2021
Genetic variations influence brain changes in patients with attention-deficit hyperactivity disorder
Yadav S, Bhat A, Hashem S, Nisar S, Kamal M, Syed N, Temanni M, Gupta R, Kamran S, Azeem M, Srivastava A, Bagga P, Chawla S, Reddy R, Frenneaux M, Fakhro K, Haris M. Genetic variations influence brain changes in patients with attention-deficit hyperactivity disorder. Translational Psychiatry 2021, 11: 349. PMID: 34091591, PMCID: PMC8179928, DOI: 10.1038/s41398-021-01473-w.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderNeurobiology of ADHDHyperactivity disorderSevere brain injuryNew treatment modalitiesDevelopment of ADHDBrain circuit functionNovel clinical biomarkersChildhood-onset disordersStrong genetic associationNeurodevelopmental assessmentPremature birthADHD brainTreatment modalitiesBrain injuryBrain changesPrecise etiologyPsychiatric disordersAnimal modelsADHD patientsTherapeutic interventionsNeural abnormalitiesClinical biomarkersNeurodevelopmental issuesSignificant associationDifferential DNA Methylation Is Associated With Hippocampal Abnormalities in Pediatric Posttraumatic Stress Disorder
Ensink JBM, Keding TJ, Henneman P, Venema A, Papale LA, Alisch RS, Westerman Y, van Wingen G, Zantvoord J, Middeldorp CM, Mannens MMAM, Herringa RJ, Lindauer R. Differential DNA Methylation Is Associated With Hippocampal Abnormalities in Pediatric Posttraumatic Stress Disorder. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2021, 6: 1063-1070. PMID: 33964519, PMCID: PMC8568739, DOI: 10.1016/j.bpsc.2021.04.016.Peer-Reviewed Original ResearchConceptsPediatric posttraumatic stress disorderPosttraumatic stress disorderStress disorderNon-PTSD control groupAnterior hippocampal volumeDifferential DNA methylationMethylome-wide association studiesAltered gene expressionHippocampal abnormalitiesDutch cohortHippocampal volumeEpigenetic mechanismsDNA methylationU.S. cohortMethylation differencesTreatment targetsControl groupStructural neuroimaging measuresNeural abnormalitiesGene expressionStress responseAssociation studiesBiological pathwaysBrain structuresCohort
2018
The Role of Stress in the Pathogenesis and Maintenance of Obsessive-Compulsive Disorder
Adams T, Kelmendi B, Brake C, Gruner P, Badour C, Pittenger C. The Role of Stress in the Pathogenesis and Maintenance of Obsessive-Compulsive Disorder. Chronic Stress 2018, 2: 2470547018758043. PMID: 29527593, PMCID: PMC5841259, DOI: 10.1177/2470547018758043.Peer-Reviewed Original ResearchOnset of symptomsOCD symptomatologyNeuronal hypertrophyNeuronal atrophyPathophysiological relationshipLimbic circuitsLimbic circuitryFrontal cortexDorsolateral striatumPsychosocial stressGoal-directed learningNeural abnormalitiesPsychiatric symptomatologyDorsomedial striatumPreclinical researchNonspecific factorsRole of stressSymptomsCompulsive disorderSymptomatologyStriatumOCD symptomsPathogenesisIndependent causeTraumatic incidents
2015
The Intersection between Neurobiological and Psychological Theories of Substance Use Disorders
Baskin‐Sommers A, Hearon B. The Intersection between Neurobiological and Psychological Theories of Substance Use Disorders. 2015, 218-235. DOI: 10.1002/9781118726761.ch11.Peer-Reviewed Original ResearchPsychological theoriesReward processingReward-related abnormalitiesImportant psychological theoriesSpecific neural abnormalitiesReward-seeking behaviorDistress toleranceNeuroscience literatureSubstance use disordersHedonic impactNeurobiological patternsNeural abnormalitiesUse disordersSUDExcessive pursuitDefining featureClinical phenomenaMarked dysfunctionProcessingNeurobiologicalRewardBrief overviewTheoryDisordersFindingsSchizotypal Personality Disorder
Garakani A, Siever L. Schizotypal Personality Disorder. 2015, 1-7. DOI: 10.1002/9781118625392.wbecp390.ChaptersSchizotypal personality disorderPersonality disorderLack of empathySchizophrenia spectrum disordersPatterns of functioningSpectrum disorderFocus of treatmentOccupational functioningCognitive deficitsMagical thinkingNeural abnormalitiesCognitive impairmentStereotyped behaviorDopamine agonistsAntipsychotic treatmentSchizophreniaChronic disordersFunctioningHealthy controlsHealthy relativesPsychiatric hospitalizationClinical linesDisordersPhenotypic associationsFamilial studies
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