2024
Direct cardiac reprogramming via combined CRISPRa-mediated endogenous Gata4 activation and exogenous Mef2c and Tbx5 expression
Huang P, Xu J, Keepers B, Xie Y, Near D, Xu Y, Hua J, Spurlock B, Ricketts S, Liu J, Wang L, Qian L. Direct cardiac reprogramming via combined CRISPRa-mediated endogenous Gata4 activation and exogenous Mef2c and Tbx5 expression. Molecular Therapy - Nucleic Acids 2024, 35: 102390. PMID: 39720701, PMCID: PMC11666955, DOI: 10.1016/j.omtn.2024.102390.Peer-Reviewed Original ResearchActivity of endogenous factorsDirect cardiac reprogrammingInduced cardiomyocytesCardiac reprogrammingExpression of cardiac transcription factorsCardiac transcription factorsTranscription factorsReprogramming of fibroblastsSingle-guide RNAViral toxicityViral vectorsExogenous transcription factorsImmune responseEpigenetic barriersGATA4 activityRegenerative purposesClinical applicationEndogenous factorsEndogenous transcription factorsGenomic mutationsExogenous expressionReprogrammingFibroblastsEndogenous gene expressionHuman fibroblasts
2020
Contributions of maternal and fetal antiviral immunity in congenital disease
Yockey LJ, Lucas C, Iwasaki A. Contributions of maternal and fetal antiviral immunity in congenital disease. Science 2020, 368: 608-612. PMID: 32381717, DOI: 10.1126/science.aaz1960.Peer-Reviewed Original ResearchConceptsViral infectionCongenital diseaseDirect viral toxicityMaternal immune responseMaternal immune activationFetal developmental defectsFuture treatment strategiesImmune defense mechanismsPregnancy outcomesFetal demiseImmune activationUncontrolled inflammationMaternal healthChronic infectionTreatment strategiesImmune responseAntiviral immunityRange of syndromesFetal developmentTissue damagePathological effectsInfectionViral toxicityDevastating consequencesPregnancy
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