2012
Assessment of left ventricular 2D flow pathlines during early diastole using spatial modulation of magnetization with polarity alternating velocity encoding: A study in normal volunteers and canine animals with myocardial infarction
Zhang Z, Friedman D, Dione DP, Lin BA, Duncan JS, Sinusas AJ, Sampath S. Assessment of left ventricular 2D flow pathlines during early diastole using spatial modulation of magnetization with polarity alternating velocity encoding: A study in normal volunteers and canine animals with myocardial infarction. Magnetic Resonance In Medicine 2012, 70: 766-775. PMID: 23044637, PMCID: PMC3844046, DOI: 10.1002/mrm.24517.Peer-Reviewed Original Research
2009
Pancreatic perfusion of healthy individuals and type 1 diabetic patients as assessed by magnetic resonance perfusion imaging
Hirshberg B, Qiu M, Cali AM, Sherwin R, Constable T, Calle RA, Tal MG. Pancreatic perfusion of healthy individuals and type 1 diabetic patients as assessed by magnetic resonance perfusion imaging. Diabetologia 2009, 52: 1561. PMID: 19488737, DOI: 10.1007/s00125-009-1406-8.Peer-Reviewed Original ResearchConceptsType 1 diabetic patientsPancreatic blood flowDiabetic patientsBlood flowIslet massHealthy volunteersPancreatic perfusionArterial spin labeling magnetic resonanceTotal pancreatic blood flowPancreatic beta-cell massConclusions/interpretationOur dataAims/hypothesisLossBeta-cell massMagnetic resonance perfusionSignificant differencesHuman pancreatic isletsDiabetes mellitusVascularised organsIslet functionMurine modelClamp studiesNormal volunteersHealthy individualsPatientsControl tissues
2007
The effect of doxapram on brain imaging in patients with panic disorder
Garakani A, Buchsbaum MS, Newmark RE, Goodman C, Aaronson CJ, Martinez JM, Torosjan Y, Chu KW, Gorman JM. The effect of doxapram on brain imaging in patients with panic disorder. European Neuropsychopharmacology 2007, 17: 672-686. PMID: 17560768, PMCID: PMC2695988, DOI: 10.1016/j.euroneuro.2007.04.002.Peer-Reviewed Original ResearchConceptsPanic disorder patientsDisorder patientsPlacebo saline solutionEffects of doxapramNormal control subjectsHeart rate increasePositron emission tomographyGreater heart rate increasePlacebo dayControl subjectsRespiratory stimulantCingulate gyrusDoxapramNormal volunteersPatientsPanic patientsPanic attacksPanic disorderDoxapram hydrochlorideSeparate daysEmission tomographyInhibitory centersFunctional imagingAmygdala activityCounterbalanced order
2005
Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine
Roberts JD, Gennings C, Shih M. Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine. European Journal Of Pharmacology 2005, 530: 54-58. PMID: 16375890, DOI: 10.1016/j.ejphar.2005.11.036.Peer-Reviewed Original ResearchConceptsExperimental pain modelsAnalgesic interactionPain modelVisual analog scaleFinding of synergyAffective responsesAffective componentsAffective aspectsAnalgesic effectAnalog scaleExperimental painNormal volunteersCrossover designMorphinePainSensory responsesPlaceboThermal stimuliSignificant interactionTHCSignificant effectFuture studiesSubjectsAnalgesiaAnalgesicsImpact of Schizophrenia and Chronic Antipsychotic Treatment on [123I]CNS-1261 Binding to N-Methyl-D-Aspartate Receptors In Vivo
Bressan RA, Erlandsson K, Stone JM, Mulligan RS, Krystal JH, Ell PJ, Pilowsky LS. Impact of Schizophrenia and Chronic Antipsychotic Treatment on [123I]CNS-1261 Binding to N-Methyl-D-Aspartate Receptors In Vivo. Biological Psychiatry 2005, 58: 41-46. PMID: 15992521, DOI: 10.1016/j.biopsych.2005.03.016.Peer-Reviewed Original ResearchConceptsHealthy control subjectsTypical antipsychoticsControl subjectsN-methyl-D-aspartate receptor functionN-methyl-D-aspartate receptorsAntipsychotic drug discoveryChronic antipsychotic treatmentDrug-free patientsImpact of schizophreniaNMDA receptor activityHealthy normal volunteersClozapine treatmentAntipsychotic treatmentGlutamatergic systemPatient groupAntipsychotic drugsNonsignificant reductionNMDA receptorsNormal volunteersSchizophrenia patientsControl groupReceptor activityBrain regionsReceptor functionTomography radiotracerPulmonary vein imaging: comparison of 3D magnetic resonance angiography with 2D cine MRI for characterizing anatomy and size.
Syed MA, Peters DC, Rashid H, Arai AE. Pulmonary vein imaging: comparison of 3D magnetic resonance angiography with 2D cine MRI for characterizing anatomy and size. Journal Of Cardiovascular Magnetic Resonance 2005, 7: 355-60. PMID: 15881514, DOI: 10.1081/jcmr-200053458.Peer-Reviewed Original ResearchConceptsPulmonary vein ostial diametersMagnetic resonance angiographyPulmonary veinsCine CMROstial diameterNormal volunteersResonance angiographyAtrial fibrillation ablation proceduresAtrial fibrillation patientsPulmonary vein diameterCardiac magnetic resonanceCine cardiac magnetic resonanceThree-dimensional magnetic resonance angiographyContrast-enhanced 3D MRAFibrillation patientsAtrial fibrillationVein diameterAblation proceduresAnatomical depictionPatientsT scannerAngiographyCine MRICMRVein
2003
Reversibility of severe metabolic stress in stored platelets after in vitro plasma rescue or in vivo transfusion: restoration of secretory function and maintenance of platelet survival
Rinder HM, Snyder EL, Tracey JB, Dincecco D, Wang C, Baril L, Rinder CS, Smith BR. Reversibility of severe metabolic stress in stored platelets after in vitro plasma rescue or in vivo transfusion: restoration of secretory function and maintenance of platelet survival. Transfusion 2003, 43: 1230-1237. PMID: 12919425, DOI: 10.1046/j.1537-2995.2003.00484.x.Peer-Reviewed Original ResearchConceptsGlycoprotein IIb/IIIaAlpha-granule releaseAdverse metabolic conditionsIIb/IIIaPlatelet recoveryPlatelet concentratesMetabolic conditionsVivo platelet recoveryPlatelet secretory responseSevere metabolic stressOsmotic recoveryAgonist-induced bindingAutologous transfusionTransient derangementSecretory responseFunctional derangementFunctional abnormalitiesMembrane phosphatidylserine exposureMetabolic rescueNormal volunteersPlatelet survivalPosttransfusion recoveryPlatelet aggregationImproved functionSecretory function
2001
Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy
Lin A, Nguy C, Shic F, Ross B. Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy. Toxicology Letters 2001, 123: 169-177. PMID: 11641045, DOI: 10.1016/s0378-4274(01)00396-4.Peer-Reviewed Original ResearchConceptsIntact blood-brain barrierBlood-brain barrierProbable Alzheimer's diseaseMagnetic resonance spectroscopyHuman brainVivo magnetic resonance spectroscopyNeurochemical effectsNormal subjectsNormal volunteersWhite matterAlzheimer's diseaseMethylsulfonylmethaneMemory lossPatientsToxic exposureBrainMedical benefitsResonance spectroscopySubjectsDiseaseDiagnosisDosesDailyVolunteersQuantification of BK1-5, the Stable Bradykinin Plasma Metabolite in Humans, by a Highly Accurate Liquid-Chromatographic Tandem Mass Spectrometric Assay
Murphey L, Hachey D, Vaughan D, Brown N, Morrow J. Quantification of BK1-5, the Stable Bradykinin Plasma Metabolite in Humans, by a Highly Accurate Liquid-Chromatographic Tandem Mass Spectrometric Assay. Analytical Biochemistry 2001, 292: 87-93. PMID: 11319821, DOI: 10.1006/abio.2001.5073.Peer-Reviewed Original Research
1999
Normal CSF oxytocin and NPY levels in OCD
Altemus M, Jacobson K, Debellis M, Kling M, Pigott T, Murphy D, Gold P. Normal CSF oxytocin and NPY levels in OCD. Biological Psychiatry 1999, 45: 931-933. PMID: 10202583, DOI: 10.1016/s0006-3223(98)00263-7.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderNPY levelsCSF levelsOCD patientsCSF oxytocinCentral nervous system neuropeptidesIncreased CSF levelsHealthy normal volunteersControl subjectsNPY regulationNormal volunteersHigher CSFSymptom profilesControl groupPatientsPotential mediatorsNeuropeptidesOxytocinSignificant differencesNPYCSFLevelsPrior findingsAbnormalities
1997
Quantification of Neuroreceptors in the Living Human Brain: IV. Effect of Aging and Elevations of D2-Like Receptors in Schizophrenia and Bipolar Illness
Wong D, Pearlson G, Tune L, Young L, Meltzer C, Dannals R, Ravert H, Reith J, Kuhar M, Gjedde A. Quantification of Neuroreceptors in the Living Human Brain: IV. Effect of Aging and Elevations of D2-Like Receptors in Schizophrenia and Bipolar Illness. Cerebrovascular And Brain Metabolism Reviews 1997, 17: 331-342. PMID: 9119906, DOI: 10.1097/00004647-199703000-00010.Peer-Reviewed Original ResearchConceptsD2-like dopamine receptorsDrug-naive schizophrenic patientsDopamine receptorsSchizophrenic patientsIllness patientsPatient groupControl subjectsReceptor densityD2 dopamine receptor densityDrug-naive schizophreniaDopamine receptor densityLiving Human BrainBipolar affective illnessD2 dopamine receptorsQuantification of NeuroreceptorsPositron emission tomographyEffect of ageBrain uptakeAffective illnessBipolar illnessNonpsychotic patientsCaudate nucleusNormal controlsNormal volunteersPatientsMotion artifact in T2‐weighted fast spin‐echo images of the liver: Effect on image contrast and reduction of artifact using respiratory triggering in normal volunteers
Choe K, Smith R, Wilkens K, Constable R. Motion artifact in T2‐weighted fast spin‐echo images of the liver: Effect on image contrast and reduction of artifact using respiratory triggering in normal volunteers. Journal Of Magnetic Resonance Imaging 1997, 7: 298-302. PMID: 9090581, DOI: 10.1002/jmri.1880070207.Peer-Reviewed Original ResearchConceptsFast spin-echo imagesSpin-echo imagesMultiple small cystsT2-weighted sequencesSpin-echo T2-weighted sequencesPatient triggeringFast spin-echo T2-weighted sequencesT2-weighted fast spin-echo imagesHealthy volunteersSmall cystsNormal volunteersRespiratory motionLiverRespiratory cycleCystsVolunteersGallbladderSpleenRespiratory triggeringImproved visualizationMotion artifactsSD/NSignificant improvementFlow compensationIndividual cysts
1996
Quantitative blood flow measurements with cine phase-contrast MR imaging of subjects at rest and after exercise to assess peripheral vascular disease.
Pena C, McCauley T, Price T, Sumpio B, Gusberg R, Gore J. Quantitative blood flow measurements with cine phase-contrast MR imaging of subjects at rest and after exercise to assess peripheral vascular disease. American Journal Of Roentgenology 1996, 167: 153-7. PMID: 8659362, DOI: 10.2214/ajr.167.1.8659362.Peer-Reviewed Original ResearchConceptsPeripheral vascular diseaseAnkle-brachial indexAbnormal ankle-brachial indexVascular diseaseVolume blood flowBlood flow measurementsBlood flowCine phase-contrast MR imagingLarger patient groupsPhase-contrast MR imagingPlantar flexion exerciseOlder normal volunteersVolume blood flow measurementsPopliteal arteryPatient groupFlexion exerciseNormal volunteersPatientsTriphasic waveformQuantitative blood flow measurementsFlow increasesMR imagingDiseaseVolunteersSimilar age
1995
Nitroprusside Inhibition of Platelet Function Is Transient and Reversible by Catecholamine Priming
Harris S, Rinder C, Rinder H, Tracey J, Smith B, Hines R. Nitroprusside Inhibition of Platelet Function Is Transient and Reversible by Catecholamine Priming. Anesthesiology 1995, 83: 1145-1152.. PMID: 8533905, DOI: 10.1097/00000542-199512000-00003.Peer-Reviewed Original ResearchConceptsAlpha-granule releaseSodium nitroprusside infusionSodium nitroprussidePlatelet functionNitroprusside infusionPlatelet aggregationSodium nitroprusside administrationP-selectin expressionPlatelet-rich plasmaMeasures of plateletIntravenous crystalloidImpaired coagulationNitroprusside administrationAntiplatelet effectEpinephrine pretreatmentNormal volunteersVivo findingsHuman volunteersNitroprussideVivo inhibitionVitro inhibitionInhibitory effectSignificant inhibitionRapid reversibilityTime courseInterobserver agreement and predictive value of endoscopic findings for H. pylori and gastritis in normal volunteers
Laine L, Cohen H, Sloane R, Marin-Sorensen M, Weinstein W. Interobserver agreement and predictive value of endoscopic findings for H. pylori and gastritis in normal volunteers. Gastrointestinal Endoscopy 1995, 42: 420-423. PMID: 8566631, DOI: 10.1016/s0016-5107(95)70043-9.Peer-Reviewed Original ResearchConceptsAntral nodularityPositive predictive valueH. pyloriPredictive valueArea gastricaeEndoscopic findingsEndoscopic featuresInterobserver agreementDiagnostic valueH. pylori gastritisSpecific endoscopic featuresGastric bodyHistologic gastritisPylori gastritisBiopsy specimensHealthy subjectsGastritisNormal volunteersHelicobacter pyloriFull endoscopyPyloriNodularityReproducible findingsErythemaCingulate gyrus in schizophrenic patients and normal volunteers
Noga J, Aylward E, Barta P, Pearlson G. Cingulate gyrus in schizophrenic patients and normal volunteers. Psychiatry Research 1995, 61: 201-208. PMID: 8748465, DOI: 10.1016/0925-4927(95)02612-2.Peer-Reviewed Original ResearchConceptsSeverity of hallucinationsCingulate gyrusNormal volunteersMagnetic resonance imaging sectionsPosterior cingulate gyrusPatient groupSchizophrenic patientsBrain volumeParental socioeconomic statusCingulate regionsPatientsCingulate structuresSocioeconomic statusInverse correlationGyrusInterrater reliabilityBonferroni correctionSchizophreniaSeverityVolunteersHallucinationsImaging sectionsLateral asymmetryGroupCerebrospinal Fluid Biogenic Amines in Obsessive Compulsive Disorder, Tourette's Syndrome, and Healthy Controls
Leckman J, Goodman W, Anderson G, Riddle M, Chappell P, McSwiggan-Hardin M, McDougle C, Scahill L, Ort S, Pauls D, Cohen D, Price L. Cerebrospinal Fluid Biogenic Amines in Obsessive Compulsive Disorder, Tourette's Syndrome, and Healthy Controls. Neuropsychopharmacology 1995, 12: 73-86. PMID: 7766289, DOI: 10.1038/sj.npp.1380241.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderTourette syndromeHealthy controlsOCD patientsTS patientsHomovanillic acidCerebrospinal fluidCerebrospinal fluid biogenic aminesMedication-free OCD patientsPathobiology of TSCSF HVA levelsCompulsive disorderLumbar cerebrospinal fluidConcentrations of tyrosineHVA levelsCSF norepinephrineNoradrenergic mechanismsSerotonergic mechanismsCSF MHPGSerotonergic systemHealthy subjectsHealthy volunteersNormal volunteersPatientsSyndromeCerebrospinal fluid biogenic amines in obsessive compulsive disorder, tourette's syndrome, and healthy controls
Leckman J, Goodman W, Anderson G, Riddle M, Chappell P, McSwiggan-Hardin M, McDougle C, Scahill L, Ort S, Pauls D, Cohen D, Price L. Cerebrospinal fluid biogenic amines in obsessive compulsive disorder, tourette's syndrome, and healthy controls. Neuropsychopharmacology 1995, 12: 73-86. DOI: 10.1016/0893-133x(94)00070-g.Peer-Reviewed Original ResearchObsessive-compulsive disorderTourette syndromeHealthy controlsOCD patientsTS patientsHomovanillic acidCerebrospinal fluidCerebrospinal fluid biogenic aminesMedication-free OCD patientsPathobiology of TSCSF HVA levelsCompulsive disorderLumbar cerebrospinal fluidConcentrations of tyrosineHVA levelsCSF norepinephrineNoradrenergic mechanismsSerotonergic mechanismsCSF MHPGSerotonergic systemHealthy subjectsHealthy volunteersNormal volunteersPatientsSyndrome913-117 Tc99m-Furifosmin Organ Clearance and Heart/Organ Ratio After Exercise and at Rest: Implication for Timing of Imaging
Daher E, Sinusas A, Wackers F, Natale D, Bruni W, Investigators T. 913-117 Tc99m-Furifosmin Organ Clearance and Heart/Organ Ratio After Exercise and at Rest: Implication for Timing of Imaging. Journal Of The American College Of Cardiology 1995, 25: 69a. DOI: 10.1016/0735-1097(95)91739-k.Peer-Reviewed Original ResearchSymptom overlap between OCD and bulimia nervosa
Rubenstein C, Altemus M, Pigott T, Hess A, Murphy D. Symptom overlap between OCD and bulimia nervosa. Journal Of Anxiety Disorders 1995, 9: 1-9. DOI: 10.1016/0887-6185(95)91551-r.Peer-Reviewed Original ResearchObsessive-compulsive disorderBulimic patientsOCD patientsNormal volunteersBulimia nervosaFemale bulimia nervosa patientsSCL-90Hamilton Depression Rating ScoreDepression rating scoresEffective nonpharmacological treatmentBulimia nervosa patientsInpatient treatment programFemale OCD patientsMeasures of depressionNonpharmacological treatmentsNormal womenNervosa patientsNormal controlsDepression subscalePsychiatric disordersPatientsSymptom overlapTreatment programSignificant decreaseBulimia subscale
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply