2024
Understanding nanoparticle-liver interactions in nanomedicine
He Y, Wang Y, Wang L, Jiang W, Wilhelm S. Understanding nanoparticle-liver interactions in nanomedicine. Expert Opinion On Drug Delivery 2024, 21: 829-843. PMID: 38946471, PMCID: PMC11281865, DOI: 10.1080/17425247.2024.2375400.Peer-Reviewed Original ResearchConceptsLiver Kupffer cellsNanoparticle physicochemical propertiesEnhanced delivery efficiencyAdministered nanoparticlesEffective nanomedicinesKupffer cellsLiver diseasePhagocytic functionClinical translationHepatic diseaseLiver accumulationClinical applicationNanomedicineDelivery efficiencyLiverPhagocytic roleDisease
2022
Transjugular Intrahepatic Portosystemic Shunt for Refractory Ascites in Gaucher Disease
Adhyaru K, Menezes S, Mistry PK, Nagral A, Mistry P. Transjugular Intrahepatic Portosystemic Shunt for Refractory Ascites in Gaucher Disease. Cureus 2022, 14: e23941. PMID: 35535294, PMCID: PMC9079779, DOI: 10.7759/cureus.23941.Peer-Reviewed Original ResearchHepatic venous pressure gradientGaucher diseaseRefractory ascitesTransjugular intrahepatic portosystemic shuntTransjugular intrahepatic portosystemic shunt (TIPS) procedureAdvanced hepatic diseaseVenous pressure gradientIntrahepatic portosystemic shuntAnterior abdominal wallPortosystemic shunt procedureEnzyme replacement therapyAvascular osteonecrosisLiver transplantationLysosomal storage disorderPortal hypertensionVariceal bleedingSevere cytopeniaHepatic encephalopathyVenous collateralsLiver diseaseShunt procedurePortosystemic shuntReplacement therapyHepatic diseaseAbdominal wall
2017
Tobacco and alcohol use disorders: Evaluating multimorbidity
MacLean RR, Sofuoglu M, Rosenheck R. Tobacco and alcohol use disorders: Evaluating multimorbidity. Addictive Behaviors 2017, 78: 59-66. PMID: 29127785, DOI: 10.1016/j.addbeh.2017.11.006.Peer-Reviewed Original ResearchConceptsTobacco use disorderAlcohol use disorderVeterans Health AdministrationUse disordersConcurrent alcohol use disorderMental health outpatient servicesMental health disordersCo-occurring diagnosesCo-occurring conditionsHepatic diseaseUse of substancesOutpatient servicesService usePsychiatric diagnosisTreatment approachesHealth disordersDisability pensionHealth AdministrationSocio-environmental factorsAdverse effectsDiagnosisDisordersGreater likelihoodVeteransHigh rateWilson Disease
Schilsky M, Ala A. Wilson Disease. 2017, 799-819. DOI: 10.1002/9781119251316.ch29.Peer-Reviewed Original ResearchWilson's diseaseExcellent patient survivalAcute liver failureCentral nervous systemAsymptomatic patientsBiliary copper excretionLiver transplantationPharmacologic treatmentSymptomatic patientsHepatic insufficiencyLiver failureMedical therapyLiver diseasePatient survivalHepatic diseasePsychiatric symptomsNervous systemBiochemical findingsCopper excretionDiseaseInherited disorderDisease-specific mutationsPatientsMutation analysisTreatmentClinical Epidemiology of Single Versus Multiple Substance Use Disorders
Bhalla IP, Stefanovics EA, Rosenheck RA. Clinical Epidemiology of Single Versus Multiple Substance Use Disorders. Medical Care 2017, 55: s24-s32. PMID: 28806363, DOI: 10.1097/mlr.0000000000000731.Peer-Reviewed Original ResearchConceptsSingle substance use disorderPolysubstance use disorderSubstance use disordersUse disordersNational Veterans Health Administration dataVeterans Health Administration dataMultiple logistic regression analysisMultiple substance use disordersPsychotropic medication prescriptionsHealth Administration dataPsychiatric inpatient careMajor depressive disorderPsychiatric service utilizationLogistic regression analysisMedical morbidityMedication prescriptionsPsychotropic medicationsFiscal year 2012Hepatic diseaseDepressive disorderInpatient careRehabilitative treatmentService utilizationClinical epidemiologyBipolar disorderNonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases
Samuel VT, Shulman GI. Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases. Cell Metabolism 2017, 27: 22-41. PMID: 28867301, PMCID: PMC5762395, DOI: 10.1016/j.cmet.2017.08.002.Peer-Reviewed Original ResearchConceptsInsulin resistanceNonalcoholic fatty liver diseaseFatty liver diseasePeripheral insulin resistanceHepatic insulin resistanceNew pharmacological strategiesHepatic complicationsBariatric surgeryLiver diseaseInsulin-stimulated glycogen synthesisHepatic diseasePharmacological strategiesNAFLDReceptor activationHepatic glucoseLipid metabolismInsulin receptor activationWeight lossEnergy expenditureHepatic diacylglycerolsGlycogen synthesisDiseaseLipid synthesisFlux of substratesComplications
2014
Bile Acid Nephropathy in a Bodybuilder Abusing an Anabolic Androgenic Steroid
Luciano RL, Castano E, Moeckel G, Perazella MA. Bile Acid Nephropathy in a Bodybuilder Abusing an Anabolic Androgenic Steroid. American Journal Of Kidney Diseases 2014, 64: 473-476. PMID: 24953892, DOI: 10.1053/j.ajkd.2014.05.010.Peer-Reviewed Case Reports and Technical NotesConceptsAcute kidney injurySevere cholestatic liver diseaseCholestatic liver diseaseLiver diseaseAcute tubular injury/necrosisCases of AKIEnd-stage liver diseaseBile acid injurySevere obstructive jaundiceAcute tubular injuryAnabolic androgenic steroidsAnabolic-androgenic steroid useCholemic nephrosisHepatorenal syndromeKidney injuryTubular injuryObstructive jaundiceHemodynamic changesTubular toxicitySteroid useAcid injuryHepatic diseaseTubular cellsHeterogeneous lesionsNephropathySystematic review of outcomes of patients undergoing resection for colorectal liver metastases in the setting of extra hepatic disease
Hwang M, Jayakrishnan T, Green D, George B, Thomas J, Groeschl R, Erickson B, Pappas S, Gamblin T, Turaga K. Systematic review of outcomes of patients undergoing resection for colorectal liver metastases in the setting of extra hepatic disease. European Journal Of Cancer 2014, 50: 1747-1757. PMID: 24767470, DOI: 10.1016/j.ejca.2014.03.277.Peer-Reviewed Original ResearchConceptsColorectal liver metastasesExtra-hepatic diseaseMedian survivalOverall survivalHepatic resectionLiver metastasesHepatic diseaseColorectal liver metastases patientsDistribution of metastatic diseaseOperative mortality rateSignificant survival benefitMinimal liver diseaseOutcomes of patientsPrimary outcome measureMetastatic diseaseSurgical resectionMultimodal therapySurvival benefitLymph nodesResectionLiver diseasePatientsPrimary exposureMeta-regression techniquesMortality rate
2010
Liver transplantation for inherited metabolic disorders of the liver
Moini M, Mistry P, Schilsky ML. Liver transplantation for inherited metabolic disorders of the liver. Current Opinion In Organ Transplantation 2010, 15: 269-276. PMID: 20489626, DOI: 10.1097/mot.0b013e3283399dbd.Peer-Reviewed Original ResearchConceptsLiver transplantExtrahepatic diseaseLiver transplantationGlycogen storage disease type ICareful patient selectionOutcome of transplantationImportant therapeutic modalityMultisystemic genetic disorderMajor hepatic diseasesUrea cycle defectsGene replacement therapyHepatic complicationsSurgical managementLiver replacementMetabolic managementPatient selectionPrimary hyperoxaluriaReplacement therapyHepatic diseaseImproved outcomesTherapeutic modalitiesMetabolic disordersMetabolic diseasesTransplantLiver results
2009
How Common Is Diclofenac-Associated Liver Injury? Analysis of 17,289 Arthritis Patients in a Long-Term Prospective Clinical Trial
Laine L, Goldkind L, Curtis SP, Connors LG, Yanqiong Z, Cannon CP. How Common Is Diclofenac-Associated Liver Injury? Analysis of 17,289 Arthritis Patients in a Long-Term Prospective Clinical Trial. The American Journal Of Gastroenterology 2009, 104: ajg2008149. PMID: 19174782, DOI: 10.1038/ajg.2008.149.Peer-Reviewed Original ResearchConceptsLiver-related hospitalizationsNon-steroidal anti-inflammatory drugsMonths of therapyAminotransferase elevationLiver eventsClinical trialsLong-term prospective clinical trialsLarge double-blind trialDeath/transplantHepatotoxicity of diclofenacTransplant/deathDouble-blind trialPrescribed non-steroidal anti-inflammatory drugsProspective clinical trialsAdverse hepatic effectsALT/ASTRates of laboratoryAnti-inflammatory drugsProspective trialArthritis patientsLiver injuryRheumatoid arthritisClinical eventsHepatic diseaseCausality assessment
2008
Delayed intravascular haemolysis following multiple asymptomatic ABO‐incompatible red blood cell transfusions in a patient with hepatic failure
Tormey CA, Stack G. Delayed intravascular haemolysis following multiple asymptomatic ABO‐incompatible red blood cell transfusions in a patient with hepatic failure. Vox Sanguinis 2008, 95: 232-235. PMID: 19121188, DOI: 10.1111/j.1423-0410.2008.01085.x.Peer-Reviewed Original ResearchConceptsABO-incompatible red blood cell (RBC) transfusionsRed blood cell transfusionBlood cell transfusionFresh frozen plasmaCell transfusionHepatic failureDelayed Haemolytic Transfusion ReactionAnamnestic antibody responseLow complement levelsHaemolytic transfusion reactionsOnset of haemolysisFirst transfusionRBC transfusionComplement levelsIncompatible transfusionsAntibody responseAntibody titresHepatic diseaseTransfusion reactionsIntravascular haemolysisTransfusionPatientsRBC unitsB RBCsHaemolysis
1994
Comparison of contrast enhanced CT and Mn-DPDP enhanced MRI for detection of focal hepatic lesions initial findings
Birnbaum B, Weinreb J, Fernandez M, Brown J, Rofsky N, Young S. Comparison of contrast enhanced CT and Mn-DPDP enhanced MRI for detection of focal hepatic lesions initial findings. Clinical Imaging 1994, 18: 21-27. PMID: 8180855, DOI: 10.1016/0899-7071(94)90141-4.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingMn-DPDPMore lesionsRetrospective multi-institutional studyExtensive metastatic diseaseHepatic magnetic resonance imagingMulti-institutional studyFocal hepatic diseaseFocal liver lesionsN'-dipyridoxylethylenediamineMetastatic diseaseIntravenous bolusDose groupFatty liverHepatic diseaseComparison of ContrastHepatic lesionsComputed tomographyLiver lesionsCT studiesPatientsMumol/Resonance imagingBolus contrastLesions
1992
Hepatic MR imaging with Mn-DPDP: safety, image quality, and sensitivity.
Bernardino M, Young S, Lee J, Weinreb J. Hepatic MR imaging with Mn-DPDP: safety, image quality, and sensitivity. Radiology 1992, 183: 53-8. PMID: 1549694, DOI: 10.1148/radiology.183.1.1549694.Peer-Reviewed Original ResearchConceptsMn-DPDPMore lesionsAdditional lesionsT1-weighted imagesDose groupSerious side effectsMagnetic resonance imagingT2-weighted imagesFocal hepatic diseaseN'-dipyridoxylethylenediamineIntravenous bolusHepatic diseaseMultiinstitutional studyPatientsSide effectsLesionsResonance imagingHepatic MRManganese NImaging parametersContrast agentsImagingGroupInfusionBolus
1991
Contrast-Enhanced Magnetic Resonance Imaging of the Liver with Mn-DPDP for Known or Suspected Focal Hepatic Disease
BERNARDINO M, YOUNG S, LEE J, WEINREB J. Contrast-Enhanced Magnetic Resonance Imaging of the Liver with Mn-DPDP for Known or Suspected Focal Hepatic Disease. Investigative Radiology 1991, 26: s148-s149. PMID: 1808113, DOI: 10.1097/00004424-199111001-00050.Peer-Reviewed Original ResearchThe Sugiura procedure for patients with hemorrhagic portal hypertension secondary to extrahepatic portal vein thrombosis.
Orozco H, Takahashi T, Mercado M, Garcia-Tsao G, Hernandez-Ortiz J. The Sugiura procedure for patients with hemorrhagic portal hypertension secondary to extrahepatic portal vein thrombosis. Journal Of The American College Of Surgeons 1991, 173: 45-8. PMID: 1866670.Peer-Reviewed Original ResearchConceptsHemorrhagic portal hypertensionPortal vein thrombosisSugiura procedurePortal hypertensionVein thrombosisActuarial survival rateAssociated hepatic diseaseHistory of omphalitisAntithrombin III deficiencyHistory of pancreatitisProtein C deficiencyOperative deathsMale patientsMean ageSurgical stageHepatic diseaseIII deficiencyPatientsSurvival rateC deficiencyHypertensionThrombosisEPVTDeficiencyLong term
1983
Diabetes mellitus and the exocrine pancreas.
Gorelick FS. Diabetes mellitus and the exocrine pancreas. The Yale Journal Of Biology And Medicine 1983, 56: 271-5. PMID: 6367237, PMCID: PMC2589620.Peer-Reviewed Original ResearchConceptsDiabetes mellitusAcute pancreatitisChronic pancreatitisConcurrent hepatic diseasePrimary diabetes mellitusPancreatic exocrine functionEffect of insulinCarbohydrate intoleranceAcute illnessGlucose intolerancePancreatic calcificationGlucagon releaseExocrine functionHepatic diseaseInsulin administrationInsulin secretionPeripheral tissuesPancreatitisEndocrine pancreasInsulin productionGlucose utilizationMellitusPortal systemDiabetesExocrine pancreas
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply