2025
Modeling thoracic aortic genetic variants in the zebrafish: useful for predicting clinical pathogenicity?
Prendergast A, Sheppard M, Famulski J, Nicoli S, Mukherjee S, Sips P, Elefteriades J. Modeling thoracic aortic genetic variants in the zebrafish: useful for predicting clinical pathogenicity? Frontiers In Cardiovascular Medicine 2025, 12: 1480407. PMID: 40066353, PMCID: PMC11892108, DOI: 10.3389/fcvm.2025.1480407.Peer-Reviewed Original ResearchPathogenicity of VUSProportion of variantsMedical genetic testingCausal genesPathogenicity assessmentClinical pathogensTested pathogensGenetic variantsCausative genesTAAD casesGenesGenetic defectsGenetic testingThoracic aortic aneurysmHeritable genetic defectsImpact cardiovascular morbidityPathogensVUSAortic aneurysmCardiovascular morbidityVariantsZebrafishTAADClinical applicationEnhance patient care
2023
Digital assay for rapid electronic quantification of clinical pathogens using DNA nanoballs
Tayyab M, Barrett D, van Riel G, Liu S, Reinius B, Scharfe C, Griffin P, Steinmetz L, Javanmard M, Pelechano V. Digital assay for rapid electronic quantification of clinical pathogens using DNA nanoballs. Science Advances 2023, 9: eadi4997. PMID: 37672583, PMCID: PMC10482329, DOI: 10.1126/sciadv.adi4997.Peer-Reviewed Original ResearchConceptsMicrofluidic impedance cytometerDNA nanoballsLabel-free assayColorimetric readoutImpedance cytometerDigital assaysLoop-mediated isothermal amplificationCapillary-driven flowNanoballsDNA detectionStandalone deviceDNA/RNAIsothermal amplificationCompact systemNucleic acidsClinical pathogensPathogen identificationAccurate detectionRapid testReadoutDetectionNovel methodImpedance
2017
A Tick Antivirulence Protein Potentiates Antibiotics against Staphylococcus aureus
Abraham NM, Liu L, Jutras BL, Murfin K, Acar A, Yarovinsky TO, Sutton E, Heisig M, Jacobs-Wagner C, Fikrig E. A Tick Antivirulence Protein Potentiates Antibiotics against Staphylococcus aureus. Antimicrobial Agents And Chemotherapy 2017, 61: 10.1128/aac.00113-17. PMID: 28438938, PMCID: PMC5487661, DOI: 10.1128/aac.00113-17.Peer-Reviewed Original ResearchConceptsNovel alternative therapeutic strategyAlternative therapeutic strategiesEfficacy of antibioticsTherapeutic strategiesTransgenic miceBacterial infectionsInfection modelDifferent antibioticsAntibioticsAntibiotic resistanceStaphylococcus aureusPotency of antibioticsClinical pathogensPeptides representativeImproved permeationPathogensPotent antibiofilm propertiesIAFGP
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