2025
Gene-dose effect of the glutathione biosynthesis gene on ascorbate deficiency in mice
Strand R, Orlicky D, Chen Y. Gene-dose effect of the glutathione biosynthesis gene on ascorbate deficiency in mice. Biochemical And Biophysical Research Communications 2025, 766: 151900. PMID: 40294460, PMCID: PMC12058385, DOI: 10.1016/j.bbrc.2025.151900.Peer-Reviewed Original ResearchConceptsGene-dose effectAscorbate deficiencyTissue GSH levelsDouble-knockoutVitamin CDietary vitamin CAllele dosage effectGlutamate-cysteine ligaseMiceClinical interplayGSH levelsOxidative stressBrain tissueRedox imbalanceGCLMDosage effectBrain functionDeficiencyGlutathione biosynthesis genesIncreased vulnerabilityBrainPhenotypic outcomesModifier subunitRedox balanceGSH biosynthesis
2023
Chapter 29 The aging eye and age-related ocular pathologies
Arat Y. Chapter 29 The aging eye and age-related ocular pathologies. 2023, 319-338. DOI: 10.1016/b978-0-323-98804-9.00001-3.Peer-Reviewed Original ResearchEye diseaseAge-related ocular pathologiesAge-related macular degenerationSight-threatening eye diseaseDry eye diseaseAge-related pathogenesisOcular surfaceMacular degenerationOcular pathologyAging eyeClinical findingsOphthalmic diseasesAge-relatedAge-related diseasesFunctional changesDiseaseEyesPathologyAgeGlaucomaIncreased vulnerabilityCataractPathogenesisRetinaLate life
2019
Poor Collaterals and Malignant CT Perfusion Profiles Are Associated with Increased Vulnerability to Blood Pressure Reductions during Endovascular Therapy (S57.002)
Strander S, Payabvash S, Wang A, Kodali S, Silverman A, Agarwal T, Stretz C, Zheng-Lin B, Cardenas G, Sansing L, Schindler J, Matouk C, Hebert R, Sheth K, Gutierrez S, Petersen N. Poor Collaterals and Malignant CT Perfusion Profiles Are Associated with Increased Vulnerability to Blood Pressure Reductions during Endovascular Therapy (S57.002). Neurology 2019, 92 DOI: 10.1212/wnl.92.15_supplement.s57.002.Peer-Reviewed Original Research
2001
Middle-Aged Men Show Higher Sensitivity of Sleep to the Arousing Effects of Corticotropin-Releasing Hormone Than Young Men: Clinical Implications
Vgontzas A, Bixler E, Wittman A, Zachman K, Lin H, Vela-Bueno A, Kales A, Chrousos G. Middle-Aged Men Show Higher Sensitivity of Sleep to the Arousing Effects of Corticotropin-Releasing Hormone Than Young Men: Clinical Implications. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 1489-1495. PMID: 11297573, DOI: 10.1210/jcem.86.4.7370.Peer-Reviewed Original ResearchConceptsHypothalamic-pituitary-adrenal axisSlow wave sleepMiddle-agedSuppression of slow wave sleepMiddle-aged menElevation of ACTHPrevalence of insomniaSleep disturbance effectsInhibiting slow wavesArousal effectHealthy middle-agedSleep onsetOvine CRHBaseline sleepStress hormonesClinical implicationsIncreased vulnerabilityYoung menEquipotent dosesHigher wakeBaseline nightSleep patternsSleepConsecutive nightsCRH
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