2024
Direct cardiac reprogramming via combined CRISPRa-mediated endogenous Gata4 activation and exogenous Mef2c and Tbx5 expression
Huang P, Xu J, Keepers B, Xie Y, Near D, Xu Y, Hua J, Spurlock B, Ricketts S, Liu J, Wang L, Qian L. Direct cardiac reprogramming via combined CRISPRa-mediated endogenous Gata4 activation and exogenous Mef2c and Tbx5 expression. Molecular Therapy - Nucleic Acids 2024, 35: 102390. PMID: 39720701, PMCID: PMC11666955, DOI: 10.1016/j.omtn.2024.102390.Peer-Reviewed Original ResearchActivity of endogenous factorsDirect cardiac reprogrammingInduced cardiomyocytesCardiac reprogrammingExpression of cardiac transcription factorsCardiac transcription factorsTranscription factorsReprogramming of fibroblastsSingle-guide RNAViral toxicityViral vectorsExogenous transcription factorsImmune responseEpigenetic barriersGATA4 activityRegenerative purposesClinical applicationEndogenous factorsEndogenous transcription factorsGenomic mutationsExogenous expressionReprogrammingFibroblastsEndogenous gene expressionHuman fibroblasts
2023
Optimized protocol for direct cardiac reprogramming in mice using Ascl1 and Mef2c
Wang H, Keepers B, Liu J, Qian L. Optimized protocol for direct cardiac reprogramming in mice using Ascl1 and Mef2c. STAR Protocols 2023, 4: 102204. PMID: 36989109, PMCID: PMC10074248, DOI: 10.1016/j.xpro.2023.102204.Peer-Reviewed Original ResearchCardiac reprogrammingNeonatal mouse cardiac fibroblastsIntermediate progenitor stageDirect cardiac reprogrammingCardiomyocyte-like cellsMouse cardiac fibroblastsConversion of fibroblastsCalcium fluxReprogramming factorsProgenitor stageCardiac fibroblastsSarcomere structureAscl1MEF2CReprogrammingMiceGene expressionFibroblastsOptimized protocol
2020
An Optimized Protocol for Human Direct Cardiac Reprogramming
Garbutt T, Zhou Y, Keepers B, Liu J, Qian L. An Optimized Protocol for Human Direct Cardiac Reprogramming. STAR Protocols 2020, 1: 100010. PMID: 32728671, PMCID: PMC7390466, DOI: 10.1016/j.xpro.2019.100010.Peer-Reviewed Original Research
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