2024
Intensive longitudinal assessment following index trauma to predict development of PTSD using machine learning
Horwitz A, McCarthy K, House S, Beaudoin F, An X, Neylan T, Clifford G, Linnstaedt S, Germine L, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Swor R, Hudak L, Pascual J, Seamon M, Harris E, Pearson C, Peak D, Domeier R, Rathlev N, Sergot P, Sanchez L, Bruce S, Joormann J, Harte S, Koenen K, McLean S, Sen S. Intensive longitudinal assessment following index trauma to predict development of PTSD using machine learning. Journal Of Anxiety Disorders 2024, 104: 102876. PMID: 38723405, PMCID: PMC11215748, DOI: 10.1016/j.janxdis.2024.102876.Peer-Reviewed Original ResearchTraumatic exposureIntensive longitudinal assessmentDevelopment of PTSDTrauma-related symptomsExposure to traumaFollow-up careTrauma exposureIndex traumaEmergency carePTSDAssess symptomsLongitudinal assessmentAssessment protocolCareParticipantsSymptomsFollow-upInterventionMachine learning analysisTraumaRiskIndividualsWeeksLearning analysisNervousness
1995
Effects of tryptophan depletion on responses to yohimbine in healthy human subjects
Goddard A, Charney D, Germine M, Woods S, Heninger G, Krystal J, Goodman W, Price L. Effects of tryptophan depletion on responses to yohimbine in healthy human subjects. Biological Psychiatry 1995, 38: 74-85. PMID: 7578653, DOI: 10.1016/0006-3223(94)00223-p.Peer-Reviewed Original ResearchConceptsHealthy human subjectsTryptophan depletionAlpha-2 adrenergic antagonist yohimbinePlacebo-controlled challenge testHuman subjectsAntagonist yohimbineNeurotransmitter systemsSerotonin systemChallenge testPossible functional interactionBiochemical variablesWhole groupFeelings of nervousnessNE functionMarked increaseNorepinephrineConsiderable evidenceFear responsesSubjectsHuman anxietyNervousnessCombination testControl testsFunctional interactionUnique changes
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