2025
Preliminary Evidence for Perturbation‐Based tACS‐EEG Biomarkers of Gamma Activity in Alzheimer's Disease
Palmisano A, Pezanko L, Cappon D, Tatti E, Macone J, Koch G, Smeralda C, Romanella S, Ruffini G, Rivolta D, Press D, Pascual‐Leone A, El‐Fakhri G, Santarnecchi E. Preliminary Evidence for Perturbation‐Based tACS‐EEG Biomarkers of Gamma Activity in Alzheimer's Disease. International Journal Of Geriatric Psychiatry 2025, 40: e70025. PMID: 39799469, DOI: 10.1002/gps.70025.Peer-Reviewed Original ResearchConceptsPeripheral neuroinflammationIdentification of novel biomarkersResponse to TACPatient's clinical phenotypeSpectral powerGABAergic dysfunctionNo significant correlationPrognostic valueInhibitory circuitryClinical severityClinical phenotypeAnimal modelsCognitive statusNeuroinflammatory markersAlzheimer's diseaseHuman patientsNeuroinflammatory biomarkersNovel biomarkersPatientsDisease severityTherapeutic targetGamma activityBiomarkersMild to moderate dementiaSignificant correlation
2024
Feedback System Analysis of a Multicomponent Intervention on Dyads of Home-Dwelling Persons With Dementia and Their Caregivers: Results From the LIVE@Home.Path Trial
Vislapuu M, Patrascu M, Allore H, Husebo B, Kjerstad E, Gedde M, Berge L. Feedback System Analysis of a Multicomponent Intervention on Dyads of Home-Dwelling Persons With Dementia and Their Caregivers: Results From the LIVE@Home.Path Trial. Innovation In Aging 2024, 8: igae020. PMID: 38550899, PMCID: PMC10976912, DOI: 10.1093/geroni/igae020.Peer-Reviewed Original ResearchInformal care timeCare timeInformal caregiversCaregiving experienceMulticomponent interventionStepped-wedge randomized controlled trialMild to moderate dementiaDementia Care CoordinationHome-dwelling personsInformal caregivers' experiencesInformal caregiver supportComplex intervention studiesDementia careRandomized Controlled TrialsCare coordinationCaregiving situationCaregiver supportSymptom managementGlobal Impression of ChangeClinical Global Impression of ChangeCare situationsModerate dementiaHealth servicesCare burdenImpression of ChangeA pilot study to evaluate the effect of CT1812 treatment on synaptic density and other biomarkers in Alzheimer’s disease
van Dyck C, Mecca A, O’Dell R, Bartlett H, Diepenbrock N, Huang Y, Hamby M, Grundman M, Catalano S, Caggiano A, Carson R. A pilot study to evaluate the effect of CT1812 treatment on synaptic density and other biomarkers in Alzheimer’s disease. Alzheimer's Research & Therapy 2024, 16: 20. PMID: 38273408, PMCID: PMC10809445, DOI: 10.1186/s13195-024-01382-2.Peer-Reviewed Original ResearchConceptsMild to moderate dementiaPositron emission tomographyAlzheimer's diseaseVolumetric MRIModerate dementiaClinical rating scalesSynaptic vesicle glycoprotein 2ACerebrospinal fluidMouse model of ADPharmacodynamic effectsPlacebo-controlled phase 1 clinical trialBiomarkers of AD pathologyClinical trialsCognitive measuresNominally significant differencesPhase 1 clinical trialModel of ADHippocampal cortexPhase 1/2 studyRating ScaleParallel-group trialSynaptic densityTrial registrationThe clinical trialPlacebo-ControlledSigma-2 receptor ligands
2023
FC46: The effectiveness of a multicomponent intervention on caregiver burden and informal care time in home-dwelling people with dementia and their caregivers. Results from the stepped wedge randomized controlled LIVE@Home.Path tria
Berge L, Angeles R, Allore H, Vislapuu M, Gedde M, Puaschitz N, Ballard C, Aarsland D, Selbæk G, Vahia I, Tzoulis C, Nouchi R, Husebo B. FC46: The effectiveness of a multicomponent intervention on caregiver burden and informal care time in home-dwelling people with dementia and their caregivers. Results from the stepped wedge randomized controlled LIVE@Home.Path tria. International Psychogeriatrics 2023, 35: 107-108. DOI: 10.1017/s1041610223001448.Peer-Reviewed Original ResearchRelative Stress ScaleHome-dwelling peopleIntervention periodCare timeCaregiver burdenPersonal activities of daily livingStepped-wedge randomized controlled trialMild to moderate dementiaActivities of daily livingDementia (RUDInformal caregiver burdenInformal care timeActive intervention periodMixed-effects regression modelsIntention-to-treat analysisRandomized Controlled TrialsInformal caregiversNursing careLiving interventionsMulticomponent interventionGlobal Impression of ChangeClinical Global Impression of ChangeModerate dementiaDaily livingHomecare services
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