2025
FapR regulates HssRS-mediated heme homeostasis in Bacillus anthracis
Pi H, Burroughs O, Carlin S, Beavers W, Hillebrand G, Krystofiak E, Stauff D, Skaar E. FapR regulates HssRS-mediated heme homeostasis in Bacillus anthracis. MBio 2025, 16: e02057-24. PMID: 40407322, PMCID: PMC12153329, DOI: 10.1128/mbio.02057-24.Peer-Reviewed Original ResearchConceptsHeme homeostasisKnowledge of bacterial physiologyTwo-component signaling systemRegulation of fatty acid biosynthesisMembrane integrityFatty acid biosynthesisHeme toxicityCausative agent of anthraxHeme stressGram-positive pathogensAgent of anthraxGram-positive bacteriaBacterial physiologyHeme sensingTranscriptional regulationAcid biosynthesisTranscription factorsFapRFacultative anaerobesHeme biosynthesisRegulatory pathwaysHssRSVertebrate bloodMolecular adaptationsMolecular mechanisms
2024
Topical Clindamycin in the Management of Acne Vulgaris: Current Perspectives and Recent Therapeutic Advances.
Del Rosso J, Bunick C, Kircik L, Bhatia N. Topical Clindamycin in the Management of Acne Vulgaris: Current Perspectives and Recent Therapeutic Advances. Journal Of Drugs In Dermatology 2024, 23: 438-445. PMID: 38834223, DOI: 10.36849/jdd.8318.Peer-Reviewed Original ResearchConceptsAcne vulgarisTopical clindamycinTreatment of acne vulgarisManagement of acne vulgarisEmergence of antibiotic-resistant bacteriaAntibiotic-resistant bacteriaTopical agentsAnti-inflammatory propertiesTherapeutic advancesClindamycinClinical studiesTherapeutic outcomesClinical applicationAntimicrobial profileGram-positive bacteriaAnaerobic bacteriaMode of actionVulgarisMonotherapyPublished dataBacteriaTherapyAcneAntibiotics
2023
Evidence that OLE RNA is a component of a major stress‐responsive ribonucleoprotein particle in extremophilic bacteria
Breaker R, Harris K, Lyon S, Wencker F, Fernando C. Evidence that OLE RNA is a component of a major stress‐responsive ribonucleoprotein particle in extremophilic bacteria. Molecular Microbiology 2023, 120: 324-340. PMID: 37469248, DOI: 10.1111/mmi.15129.Peer-Reviewed Original ResearchConceptsOLE RNAPrecise biochemical functionFundamental cellular processesCell growthTOR complexesProtein partnersRibonucleoprotein complexesCellular processesRNP complexesBiochemical functionsGram-positive bacteriaNoncoding RNAsRibonucleoprotein particleExtremophilic bacteriaBacterial speciesGenetic disruptionStress conditionsDiverse pathwaysRNAMetabolic adaptationCell membraneExtreme environmentsCarbon sourceBacteriaComplexes
2021
Molecular Characterization of Antimicrobial Resistance and Virulence Genes of Bacterial Pathogens from Bovine and Caprine Mastitis in Northern Lebanon
Abboud Z, Galuppo L, Tolone M, Vitale M, Puleio R, Osman M, Loria G, Hamze M. Molecular Characterization of Antimicrobial Resistance and Virulence Genes of Bacterial Pathogens from Bovine and Caprine Mastitis in Northern Lebanon. Microorganisms 2021, 9: 1148. PMID: 34071800, PMCID: PMC8228836, DOI: 10.3390/microorganisms9061148.Peer-Reviewed Original ResearchMolecular characterizationMatrix-assisted laser desorptionGram-positive bacteriaResistance genesGenesPolymerase chain reactionPhylogenetic group B1Virulence factorsVirulence genesAntimicrobial resistance genesBacterial pathogensToxin genesLaser desorptionMastitis-causing pathogensNegative bacteriaBeta-lactamase genesFlight mass spectrometryBacterial identificationBacteriaQuadruplex PCR methodSymptoms of mastitisDairy animalsPhylogenetic typingIsolatesPathogens
2020
Lipoteichoic acid polymer length is determined by competition between free starter units
Hesser A, Schaefer K, Lee W, Walker S. Lipoteichoic acid polymer length is determined by competition between free starter units. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 29669-29676. PMID: 33172991, PMCID: PMC7703640, DOI: 10.1073/pnas.2008929117.Peer-Reviewed Original ResearchConceptsStarter unitGram-positive bacteriaLipoteichoic acidAlternative starter unitsLipoteichoic acid synthaseLipoteichoic acid polymersPolymer lengthCarbohydrate polymersAnionic glycopolymersDiglucosyl diacylglycerolLipid anchorAcid synthaseExtracellular leafletBiological functionsCell growthReconstituted systemBinding sitesLtaSPhosphatidylglycerolCell membraneStructural diversityBacteriaShort polymersPolymerEnzyme
2019
Telavancin-associated acute kidney injury.
Cavanaugh C, Moeckel GW, Perazella MA. Telavancin-associated acute kidney injury. Clinical Nephrology 2019, 91: 187-191. PMID: 30614441, DOI: 10.5414/cn109651.Peer-Reviewed Original ResearchConceptsAcute kidney injuryKidney injuryTubular injuryCases of AKIAcute interstitial nephritisProximal tubular injuryAcute tubular injuryHuman clinical trialsSelect infectionsInterstitial nephritisIntravenous therapyKidney biopsyKidney histopathologyHistologic changesClinical trialsHistopathologic descriptionAnimal modelsLysosomal proliferationTelavancinInjurySemi-synthetic derivativesNumerous phagolysosomesStaphylococciGram-positive bacteriaNephritis
2016
Biogenesis of the Gram-positive bacterial cell envelope
Siegel S, Liu J, Ton-That H. Biogenesis of the Gram-positive bacterial cell envelope. Current Opinion In Microbiology 2016, 34: 31-37. PMID: 27497053, PMCID: PMC5164837, DOI: 10.1016/j.mib.2016.07.015.Peer-Reviewed Original ResearchConceptsWall teichoic acidGram-positive cell envelopeCell envelopeLipoteichoic acidLytR-CpsA-Psr family proteinsPhylum of Gram-positive bacteriaSortase-assembled piliCell envelope biogenesisBacterial cell envelopeGram-negative counterpartsGram-positive bacterial cell envelopeGram-positive bacteriaEnvelope biogenesisFamily proteinsTeichoic acidGram-negative organismsSurface displaySurface proteinsFolding mechanismOxidized proteinsGram-positiveCapsular polysaccharideDivergent functionsPiliBiogenesis
2010
A Biosynthetic Strategy for Re-engineering the Staphylococcus aureus Cell Wall with Non-native Small Molecules
Nelson JW, Chamessian AG, McEnaney PJ, Murelli RP, Kazmiercak B, Spiegel DA. A Biosynthetic Strategy for Re-engineering the Staphylococcus aureus Cell Wall with Non-native Small Molecules. ACS Chemical Biology 2010, 5: 1147-1155. PMID: 20923200, PMCID: PMC3003768, DOI: 10.1021/cb100195d.Peer-Reviewed Original ResearchConceptsCell wallCell wall engineeringCell-wall peptidoglycanWild-type bacteriaGram-positive bacterial pathogensPathogenic Gram-positive bacteriaStaphylococcus aureus cell wallBacterial cell wallBacterial cell surfaceEnzyme sortase ASmall moleculesGram-positive bacteriaWall peptidoglycanAureus cell wallMolecular handleBiosynthetic strategiesCell surfaceBacterial pathogensEndogenous levelsSortase AAzide-alkyne cycloaddition reactionChemical handlesWall engineeringBacteriaWidespread utilityThe large, noncoding OLE RNA is associated with membrane biochemistry
Block K, Wallace J, Puerta‐Fernandez E, Breaker R. The large, noncoding OLE RNA is associated with membrane biochemistry. The FASEB Journal 2010, 24: 493.2-493.2. DOI: 10.1096/fasebj.24.1_supplement.493.2.Peer-Reviewed Original ResearchOLE RNAB. haloduransMembrane biochemistryMembrane-spanning proteinsHigh-throughput sequencingEnergy-generating pathwaysEscherichia coli cellsGel shift assaysNorthern blot analysisRNA fluorescenceSpecific ribonucleoproteinGram-positive bacteriaShift assaysColi cellsUnknown functionProbable binding siteSitu hybridizationBlot analysisBinding sitesHaloduransHoward Hughes Medical InstituteRNAProteinBiochemistryCells
2006
Phylogenetic diversity of culturable bacteria from alpine permafrost in the Tianshan Mountains, northwestern China
Bai Y, Yang D, Wang J, Xu S, Wang X, An L. Phylogenetic diversity of culturable bacteria from alpine permafrost in the Tianshan Mountains, northwestern China. Research In Microbiology 2006, 157: 741-751. PMID: 16690258, DOI: 10.1016/j.resmic.2006.03.006.Peer-Reviewed Original ResearchConceptsPhylogenetic diversityDiverse microbial lineagesEvolutionary distance matricesSpecific ecological nichesCulturable bacterial communityRDNA restriction analysisPermafrost sedimentsMicrobial lineagesCFB phylumGram-positiveCytophaga-FlavobacteriumGenus ChryseobacteriumEndospore formationPhylogenetic treeEcological nichesPhylogenetic analysisGram-positive bacteriaBacteroides phylumNew speciesBacterial communitiesARDRA patternsColony pigmentationCulturable populationsPhenotypic propertiesCulturable bacteria
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