSDDisclosure of interestNeuroeconomic approachNeural underpinningsTraditional diagnostic categoriesSpecific brain areasCombat veteransRelated psychopathologyAmbiguous optionBehavioral outcomesFMRI dataBrain analysisPTSDLoss domainAmbiguous lossBrain areas
2016
POSTTRAUMATIC STRESS SYMPTOMS AND AVERSION TO AMBIGUOUS LOSSES IN COMBAT VETERANS
Ruderman L, Ehrlich DB, Roy A, Pietrzak RH, Harpaz-Rotem I, Levy I. POSTTRAUMATIC STRESS SYMPTOMS AND AVERSION TO AMBIGUOUS LOSSES IN COMBAT VETERANS. Depression And Anxiety 2016, 33: 606-613. PMID: 27000639, PMCID: PMC5247796, DOI: 10.1002/da.22494.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderCombat veteransAmbiguity attitudesCombat exposureDecision-making taskTrauma-related symptomsAnxious arousal symptomsBehavioral economics techniquesUncertainty attitudesAnxious arousalNeural underpinningsTraditional diagnostic categoriesArousal symptomsStress disorderBehavioral levelBehavioral outcomesParticipants' choicesLoss domainBehavioral economicsPsychiatric symptomsVeteransAttitudesPsychiatric disordersUncertain outcomesUncertain gains
2013
Association of Posttraumatic Stress Disorder With Reduced In Vivo Norepinephrine Transporter Availability in the Locus Coeruleus
Pietrzak RH, Gallezot JD, Ding YS, Henry S, Potenza MN, Southwick SM, Krystal JH, Carson RE, Neumeister A. Association of Posttraumatic Stress Disorder With Reduced In Vivo Norepinephrine Transporter Availability in the Locus Coeruleus. JAMA Psychiatry 2013, 70: 1199-1205. PMID: 24048210, PMCID: PMC4026855, DOI: 10.1001/jamapsychiatry.2013.399.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderNorepinephrine transporter availabilityLocus coeruleusPTSD groupTransporter availabilityHC groupVeterans Affairs Medical CenterStress disorderPTSD symptomsClinician-Administered PTSD ScalePositron emission tomography studyEmission tomography studiesPositron emission tomographyAnxious arousal symptomsNoradrenergic dysfunctionMedical CenterStudy groupMAIN OUTCOMEPTSD symptom clustersPTSD ScaleHealthy adultsCoeruleusBrain regionsChronic stressEmission tomography
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