2025
The role of right ventricular systolic pressure and ARISCAT score in perioperative pulmonary risk assessment
Tatsuoka Y, He Z, Lin H, Notarianni A, Carr Z. The role of right ventricular systolic pressure and ARISCAT score in perioperative pulmonary risk assessment. Brazilian Journal Of Anesthesiology 2025, 75: 844597. PMID: 39971234, PMCID: PMC11914786, DOI: 10.1016/j.bjane.2025.844597.Peer-Reviewed Original ResearchConceptsRight ventricular systolic pressurePostoperative pulmonary complicationsArea under the curveARISCAT scoreVentricular systolic pressureReceiver operating characteristic curvePulmonary hypertensionRespiratory failureHigh-risk populationPrimary endpointRisk stratificationSurgical proceduresSystolic pressurePostoperative pulmonary complications incidenceSource of increased morbidityAssess Respiratory RiskDiagnosis of PHPreoperative risk assessmentAdjusted multivariable logistic regression modelsMultivariate logistic regression modelComposite of pneumoniaPulmonary complicationsPreoperative investigationsSecondary endpointsPulmonary aspiration
2024
Long-Term Outcomes of Patients With Apical Hypertrophic Cardiomyopathy Utilizing a New Risk Score
Hajj-Ali A, Gaballa A, Akintoye E, Jadam S, Ramchand J, Xu B, Ospina S, Thamilarasan M, Smedira N, Popovic Z, Desai M. Long-Term Outcomes of Patients With Apical Hypertrophic Cardiomyopathy Utilizing a New Risk Score. JACC Advances 2024, 3: 101235. PMID: 39512540, PMCID: PMC11540864, DOI: 10.1016/j.jacadv.2024.101235.Peer-Reviewed Original ResearchApical hypertrophic cardiomyopathyRight ventricular systolic pressureLeft atrial volume indexAtrial volume indexVentricular systolic pressureRisk scoreApical aneurysmEnd pointsHypertrophic cardiomyopathyMean left ventricle ejection fractionSystolic pressureLong-term outcomes of patientsApical hypertrophic cardiomyopathy patientsVolume indexBaseline cardiac magnetic resonanceComposite primary end pointPrimary end pointOutcomes of patientsVentricle ejection fractionDelayed gadolinium enhancementCardiac magnetic resonanceComposite end pointLong-term outcomesComposite event rateLeft ventricle apex
2023
Noninvasive determinants of pulmonary hypertension in interstitial lung disease
Joseph P, Savarimuthu S, Zhao J, Yan X, Oakland H, Cullinan M, Heerdt P, Singh I. Noninvasive determinants of pulmonary hypertension in interstitial lung disease. Pulmonary Circulation 2023, 13: e12197. PMID: 36814586, PMCID: PMC9939578, DOI: 10.1002/pul2.12197.Peer-Reviewed Original ResearchInterstitial lung diseaseFVC/DLCO ratioPH-ILDRight heart catheterizationPulmonary hypertensionHeart catheterizationILD patientsLung diseaseDiagnostic right heart catheterizationRight ventricular systolic pressurePulmonary vascular capacitanceVentricular systolic pressureCharacteristic curve analysisMaximum oxygen uptakeExertional capacityNoninvasive determinantsSystolic pressureVascular capacitancePhysiologic evaluationPatientsNoninvasive variablesMultivariate analysisMmHgDiagnostic standardPotential initiation
2021
Outcomes in Patients With Obstructive Hypertrophic Cardiomyopathy and Concomitant Aortic Stenosis Undergoing Surgical Myectomy and Aortic Valve Replacement
Desai MY, Alashi A, Popovic ZB, Wierup P, Griffin BP, Thamilarasan M, Johnston D, Svensson LG, Lever HM, Smedira NG. Outcomes in Patients With Obstructive Hypertrophic Cardiomyopathy and Concomitant Aortic Stenosis Undergoing Surgical Myectomy and Aortic Valve Replacement. Journal Of The American Heart Association 2021, 10: e018435. PMID: 34533040, PMCID: PMC8649531, DOI: 10.1161/jaha.120.018435.Peer-Reviewed Original ResearchConceptsObstructive hypertrophic cardiomyopathySevere aortic stenosisAortic valve replacementVentricular outflow tract gradientOutflow tract gradientAortic stenosisHypertrophic cardiomyopathySurgical myectomyValve replacementTract gradientRisk factorsAV areaDynamic left ventricular outflow tract gradientDynamic left ventricular outflow tract obstructionLeft ventricular outflow tract gradientLeft ventricular outflow tract obstructionUS populationRight ventricular systolic pressureSevere obstructive hypertrophic cardiomyopathySudden death risk factorsVentricular outflow tract obstructionMultivariate Cox survival analysisLeft ventricular outflow tractBackground Hypertrophic cardiomyopathyBasal septal thickness
2020
Early Outcomes of Percutaneous Pulmonary Valve Implantation with Pulsta and Melody Valves: The First Report from Korea
Kim A, Jung J, Jung Y, Shin J, Eun L, Kim N, Choi J. Early Outcomes of Percutaneous Pulmonary Valve Implantation with Pulsta and Melody Valves: The First Report from Korea. Journal Of Clinical Medicine 2020, 9: 2769. PMID: 32859019, PMCID: PMC7565703, DOI: 10.3390/jcm9092769.Peer-Reviewed Original ResearchPercutaneous pulmonary valve implantationRight ventricular outflow tractPulmonary valve implantationMelody valveValve implantationPulsta valvePulmonary regurgitationPulmonary stenosisEarly outcomesRight ventricular end-diastolic volume indexRight ventricular outflow tract dysfunctionNative right ventricular outflow tractTranscatheter pulmonary valve replacementRight ventricular systolic pressureEnd-diastolic volume indexCardiac magnetic resonance imagingMelody valve implantationTreat pulmonary stenosisPulmonary valve replacementExcellent early outcomeValve-related complicationsVentricular outflow tractVentricular systolic pressureSelf-expandable systemPorcine pericardial valveTricuspid regurgitation and in-hospital outcomes after transcatheter aortic valve replacement in high-risk patients
Omar S, Aneni E, Escolar E, Mihos CG, Xydas S, LaPietra A, Beohar N, Arenas IA. Tricuspid regurgitation and in-hospital outcomes after transcatheter aortic valve replacement in high-risk patients. Journal Of Thoracic Disease 2020, 12: 2963-2970. PMID: 32642209, PMCID: PMC7330359, DOI: 10.21037/jtd.2020.02.10.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementRight ventricular systolic pressureSignificant tricuspid regurgitationSevere aortic stenosisAortic valve replacementHigh-risk patientsSevere tricuspid regurgitationAortic valve areaTricuspid regurgitationHospital outcomesValve replacementAortic stenosisTR severityElevated right ventricular systolic pressureMean aortic valve areaMedian STS scoreLonger hospital stayVentricular systolic pressureManagement of patientsHospital mortalityCause mortalityHospital deathHospital stayLonger hospitalRisk patients
2019
Characteristics and Outcomes in a Contemporary Group of Patients With Suspected Significant Mitral Stenosis Undergoing Treadmill Stress Echocardiography
Gentry JL, Parikh PK, Alashi A, Gillinov AM, Pettersson GB, Rodriguez LL, Popovic ZB, Sato K, Grimm RA, Kapadia SR, Tuzcu EM, Svensson LG, Griffin BP, Desai MY. Characteristics and Outcomes in a Contemporary Group of Patients With Suspected Significant Mitral Stenosis Undergoing Treadmill Stress Echocardiography. Circulation Cardiovascular Imaging 2019, 12: e009062. PMID: 31203672, DOI: 10.1161/circimaging.119.009062.Peer-Reviewed Original ResearchConceptsRight ventricular systolic pressureTreadmill stress echocardiographyVentricular systolic pressureStress echocardiographySystolic pressureMetabolic equivalentsMV gradientMitral proceduresHigh mortalityThoracic Surgeons scoreLong-term survivalAsymptomatic patientsCause mortalityPrimary outcomeSurgeons scoreConsecutive patientsImproved survivalContemporary patientsMV proceduresPatientsEchocardiographySignificant MSSurvival analysisModerate MSMortality
2018
Characteristics and longer-term outcomes of paravalvular leak after aortic and mitral valve surgery
Shah S, Alashi A, Pettersson GB, Rodriguez LL, Gillinov AM, Grimm RA, Navia J, Kapadia SR, Svensson LG, Griffin BP, Desai MY. Characteristics and longer-term outcomes of paravalvular leak after aortic and mitral valve surgery. Journal Of Thoracic And Cardiovascular Surgery 2018, 157: 1785-1792.e1. PMID: 30414770, DOI: 10.1016/j.jtcvs.2018.08.096.Peer-Reviewed Original ResearchConceptsReoperative cardiac surgeryLong-term mortalityRight ventricular systolic pressureGreater paravalvular leakMitral valve surgeryVentricular systolic pressureParavalvular leakLong-term outcomesLong-term survivalSTS scoreMV surgeryValve surgeryInfectious etiologySystolic pressureMultivariable Cox survival analysisGreater long-term mortalityAortic paravalvular leakMean STS scoreThoracic Surgeons scoreMild paravalvular leakVentricular ejection fractionCox survival analysisExcellent perioperative outcomesPerioperative outcomesPrimary endpointExercise capacity in asymptomatic patients with significant primary mitral regurgitation: independent effect of global longitudinal left ventricular strain
Mentias A, Alashi A, Naji P, Gillinov AM, Rodriguez LL, Mihaljevic T, Suri RM, Grimm RA, Svensson LG, Griffin BP, Desai MY. Exercise capacity in asymptomatic patients with significant primary mitral regurgitation: independent effect of global longitudinal left ventricular strain. Cardiovascular Diagnosis And Therapy 2018, 8: 460-468. PMID: 30214861, PMCID: PMC6129839, DOI: 10.21037/cdt.2018.05.03.Peer-Reviewed Original ResearchRight ventricular systolic pressureLeft ventricular ejection fractionPrimary mitral regurgitationMean metabolic equivalentSignificant primary mitral regurgitationLV-GLSExercise capacityAsymptomatic patientsMitral regurgitationGlobal longitudinal left ventricular strainLeft ventricular global longitudinal strainMitral effective regurgitant orificeVentricular global longitudinal strainVentricular systolic pressureVentricular ejection fractionGlobal longitudinal strainFlail mitral leafletLeft ventricular strainEffective regurgitant orificeVelocity vector imagingVentricular strainEjection fractionIndependent predictorsSignificant arrhythmiasSystolic pressure
2017
Incremental Prognostic Utility of Left Ventricular Global Longitudinal Strain in Asymptomatic Patients With Significant Chronic Aortic Regurgitation and Preserved Left Ventricular Ejection Fraction
Alashi A, Mentias A, Abdallah A, Feng K, Gillinov AM, Rodriguez LL, Johnston DR, Svensson LG, Popovic ZB, Griffin BP, Desai MY. Incremental Prognostic Utility of Left Ventricular Global Longitudinal Strain in Asymptomatic Patients With Significant Chronic Aortic Regurgitation and Preserved Left Ventricular Ejection Fraction. JACC Cardiovascular Imaging 2017, 11: 673-682. PMID: 28624411, DOI: 10.1016/j.jcmg.2017.02.016.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAortic Valve InsufficiencyAsymptomatic DiseasesBiomechanical PhenomenaChronic DiseaseDisease ProgressionEchocardiography, Doppler, ColorFemaleHumansMaleMiddle AgedMyocardial ContractionPredictive Value of TestsPrognosisRetrospective StudiesRisk AssessmentRisk FactorsStroke VolumeTime FactorsVentricular Dysfunction, LeftVentricular Function, LeftConceptsLeft ventricular ejection fractionAortic valve surgeryChronic aortic regurgitationLong-term mortalityGlobal longitudinal strainRight ventricular systolic pressureVentricular global longitudinal strainLV end-systolic dimensionLV-GLSVentricular systolic pressureEnd-systolic dimensionVentricular ejection fractionAortic regurgitationAsymptomatic patientsTerm mortalityValve surgerySTS scoreEjection fractionSystolic pressurePrognostic utilityLeft ventricular global longitudinal strainMultivariable Cox survival analysisSevere chronic aortic regurgitationLongitudinal strainMean STS scoreAortic Cross-Sectional Area/Height Ratio and Outcomes in Patients With Bicuspid Aortic Valve and a Dilated Ascending Aorta
Masri A, Kalahasti V, Svensson LG, Alashi A, Schoenhagen P, Roselli EE, Johnston DR, Rodriguez LL, Griffin BP, Desai MY. Aortic Cross-Sectional Area/Height Ratio and Outcomes in Patients With Bicuspid Aortic Valve and a Dilated Ascending Aorta. Circulation Cardiovascular Imaging 2017, 10: e006249. PMID: 28592593, DOI: 10.1161/circimaging.116.006249.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnatomic LandmarksAortaAortic AneurysmAortic ValveAortographyBicuspid Aortic Valve DiseaseCause of DeathChi-Square DistributionComputed Tomography AngiographyDilatation, PathologicFemaleHeart Valve DiseasesHospital MortalityHumansKaplan-Meier EstimateMagnetic Resonance AngiographyMaleMiddle AgedMultidetector Computed TomographyMultivariate AnalysisOhioPredictive Value of TestsProportional Hazards ModelsRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsBicuspid aortic valve patientsProximal ascending aortaAortic valve patientsBicuspid aortic valveAortic areaCardiovascular deathAscending aortaAortic surgeryValve patientsAortic valveMultivariable Cox survival analysisRight ventricular systolic pressureLong-term cardiovascular mortalityContrast-enhanced thoracicThoracic Surgeons scoreSevere aortic stenosisVentricular systolic pressureCox survival analysisMagnetic resonance angiographyHeight ratioAortic regurgitationCardiovascular mortalitySurgeons scoreAortic stenosisImproved survival
2016
Synergistic Utility of Brain Natriuretic Peptide and Left Ventricular Global Longitudinal Strain in Asymptomatic Patients With Significant Primary Mitral Regurgitation and Preserved Systolic Function Undergoing Mitral Valve Surgery
Alashi A, Mentias A, Patel K, Gillinov AM, Sabik JF, Popović ZB, Mihaljevic T, Suri RM, Rodriguez LL, Svensson LG, Griffin BP, Desai MY. Synergistic Utility of Brain Natriuretic Peptide and Left Ventricular Global Longitudinal Strain in Asymptomatic Patients With Significant Primary Mitral Regurgitation and Preserved Systolic Function Undergoing Mitral Valve Surgery. Circulation Cardiovascular Imaging 2016, 9 PMID: 27342145, DOI: 10.1161/circimaging.115.004451.Peer-Reviewed Original ResearchMeSH KeywordsAgedAsymptomatic DiseasesBiomarkersCardiac Surgical ProceduresChi-Square DistributionEchocardiographyFemaleHumansKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedMitral ValveMitral Valve InsufficiencyMultivariate AnalysisMyocardial ContractionNatriuretic Peptide, BrainPredictive Value of TestsProportional Hazards ModelsRetrospective StudiesRisk AssessmentRisk FactorsStroke VolumeTime FactorsTreatment OutcomeVentricular Function, LeftVentricular Function, RightVentricular PressureConceptsLeft ventricular ejection fractionMitral valve surgeryVentricular ejection fractionLog-transformed BNPThoracic Surgeons scoreBrain natriuretic peptidePrimary mitral regurgitationRight ventricular systolic pressureSignificant primary mitral regurgitationVentricular systolic pressureGlobal longitudinal strainIncremental prognostic utilityLV-GLSAsymptomatic patientsValve surgeryEjection fractionMitral regurgitationSurgeons scoreNatriuretic peptideSystolic pressurePrognostic utilityBaseline LV global longitudinal strainBaseline right ventricular systolic pressureMitral effective regurgitant orificeLV global longitudinal strain
2014
Prognostic Usefulness of Insulin-Like Growth Factor-Binding Protein 7 in Heart Failure With Reduced Ejection Fraction: A Novel Biomarker of Myocardial Diastolic Function?
Gandhi PU, Gaggin HK, Sheftel AD, Belcher AM, Weiner RB, Baggish AL, Motiwala SR, Liu PP, Januzzi JL. Prognostic Usefulness of Insulin-Like Growth Factor-Binding Protein 7 in Heart Failure With Reduced Ejection Fraction: A Novel Biomarker of Myocardial Diastolic Function? The American Journal Of Cardiology 2014, 114: 1543-1549. PMID: 25248814, DOI: 10.1016/j.amjcard.2014.08.018.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersDisease ProgressionEchocardiography, DopplerFemaleFollow-Up StudiesHeart Failure, DiastolicHumansInsulin-Like Growth Factor Binding ProteinsMaleMiddle AgedMyocardial ContractionPrognosisProspective StudiesSeverity of Illness IndexStroke VolumeTime FactorsVentricular Function, LeftConceptsInsulin-like growth factor-binding protein 7Right ventricular systolic pressureReduced ejection fractionAtrial volume indexVentricular systolic pressureTransmitral E/Diastolic functionIGFBP7 concentrationsHeart failureEjection fractionSystolic pressureVolume indexEchocardiographic parametersHigher left atrial volume indexLeft atrial volume indexInsulin-like growth factorAmbulatory heart failureAbnormal diastolic functionMyocardial diastolic functionNovel prognostic biomarkerProtein 7Binding protein 7Echocardiographic abnormalitiesFinal echocardiogramCardiovascular events
2013
Minimally invasive fibrillating mitral valve replacement for patients with advanced cardiomyopathy: A safe and effective approach to treat a complex problem
Brittain EL, Goyal SK, Sample MA, Leacche M, Absi TS, Papa F, Churchwell KB, Ball S, Byrne JG, Maltais S, Petracek MR, Mendes L. Minimally invasive fibrillating mitral valve replacement for patients with advanced cardiomyopathy: A safe and effective approach to treat a complex problem. Journal Of Thoracic And Cardiovascular Surgery 2013, 148: 2045-2051.e1. PMID: 24332110, PMCID: PMC4050032, DOI: 10.1016/j.jtcvs.2013.10.062.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiomyopathiesDisease-Free SurvivalFemaleHeart Valve Prosthesis ImplantationHospital MortalityHumansKaplan-Meier EstimateMaleMiddle AgedMinimally Invasive Surgical ProceduresMitral ValveMitral Valve InsufficiencyPostoperative ComplicationsRecurrenceRisk FactorsSeverity of Illness IndexStroke VolumeTime FactorsTreatment OutcomeVentricular Dysfunction, LeftVentricular Function, LeftVentricular Function, RightVentricular PressureVentricular RemodelingConceptsLV ejection fractionRecurrent mitral regurgitationRight ventricular systolic pressureVentricular systolic pressureMitral valve replacementSevere mitral regurgitationMitral regurgitationAdvanced cardiomyopathyValve replacementSystolic pressureLV dimensionsThoracic surgeonsNew York Heart Association classLV end-diastolic diameterComposite of deathEnd-diastolic diameterFirst postoperative visitOperative mortalityPostoperative morbidityPostoperative visitAssociation classClinical outcomesEjection fractionDevice insertionPatients
2012
Melody Valve Implant Within Failed Bioprosthetic Valves in the Pulmonary Position
Gillespie MJ, Rome JJ, Levi DS, Williams RJ, Rhodes JF, Cheatham JP, Hellenbrand WE, Jones TK, Vincent JA, Zahn EM, McElhinney DB. Melody Valve Implant Within Failed Bioprosthetic Valves in the Pulmonary Position. Circulation Cardiovascular Interventions 2012, 5: 862-870. PMID: 23212395, DOI: 10.1161/circinterventions.112.972216.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultArterial PressureBioprosthesisCardiac CatheterizationChildChild, PreschoolEndocarditisFemaleHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHumansKaplan-Meier EstimateMaleMiddle AgedProsthesis DesignProsthesis FailurePulmonary ArteryPulmonary ValvePulmonary Valve InsufficiencyRetrospective StudiesTime FactorsTreatment OutcomeUnited StatesVentricular Function, RightVentricular PressureYoung AdultConceptsTranscatheter pulmonary valve implantationPulmonary valve implantationMelody valveValve implantationBioprosthetic valvesPulmonary positionRight ventricular outflow tract dysfunctionRight ventricular outflow tract gradientLow procedure-related morbidityRight ventricular systolic pressureVentricular outflow tract gradientExcellent short-term resultsMelody valve implantationPreliminary multicenter experiencePulmonary artery gradientTranscatheter treatment optionsOutflow tract gradientOff-label indicationsVentricular systolic pressureProcedure-related morbidityCases of endocarditisShort-term resultsBPV procedureTract gradientTract dysfunctionNicorandil Attenuates Monocrotaline-Induced Vascular Endothelial Damage and Pulmonary Arterial Hypertension
Sahara M, Sata M, Morita T, Hirata Y, Nagai R. Nicorandil Attenuates Monocrotaline-Induced Vascular Endothelial Damage and Pulmonary Arterial Hypertension. PLOS ONE 2012, 7: e33367. PMID: 22479390, PMCID: PMC3316574, DOI: 10.1371/journal.pone.0033367.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntihypertensive AgentsApoptosisBlotting, WesternCaspase 3Cells, CulturedDrug Therapy, CombinationEndothelium, VascularEnzyme InhibitorsFamilial Primary Pulmonary HypertensionGlyburideHuman Umbilical Vein Endothelial CellsHumansHypertension, PulmonaryInjections, IntraperitonealMaleMAP Kinase Signaling SystemMonocrotalineNG-Nitroarginine Methyl EsterNicorandilPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRandom AllocationRatsRats, Sprague-DawleySignal TransductionVentricular PressureConceptsRight ventricular systolic pressurePulmonary arterial hypertensionHuman umbilical vein endothelial cellsVascular endothelial damageMCT injectionArterial hypertensionEndothelial damageNitro-L-arginine methyl esterNitric oxide synthase inhibitorBeneficial effectsEndothelial NOS expressionVentricular systolic pressureVehicle-treated groupChannel blocker glibenclamideOxide synthase inhibitorChannel opener nicorandilSprague-Dawley ratsCaspase-3 expressionAnti-apoptotic effectsUmbilical vein endothelial cellsPromising therapeutic potentialBcl-2 expressionAnti-apoptotic factorsNicorandil administrationVein endothelial cellsBaseline characteristics and follow-up in patients with normal haemodynamics versus borderline mean pulmonary arterial pressure in systemic sclerosis: results from the PHAROS registry
Bae S, Saggar R, Bolster MB, Chung L, Csuka ME, Derk C, Domsic R, Fischer A, Frech T, Goldberg A, Hinchcliff M, Hsu V, Hummers L, Schiopu E, Mayes MD, McLaughlin V, Molitor J, Naz N, Furst DE, Maranian P, Steen V, Khanna D. Baseline characteristics and follow-up in patients with normal haemodynamics versus borderline mean pulmonary arterial pressure in systemic sclerosis: results from the PHAROS registry. Annals Of The Rheumatic Diseases 2012, 71: 1335-1342. PMID: 22307943, PMCID: PMC3398226, DOI: 10.1136/annrheumdis-2011-200546.Peer-Reviewed Original ResearchConceptsRight heart catheterisationPulmonary hypertensionSystemic sclerosisHigh-resolution CTNormal haemodynamicsBaseline characteristicsBorderline mean pulmonary arterial pressureHigh pulmonary vascular resistanceMean pulmonary arterial pressureRight ventricular systolic pressureAbnormal lung physiologyBaseline clinical characteristicsMean pulmonary pressureProspective longitudinal cohortPulmonary vascular resistancePulmonary arterial pressurePulmonary function testsRestrictive lung diseaseVentricular systolic pressureLong-term outcomesElevated mPAPHeart catheterisationVascular resistanceBaseline demographicsClinical characteristics
2011
Pulmonary Hypertension Assessment and Recognition of Outcomes in Scleroderma (PHAROS): Baseline Characteristics and Description of Study Population
Hinchcliff M, Fischer A, Schiopu E, Steen VD. Pulmonary Hypertension Assessment and Recognition of Outcomes in Scleroderma (PHAROS): Baseline Characteristics and Description of Study Population. The Journal Of Rheumatology 2011, 38: 2172-2179. PMID: 21844142, PMCID: PMC3230328, DOI: 10.3899/jrheum.101243.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionIncident pulmonary hypertensionPulmonary hypertensionSystemic sclerosisHigh riskBaseline characteristicsDevelopment of PAHEstimated right ventricular systolic pressureIncident pulmonary arterial hypertensionLeft-side heart diseaseRight ventricular systolic pressureCarbon monoxide diffusing capacityPAH-specific therapyPulmonary Hypertension AssessmentRight heart catheterizationPulmonary venous hypertensionVentricular systolic pressureHigh-risk subjectsInterstitial lung diseaseRecognition of OutcomesSSc-PAHArterial hypertensionHeart catheterizationVenous hypertensionSSc patients
2010
NT-Probnp as a Marker of Cardiopulmonary Compromise and Exercise Limitation In Adults with Sickle Cell Anemia In the Walk-PHaSST Study
Nouraie M, Barst R, Rosenzweig E, Sachdev V, Machado R, Hassell K, Gibbs J, Little J, Schraufnagel D, Krishnamurti L, Novelli E, Girgis R, Morris C, Badesch D, Lanzkron S, Castro O, Goldsmith J, Gladwin M, Gordeuk V, Kato G. NT-Probnp as a Marker of Cardiopulmonary Compromise and Exercise Limitation In Adults with Sickle Cell Anemia In the Walk-PHaSST Study. Blood 2010, 116: 1639. DOI: 10.1182/blood.v116.21.1639.1639.Peer-Reviewed Original ResearchElevated NT-proBNP levelsNT-proBNP levelsRight ventricular systolic pressureSickle cell anemiaVentricular systolic pressureNT-proBNP concentrationsNT-proBNPSickle cell diseasePulmonary hypertensionPositive predictive valueCell anemiaPg/Exercise limitationHeart failureSystolic pressureNatriuretic peptideCell diseaseN-terminal pro-brain natriuretic peptide levelsN-terminal pro-B-type natriuretic peptidePlasma brain natriuretic peptide concentrationPredictive valuePro-brain natriuretic peptide levelsPro-B-type natriuretic peptideCardiac natriuretic peptide systemLower NT-proBNP levelsPredictors of Six-Minute Walk Distance In Adults with Sickle Cell Anemia In the Walk-PHaSST Study
Barst R, Kato G, Sachdev V, Nouraie M, Machado R, Hassell K, Gibbs S, Little J, Schraufnagel D, Krishnamurti L, Girgis R, Morris C, Badesch D, Lanzkron S, Castro O, Rosenzweig E, Goldsmith J, Gladwin M, Gordeuk V. Predictors of Six-Minute Walk Distance In Adults with Sickle Cell Anemia In the Walk-PHaSST Study. Blood 2010, 116: 947. DOI: 10.1182/blood.v116.21.947.947.Peer-Reviewed Original ResearchHigher tricuspid regurgitation velocityTricuspid regurgitation velocitySickle cell diseaseSickle cell anemiaRight ventricular systolic pressureVentricular filling pressureVentricular systolic pressureCell anemiaCell diseaseEa ratioExercise capacitySystolic pressureFilling pressureFunctional capacityHemolytic componentElevated tricuspid regurgitant jet velocityTricuspid regurgitant jet velocitySix-minute walk distanceSix-minute walk testSickle cell disease patientsDecreased exercise capacityHemoglobin oxygen desaturationBaseline clinical characteristicsImpaired exercise capacitySickle cell anemia patients
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