2024
Evaluating the concordance between International Classification of Diseases, Tenth Revision Code and stroke severity as measured by the National Institutes of Health Stroke Scale
Taha M, Habib M, Lomachinsky V, Hadar P, Newhouse J, Schwamm L, Blacker D, Moura L. Evaluating the concordance between International Classification of Diseases, Tenth Revision Code and stroke severity as measured by the National Institutes of Health Stroke Scale. BMJ Neurology Open 2024, 6: e000831. PMID: 39363950, PMCID: PMC11448239, DOI: 10.1136/bmjno-2024-000831.Peer-Reviewed Original ResearchPaul Coverdell National Acute Stroke ProgramNational Institutes of Health Stroke ScaleInternational Classification of DiseasesClassification of diseasesHealth Stroke ScaleInternational ClassificationICD-10Acute ischaemic strokeStroke severityICD-10 diagnosis codesStroke ScaleNIHSS scoreMeasures of stroke severityMedicare claims dataIntraclass correlation coefficientNational Institutes of Health Stroke Scale scoreNational InstituteMedicaid Services guidelinesService guidelinesStroke ProgramClinical registryDiagnosis codesClaims dataSampled patientsExpert clinical evaluationCombining electronic health records data from a clinical research network with registry data to examine long-term outcomes of interventions and devices: an observational cohort study
Mao J, Matheny M, Smolderen K, Mena-Hurtado C, Sedrakyan A, Goodney P. Combining electronic health records data from a clinical research network with registry data to examine long-term outcomes of interventions and devices: an observational cohort study. BMJ Open 2024, 14: e085806. PMID: 39327057, PMCID: PMC11429269, DOI: 10.1136/bmjopen-2024-085806.Peer-Reviewed Original ResearchConceptsElectronic health recordsElectronic health record dataClinical Research NetworkAmputation-free survivalPeripheral vascular interventionsResearch NetworkINSIGHT Clinical Research NetworkNew York CityHealth record dataIncreased riskLong-term outcomes of interventionsSecondary outcome measuresOutcomes of interventionsIncreased risk of deathYork CityRisk of deathObservational cohort studyHealth recordsRegistry dataClinical registryVascular Quality Initiative registryCohort studyOutcome assessmentRecord dataLong-term outcomes
2021
Integration of Regional Hospitalizations, Registry and Vital Statistics Data for Development of a Single Statewide Ischemic Stroke Database
Yan Z, Nielsen V, Song G, Christie A, Schwamm L, Zachrison K. Integration of Regional Hospitalizations, Registry and Vital Statistics Data for Development of a Single Statewide Ischemic Stroke Database. Journal Of Stroke And Cerebrovascular Diseases 2021, 31: 106236. PMID: 34954597, DOI: 10.1016/j.jstrokecerebrovasdis.2021.106236.Peer-Reviewed Original ResearchConceptsStroke databaseDetailed clinical variablesPopulation-based studyLong-term outcomesIndirect identifiersVital statistics databaseHospitalization registryStroke admissionsHospitalization databaseVital statistics dataTerm outcomesVital statusClinical variablesLarge-scale outcome researchClinical registryHospitalization recordsPatient variablesAdministrative databasesClinical dataRich clinical dataRegistryHospitalizationDeterministic linkageCumulative mortalityVital recordsHematopoietic cell transplantation for sickle cell disease: updates and future directions
Krishnamurti L. Hematopoietic cell transplantation for sickle cell disease: updates and future directions. Hematology 2021, 2021: 181-189. PMID: 34889368, PMCID: PMC8791142, DOI: 10.1182/hematology.2021000251.Peer-Reviewed Original ResearchConceptsHematopoietic cell transplantationSickle cell diseaseCell transplantationAlternative donorsCell diseaseOutcomes of HCTHLA-identical related donorsSymptomatic sickle cell diseaseNew disease-modifying drugsHost disease (GVHD) prophylaxisHLA-identical siblingsAvailable therapeutic optionsDisease-modifying drugsLong-term outcomesCord blood expansionConditioning regimensDisease prophylaxisRelated donorsOrgan damageHematopoietic progenitor cellsTherapeutic optionsExcellent outcomesCareful counselingAutologous transplantationClinical registryFrequency, Characteristics, and Outcomes of Endovascular Thrombectomy in Patients With Stroke Beyond 6 Hours of Onset in US Clinical Practice
Zachrison K, Schwamm L, Xu H, Matsouaka R, Shah S, Smith E, Xian Y, Fonarow G, Saver J. Frequency, Characteristics, and Outcomes of Endovascular Thrombectomy in Patients With Stroke Beyond 6 Hours of Onset in US Clinical Practice. Stroke 2021, 52: 3805-3814. PMID: 34470490, DOI: 10.1161/strokeaha.121.034069.Peer-Reviewed Original ResearchConceptsAcute ischemic stroke patientsEndovascular thrombectomyIschemic stroke patientsStroke patientsEVT casesGuidelines-Stroke hospitalsUS clinical practiceLower stroke severityClinical practice settingEVT outcomesEVT timesHospital mortalityNontrial settingDischarge dispositionIschemic strokePatient characteristicsStroke severityAtrial fibrillationFunctional outcomeClinical registryHospital characteristicsPatientsClinical practicePractice settingsStudy period
2018
Quality of care for ischemic stroke in China vs India: Findings from national clinical registries.
Li Z, Pandian J, Sylaja P, Wang Y, Zhao X, Liu L, Wang C, Khurana D, Srivastava M, Kaul S, Arora D, Schwamm L, Wang Y, Singhal A. Quality of care for ischemic stroke in China vs India: Findings from national clinical registries. Neurology 2018, 91: e1348-e1354. PMID: 30158158, PMCID: PMC6177271, DOI: 10.1212/wnl.0000000000006291.Peer-Reviewed Original ResearchConceptsChina National Stroke Registry IIGreater stroke severityStroke risk factorsRisk factorsStroke severityClinical outcomesStroke careIndian patientsAcademic stroke centerNational clinical registryIschemic stroke patientsBurden of strokeIschemic stroke careDifferent risk factorsQuality of careHospital mortalityIschemic strokeStroke centersAcute managementStroke patientsStroke ProjectChinese patientsClinical registryWorse outcomesAcademic hospital
2017
Unexplained Variation for Hospitals’ Use of Inpatient Rehabilitation and Skilled Nursing Facilities After an Acute Ischemic Stroke
Xian Y, Thomas L, Liang L, Federspiel J, Webb L, Bushnell C, Duncan P, Schwamm L, Stein J, Fonarow G, Hoenig H, Montalvo C, George M, Lutz B, Peterson E, Bettger J. Unexplained Variation for Hospitals’ Use of Inpatient Rehabilitation and Skilled Nursing Facilities After an Acute Ischemic Stroke. Stroke 2017, 48: 2836-2842. PMID: 28830975, DOI: 10.1161/strokeaha.117.016904.Peer-Reviewed Original ResearchConceptsInpatient rehabilitation facilitySkilled nursing facilitiesAcute ischemic strokeHospital-level variationIschemic strokeNursing facilitiesGuidelines-Stroke hospitalsMultilevel logistic regression modelsMedian odds ratioGeographic availabilityLogistic regression modelsIRF patientsHospital complicationsSNF patientsClinical characteristicsComorbid conditionsInpatient rehabilitationHospital characteristicsClinical registryOdds ratioRehabilitation facilityHospital useMedicare beneficiariesPatientsHospital
2015
Variation and Trends in the Documentation of National Institutes of Health Stroke Scale in GWTG-Stroke Hospitals
Reeves M, Smith E, Fonarow G, Zhao X, Thompson M, Peterson E, Schwamm L, Olson D. Variation and Trends in the Documentation of National Institutes of Health Stroke Scale in GWTG-Stroke Hospitals. Circulation Cardiovascular Quality And Outcomes 2015, 8: s90-8. PMID: 26515215, DOI: 10.1161/circoutcomes.115.001775.Peer-Reviewed Original ResearchConceptsGWTG-Stroke hospitalsHealth Stroke ScaleNIHSS scoreDocumentation ratesNIHSS dataStroke ScaleMultivariable logistic regression modelAcute ischemic strokeHospital-level factorsPrimary stroke centerImportant prognostic variablesPatient-level predictorsNational InstituteLogistic regression modelsMedian NIHSSIschemic strokeStroke centersThrombolysis candidatesClinical registryPrognostic variablesNIHSSHospitalPatientsStrokeLow documentationObesity in Youth with Type 1 Diabetes in Germany, Austria, and the United States
DuBose SN, Hermann JM, Tamborlane WV, Beck RW, Dost A, DiMeglio LA, Schwab KO, Holl RW, Hofer SE, Maahs DM, Willi S, Lipman T, Calvano T, Kucheruk O, Minnock P, Nguyen C, Klingensmith G, Banion C, Barker J, Cain C, Chase P, Hoops S, Kelsy M, Klingensmith G, Maahs D, Mowry C, Nadeau K, Raymond J, Rewers M, Rewers A, Slover R, Steck A, Wadwa P, Walravens P, Zeitler P, Haro H, Manseau K, Weinstock R, Izquierdo R, Sheikh U, Conboy P, Bulger J, Bzdick S, Goland R, Gandica R, Weiner L, Cook S, Greenberg E, Kohm K, Pollack S, Lee J, Gregg B, Tan M, Burgh K, Eason A, Garg S, Michels A, Myers L, DiMeglio L, Hannon T, Orr D, Cruz C, Woerner S, Wolfsdorf J, Quinn M, Tawa O, Ahmann A, Castle J, Joarder F, Bogan C, Cady N, Cox J, Pitts A, Fitch R, White B, Wollam B, Bode B, Lindmark K, Hosey R, Bethin K, Quattrin T, Ecker M, Wood J, Chao L, Cheung C, Fisher L, Jeandron D, Kaufman F, Kim M, Miyazaki B, Monzavi R, Patel P, Pitukcheewanont P, Sandstrom A, Cohen M, Ichihara B, Lipton M, Cemeroglu A, Appiagyei-Dankah Y, Daniel M, Postellon D, Racine M, Wood M, Kleis L, Hirsch I, DeSantis A, Dugdale D, Failor R, Gilliam L, Greenbaum C, Janci M, Odegard P, Trence D, Wisse B, Batts E, Dove A, Hefty D, Khakpour D, Klein J, Kuhns K, McCulloch-Olson M, Peterson C, Ramey M, St. Marie M, Thomson P, Webber C, Liljenquist D, Sulik M, Vance C, Coughenour T, Brown C, Halford J, Prudent A, Rigby S, Robison B, Starkman H, Berry T, Cerame B, Chin D, Ebner-Lyon L, Guevarra F, Sabanosh K, Silverman L, Wagner C, Fox M, Buckingham B, Shah A, Caswell K, Harris B, Bergenstal R, Criego A, Damberg G, Matfin G, Powers M, Tridgell D, Burt C, Olson B, Thomas L, Mehta S, Katz M, Laffel L, Hathway J, Phillips R, Cengiz E, Tamborlane W, Cappiello D, Steffen A, Zgorski M, Peters A, Ruelas V, Benjamin R, Adkins D, Cuffee J, Spruill A, Bergenstal R, Criego A, Damberg G, Matfin G, Powers M, Tridgell D, Burt C, Olson B, Thomas J, Aleppo-Kacmarek G, Derby T, Massaro E, Webb K, Solorzano C, DeBoer M, Madison H, McGill J, Buechler L, Clifton M, Hurst S, Kissel S, Recklein C, Tsalikian E, Tansey M, Cabbage J, Coffey J, Salamati S, Clements M, Raman S, Turpin A, Bedard J, Cohoon C, Elrod A, Fridlington A, Hester L, Kruger D, Schatz D, Clare-Salzler M, Cusi K, Digman C, Fudge B, Haller M, Meehan C, Rohrs H, Silverstein J, Wagh S, Cintron M, Sheehan E, Thomas J, Daniels M, Clark S, Flannery T, Forghani N, Naidu A, Reh C, Scoggin P, Trinh L, Ayala N, Quintana R, Speer H, Zipf W, Seiple D, Kittelsrud J, Gupta A, Peterson V, Stoker A, Gottschalk M, Hashiguchi M, Smith K, Rodriguez H, Bobik C, Henson D, Simmons J, Potter A, Black M, Brendle F, Gubitosi-Klug R, Kaminski B, Bergant S, Campbell W, Tasi C, Copeland K, Beck J, Less J, Schanuel J, Tolbert J, Adi S, Gerard-Gonzalez A, Gitelman S, Chettout N, Torok C, Pihoker C, Yi-Frazier J, Kearns S, Libman I, Bills V, Diaz A, Duke J, Nathan B, Moran A, Bellin M, Beasley S, Kogler A, Leschyshyn J, Schmid K, Street A, Nelson B, Frost C, Reifeis E, Haymond M, Bacha F, Caldas-Vasquez M, Klinepeter S, Redondo M, Berlanga R, Falk T, Garnes E, Gonzalez J, Martinez C, Pontifes M, Yulatic R, Arnold K, Evans T, Sellers S, Raman V, Foster C, Murray M, Raman V, Brown T, Slater H, Wheeler K, Harlan D, Lee M, Lock J, Hartigan C, Hubacz L, Buse J, Calikoglu A, Largay J, Young L, Brown H, Duncan V, Duclos M, Tricome J, Brandenburg V, Blehm J, Hallanger-Johnson J, Hanson D, Miller C, Weiss J, Hoffman R, Chaudhari M, Repaske D, Gilson E, Haines J, Rudolph J, McClave C, Biersdorf D, Tello A, Blehm J, Amundson D, Ward R, Rickels M, Dalton-Bakes C, Markman E, Peleckis A, Rosenfeld N, Dolan L, Corathers S, Kichler J, Baugh H, Standiford D, Hassing J, Jones J, Willis S, Willis S, Wysham C, Davis L, Blackman S, Abel K, Clark L, Jonas A, Kagan E, Sosenko J, Blashke C, Matheson D, Edelen R, Repas T, Baldwin D, Borgwardt T, Conroy C, DeGrote K, Marchiando R, Wasson M, Fox L, Mauras N, Damaso L, Englert K, Hamaty M, Kennedy L, Schweiger M, Konstantinopoulos P, Mawhorter C, Orasko A, Rose D, Deeb L, Rohrbacher K, Schroeder L, Roark A, Ali O, Kramer J, Whitson-Jones D, Potter A, Black M, Brendle F, Gassner H, Kollipara S, Bills V, Duke J, Harwood K, Prasad V, Brault J. Obesity in Youth with Type 1 Diabetes in Germany, Austria, and the United States. The Journal Of Pediatrics 2015, 167: 627-632.e4. PMID: 26164381, DOI: 10.1016/j.jpeds.2015.05.046.Peer-Reviewed Original ResearchConceptsBody mass index z-scoreProspective Follow-upType 1 diabetesSevere hypoglycemiaT1D ExchangeFollow-upGreater body mass index z-scoreOptimal glycemic controlIndex z-scoreMedian BMI valuesNational reference valuesGlycemic controlClinical registryGreater hemoglobinChildren 2BMI valuesBMI referencesAge groupsRegistryZ-scoreExcessive weightHypoglycemiaObesity problemObesityDiabetes
2014
Impact of timing on major complications after thoracic endovascular aortic repair for acute type B aortic dissection
Desai ND, Gottret JP, Szeto WY, McCarthy F, Moeller P, Menon R, Jackson B, Vallabhajosyula P, Wang GJ, Fairman R, Bavaria JE. Impact of timing on major complications after thoracic endovascular aortic repair for acute type B aortic dissection. Journal Of Thoracic And Cardiovascular Surgery 2014, 149: s151-s156. PMID: 25466855, DOI: 10.1016/j.jtcvs.2014.10.105.Peer-Reviewed Original ResearchConceptsType B dissectionEndovascular aortic repairB dissectionImpact of timingAortic repairAortic dissectionMedical therapyAcute type B aortic dissectionComplicated type B dissectionType B aortic dissectionB aortic dissectionHours of presentationOnset of symptomsRisk of complicationsWeeks of presentationOverall survivalSevere complicationsSurvival benefitMajor complicationsSuch patientsAcute patientsOpen surgeryRetrograde typeClinical registryTEVARInternational comparisons of the management of patients with non-ST segment elevation acute myocardial infarction in the United Kingdom, Sweden, and the United States: The MINAP/NICOR, SWEDEHEART/RIKS-HIA, and ACTION Registry-GWTG/NCDR registries
McNamara RL, Chung SC, Jernberg T, Holmes D, Roe M, Timmis A, James S, Deanfield J, Fonarow GC, Peterson ED, Jeppsson A, Hemingway H. International comparisons of the management of patients with non-ST segment elevation acute myocardial infarction in the United Kingdom, Sweden, and the United States: The MINAP/NICOR, SWEDEHEART/RIKS-HIA, and ACTION Registry-GWTG/NCDR registries. International Journal Of Cardiology 2014, 175: 240-247. PMID: 24882696, PMCID: PMC4112832, DOI: 10.1016/j.ijcard.2014.04.270.Peer-Reviewed Original ResearchConceptsNon-ST segment elevation myocardial infarctionPercutaneous coronary interventionManagement of patientsMyocardial infarctionRIKS-HIAAcute non-ST segment elevation myocardial infarctionNon-ST segment elevation acute myocardial infarctionEnzyme inhibitors/angiotensin receptor blockersSegment elevation acute myocardial infarctionElevation acute myocardial infarctionSegment elevation myocardial infarctionFuture comparative effectiveness researchAngiotensin receptor blockersPrior heart failureDual antiplatelet agentsElevation myocardial infarctionAcute myocardial infarctionComparative effectiveness researchCoronary interventionDischarge medicationsOngoing registryReceptor blockersHeart failureAntiplatelet agentsClinical registry
2012
Transthyretin Cardiac Amyloidoses in Older North Americans
Dharmarajan K, Maurer MS. Transthyretin Cardiac Amyloidoses in Older North Americans. Journal Of The American Geriatrics Society 2012, 60: 765-774. PMID: 22329529, PMCID: PMC3325376, DOI: 10.1111/j.1532-5415.2011.03868.x.Peer-Reviewed Original ResearchConceptsCardiac amyloidosesCardiac amyloidosisOlder personsSupportive medical careCongestive heart failureDisease-modifying agentsTTR cardiac amyloidosisConduction system diseaseSenile cardiac amyloidosisHeart failureUnderdiagnosed disorderAmyloid depositionRestrictive cardiomyopathyClinical registryDisease progressionCommon causeParkinson's diseaseSystem diseasesElderly adultsAlzheimer's diseaseMedical careExtracellular depositionDiseaseCardiac imagingAmyloidosis
2010
Implementation of a Registry for Acute Coronary Syndrome in Resource-Limited Settings: Barriers and Opportunities
Safavi K, Linnander EL, Allam AA, Bradley EH, Krumholz HM. Implementation of a Registry for Acute Coronary Syndrome in Resource-Limited Settings: Barriers and Opportunities. Asia Pacific Journal Of Public Health 2010, 22: 90s-95s. PMID: 20566539, DOI: 10.1177/1010539510373017.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeCardiovascular diseaseCoronary syndromeHealth systemClinical Outcomes RegistryEvidence-based careCause of deathResource limited settingsResource-limited settingsWorld health systemsQuality improvement activitiesMiddle-income countriesOutcomes RegistryHigh-quality treatmentBlame-free cultureClinical registryRegistrySyndromeImprovement activitiesHospitalDiseaseSetting
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