2025
Gamma activation spread reflects disease activity in amyotrophic lateral sclerosis
Trubshaw M, Yoganathan K, Gohil C, Stagg C, Nobre A, Talbot K, Woolrich M, Thompson A, Turner M. Gamma activation spread reflects disease activity in amyotrophic lateral sclerosis. Clinical Neurophysiology 2025, 177: 2110823. PMID: 40610342, DOI: 10.1016/j.clinph.2025.2110823.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisDisease activityRegional spreadNeuronal oscillatory activityGamma activityHigher disease progression rateGamma frequency activityIsometric hand-grip exerciseNon-invasive measurementAmyotrophic lateral sclerosis groupHand-grip exerciseDisease progression rateLateral sclerosisMotor sub-scoresHealthy controlsMotor system dysfunctionSystem dysfunctionGrip strengthProgression rateFrequency activityOscillatory activityGrip exerciseSub-scoresSclerosisDiseasePreliminary Evidence for Perturbation‐Based tACS‐EEG Biomarkers of Gamma Activity in Alzheimer's Disease
Palmisano A, Pezanko L, Cappon D, Tatti E, Macone J, Koch G, Smeralda C, Romanella S, Ruffini G, Rivolta D, Press D, Pascual‐Leone A, El‐Fakhri G, Santarnecchi E. Preliminary Evidence for Perturbation‐Based tACS‐EEG Biomarkers of Gamma Activity in Alzheimer's Disease. International Journal Of Geriatric Psychiatry 2025, 40: e70025. PMID: 39799469, DOI: 10.1002/gps.70025.Peer-Reviewed Original ResearchConceptsPeripheral neuroinflammationIdentification of novel biomarkersResponse to TACPatient's clinical phenotypeSpectral powerGABAergic dysfunctionNo significant correlationPrognostic valueInhibitory circuitryClinical severityClinical phenotypeAnimal modelsCognitive statusNeuroinflammatory markersAlzheimer's diseaseHuman patientsNeuroinflammatory biomarkersNovel biomarkersPatientsDisease severityTherapeutic targetGamma activityBiomarkersMild to moderate dementiaSignificant correlation
2024
Parsing evoked and induced gamma response differences in Autism: A visual evoked potential study
Dickinson A, Ryan D, McNaughton G, Levin A, Naples A, Borland H, Bernier R, Chawarska K, Dawson G, Dziura J, Faja S, Kleinhans N, Sugar C, Senturk D, Shic F, Webb S, McPartland J, Jeste S, Trials F. Parsing evoked and induced gamma response differences in Autism: A visual evoked potential study. Clinical Neurophysiology 2024, 165: 55-63. PMID: 38959536, PMCID: PMC11684857, DOI: 10.1016/j.clinph.2024.05.015.Peer-Reviewed Original ResearchVisual evoked potentialsMeasurement of visual evoked potentialsGamma powerVisual evoked potential studiesABC-CTGamma responseAutism Biomarkers ConsortiumAbsence of significant group differencesChildren Aged 6Group differencesNon-phase-lockedEvoked PotentialsVEP componentsVEP dataAged 6Biomarkers ConsortiumNeural circuit dynamicsGamma activitySignificant group differencesIndividual markersTargeted approachWavelet-based time-frequency analysisInduced responsesChildrenInduced gamma
2023
Developmental changes in endogenous testosterone have sexually‐dimorphic effects on spontaneous cortical dynamics
Picci G, Ott L, Penhale S, Taylor B, Johnson H, Willett M, Okelberry H, Wang Y, Calhoun V, Stephen J, Wilson T. Developmental changes in endogenous testosterone have sexually‐dimorphic effects on spontaneous cortical dynamics. Human Brain Mapping 2023, 44: 6043-6054. PMID: 37811842, PMCID: PMC10619376, DOI: 10.1002/hbm.26496.Peer-Reviewed Original ResearchConceptsCortical activityRobust sex differencesFunctional brain developmentTypically-developing youthSpontaneous cortical activityLowest relative powerCortical dynamicsEndogenous testosteronePrefrontal cortexExecutive functionFrontal cortexPubertal hormonesNeural circuitryResting-stateStructural MRIEffects of testosteroneSex differencesEffects of endogenous testosteroneDevelopmental changesBrain developmentReverse patternBehavioral changesGamma activityDevelopmental windowDevelopmental patterns
2018
Neurophysiological correlates of holistic face processing in adolescents with and without autism spectrum disorder
Naumann S, Senftleben U, Santhosh M, McPartland J, Webb SJ. Neurophysiological correlates of holistic face processing in adolescents with and without autism spectrum disorder. Journal Of Neurodevelopmental Disorders 2018, 10: 27. PMID: 30165814, PMCID: PMC6118009, DOI: 10.1186/s11689-018-9244-y.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderMooney stimuliHolistic processingHolistic faceSpectrum disorderIQ-matched neurotypical controlsFace processing strategiesGamma-band activitySlow response timeMooney imagesFace processingASD engageASD groupERP componentsElectroencephalography (EEG) correlatesNeurophysiological correlatesNeurotypical controlsTemporal processingEarly processingP1 amplitudeNeural systemsProcessing strategiesGamma activityStimuliP1 latency
2017
The Cumulative Effects of Predictability on Synaptic Gain in the Auditory Processing Stream
Auksztulewicz R, Barascud N, Cooray G, Nobre A, Chait M, Friston K. The Cumulative Effects of Predictability on Synaptic Gain in the Auditory Processing Stream. Journal Of Neuroscience 2017, 37: 6751-6760. PMID: 28607165, PMCID: PMC5508257, DOI: 10.1523/jneurosci.0291-17.2017.Peer-Reviewed Original ResearchConceptsMagnetic field amplitudeField amplitudeAuditory processing streamSynaptic gainHealthy human volunteersSustained effectCross-spectral densityDynamic causal modelingSlow modulationSynaptic efficacyNeural gain modulationSlow fluctuationsBrain activityModel-based parametersHuman volunteersAuditory cortexModulation of synaptic gainGain modulationGamma activityProcess streamsModulation of brain activityPredictability of stimuliInduced activationEffects of predictabilitySource-level analysis
2014
Resting GABA and glutamate concentrations do not predict visual gamma frequency or amplitude
Cousijn H, Haegens S, Wallis G, Near J, Stokes M, Harrison P, Nobre A. Resting GABA and glutamate concentrations do not predict visual gamma frequency or amplitude. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 9301-9306. PMID: 24927588, PMCID: PMC4078853, DOI: 10.1073/pnas.1321072111.Peer-Reviewed Original ResearchConceptsGamma peak frequencyHealthy volunteersGamma oscillationsVisual gamma activityBeamformer spatial filtering techniquesPeak frequencyCortical gamma oscillationsMagnetic resonance spectroscopyExcitatory pyramidal cellsGamma activityGamma-band oscillationsMagnetic resonance spectroscopy voxelGABAergic interneuronsMagnetic resonance spectroscopy measurementsGaussian fittingPyramidal cellsMagnetic resonance spectroscopy dataGABA levelsGamma frequenciesGABA concentrationsMeasurement of GABAGABAGlutamate concentrationOscillationsOccipital lobe
2010
Resting-state EEG gamma activity in children with Attention-Deficit/Hyperactivity Disorder
Barry R, Clarke A, Hajos M, McCarthy R, Selikowitz M, Dupuy F. Resting-state EEG gamma activity in children with Attention-Deficit/Hyperactivity Disorder. Clinical Neurophysiology 2010, 121: 1871-1877. PMID: 20483659, DOI: 10.1016/j.clinph.2010.04.022.Peer-Reviewed Original ResearchConceptsAD/HDAttention-deficit/hyperactivity disorderParent Rating ScaleHyperactivity disorderGamma activitySex-matched controlsResting-state studiesEyes-closed resting conditionGamma bandConners' Parent Rating ScaleEEG gamma activityResting-state EEGEEG deficitsAbsolute deltaEEG profileRating ScaleResting conditionTheta activityElevated levelsRelative power measuresBeta bandReduced alphaGamma powerCognitive processing problemsChildren
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply