2023
Converging Evidence from Rodent and Human Studies on the Role of Spironolactone as a Potential Pharmacotherapy for Alcohol Use Disorder
Farokhnia M, Rentsch C, Chuong V, McGinn M, Elvig S, Douglass E, Gonzalez L, Sanfilippo J, Marchette R, Tunstall B, Fiellin D, Koob G, Justice A, Leggio L, Vendruscolo L. Converging Evidence from Rodent and Human Studies on the Role of Spironolactone as a Potential Pharmacotherapy for Alcohol Use Disorder. Alcohol 2023, 109: 83-84. DOI: 10.1016/j.alcohol.2023.03.071.Peer-Reviewed Original ResearchRole of spironolactoneAlcohol use disorderPotential pharmacotherapyUse disordersHuman studiesPharmacotherapySpironolactone
2021
Attachment Style Moderates Polygenic Risk for Incident Posttraumatic Stress in U.S. Military Veterans: A 7-Year, Nationally Representative, Prospective Cohort Study
Tamman AJF, Wendt FR, Pathak GA, Krystal JH, Southwick SM, Sippel LM, Gelernter J, Polimanti R, Pietrzak RH. Attachment Style Moderates Polygenic Risk for Incident Posttraumatic Stress in U.S. Military Veterans: A 7-Year, Nationally Representative, Prospective Cohort Study. Biological Psychiatry 2021, 91: 637-646. PMID: 34955171, DOI: 10.1016/j.biopsych.2021.09.025.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAttachment styleU.S. military veteransIncident posttraumatic stress disorderSocial environmental factorsDevelopment of PTSDMilitary veteransInsecure attachment stylesSecure attachment stylePolygenic riskEffect of PRSLifetime trauma burdenPTSD preventionPosttraumatic stressPTSD developmentPTSD symptomsStress disorderPolygenic risk scoresHigh polygenic riskProspective designNationally RepresentativePotential pharmacotherapyMultivariate geneStyleVeterans
2018
Pharmacotherapy for Co-Occurring Alcohol Use Disorder and Post-Traumatic Stress Disorder: Targeting the Opioidergic, Noradrenergic, Serotonergic, and GABAergic/Glutamatergic Systems.
Verplaetse TL, McKee SA, Petrakis IL. Pharmacotherapy for Co-Occurring Alcohol Use Disorder and Post-Traumatic Stress Disorder: Targeting the Opioidergic, Noradrenergic, Serotonergic, and GABAergic/Glutamatergic Systems. Alcohol Research 2018, 39: 193-205. PMID: 31198658, PMCID: PMC6561397, DOI: 10.35946/arcr.v39.2.09.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderCo-occurring alcohol use disorderAlcohol use disorderComorbid alcohol use disorderStress disorderNeurobiological systemsMaintenance of AUDUse disordersPTSD symptom severityAlcohol-motivated behaviorsAlcohol use outcomesPharmacologic treatment strategiesBrain systemsTreatment of individualsCurrent medicationsComorbid populationGlutamatergic systemPotential pharmacotherapyPharmacologic interventionsUse outcomesTreatment outcomesTreatment strategiesSingular diagnosisDual diagnosisTreatment interventions
2004
The Selective α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 [N-[(3 R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide Hydrochloride] Enhances GABAergic Synaptic Activity in Brain Slices and Restores Auditory Gating Deficits in Anesthetized Rats
Hajós M, Hurst R, Hoffmann W, Krause M, Wall T, Higdon N, Groppi V. The Selective α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 [N-[(3 R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide Hydrochloride] Enhances GABAergic Synaptic Activity in Brain Slices and Restores Auditory Gating Deficits in Anesthetized Rats. Journal Of Pharmacology And Experimental Therapeutics 2004, 312: 1213-1222. PMID: 15523001, DOI: 10.1124/jpet.104.076968.Peer-Reviewed Original ResearchMeSH Keywordsalpha7 Nicotinic Acetylcholine ReceptorAnimalsBenzamidesBenzylidene CompoundsBridged Bicyclo CompoundsCells, CulturedElectroencephalographyEvoked Potentials, Auditorygamma-Aminobutyric AcidHippocampusIntralaminar Thalamic NucleiNicotinic AgonistsPyridinesRatsRats, Sprague-DawleyReceptors, NicotinicSynapsesConceptsGABAergic synaptic activityAgonist PNU-282987PNU-282987Auditory gatingAlpha7 nAChRsAnesthetized ratsSynaptic activityHomomeric alpha7 nicotinic acetylcholine receptorsChloral hydrate-anesthetized ratsAlpha7 nicotinic acetylcholine receptorCultured rat hippocampal neuronsHippocampal GABAergic neurotransmissionReticular thalamic neuronsTreatment of schizophreniaHippocampal CA3 regionNovel selective agonistAuditory-evoked potentialsAuditory gating deficitsRat hippocampal neuronsNicotinic acetylcholine receptorsHippocampal oscillatory activityWhole-cell currentsAntagonist methyllycaconitineGABAergic neurotransmissionPotential pharmacotherapy
2001
Psychopharmacological challenge studies in psychiatric research
D'Souza D, Krystal J. Psychopharmacological challenge studies in psychiatric research. International Review Of Psychiatry 2001, 13: 40-46. DOI: 10.1080/09540260123077.Peer-Reviewed Original Research
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