2023
IRF8 in Conjunction With CD123 and CD20 to Distinguish Lupus Erythematosus Panniculitis From Subcutaneous Panniculitis-like T-Cell Lymphoma
Wong J, Roy S, McNiff J, Xu M. IRF8 in Conjunction With CD123 and CD20 to Distinguish Lupus Erythematosus Panniculitis From Subcutaneous Panniculitis-like T-Cell Lymphoma. The American Journal Of Surgical Pathology 2023, 47: 1425-1431. PMID: 37767989, DOI: 10.1097/pas.0000000000002133.Peer-Reviewed Original ResearchConceptsSubcutaneous panniculitis-like T-cell lymphomaLupus erythematosus panniculitisPanniculitis-like T-cell lymphomaCase of SPTCLT-cell lymphomaPlasmacytoid dendritic cell differentiationPlasmacytoid dendritic cellsExpression of IRF8Dendritic cell differentiationCharacteristic curve analysisImportant clinical implicationsRegulatory factor 8Dendritic cellsCutaneous biopsyLymphoid aggregatesDiagnostic challengeImmunohistochemical panelImmunohistochemical expressionCD123CD20Distinct patientsClinical implicationsSubcutaneous fatDiagnostic testsPositive markers
2019
Impact of short-term low-dose tamoxifen on molecular breast imaging background parenchymal uptake: a pilot study
Hruska CB, Hunt KN, Conners AL, Geske JR, Brandt KR, Degnim AC, Vachon CM, O’Connor M, Rhodes DJ. Impact of short-term low-dose tamoxifen on molecular breast imaging background parenchymal uptake: a pilot study. Breast Cancer Research 2019, 21: 38. PMID: 30850011, PMCID: PMC6408779, DOI: 10.1186/s13058-019-1120-5.Peer-Reviewed Original ResearchConceptsLow-dose tamoxifenMolecular breast imagingBackground parenchymal uptakeOral tamoxifenParenchymal uptakeBreast cancer risk reductionBreast cancer risk factorsEffectiveness of tamoxifenCancer risk factorsCancer risk reductionBreast cancer historyShort-term interventionMean ageCancer historyRisk factorsBreast fibroglandular tissueTamoxifenMolecular breastAverage countStudy participantsSubcutaneous fatPilot studyWomenT-testIntervention
2018
A low visceral fat proportion, independent of total body fat mass, protects obese adolescent girls against fatty liver and glucose dysregulation: a longitudinal study
Umano GR, Shabanova V, Pierpont B, Mata M, Nouws J, Tricò D, Galderisi A, Santoro N, Caprio S. A low visceral fat proportion, independent of total body fat mass, protects obese adolescent girls against fatty liver and glucose dysregulation: a longitudinal study. International Journal Of Obesity 2018, 43: 673-682. PMID: 30337653, PMCID: PMC9354568, DOI: 10.1038/s41366-018-0227-6.Peer-Reviewed Original ResearchConceptsBody fat distributionHepatic fat contentGlucose metabolismVisceral fatInsulin resistanceObese adolescentsFat distributionWhole-body insulin sensitivity indexOral glucose tolerance testTotal body fat massSubcutaneous fatIntrahepatic fat contentImpaired glucose metabolismLow ratio groupGlucose tolerance testObese adolescent girlsSubjects/methodsWeBody fat massInsulin sensitivity indexHepatic fat accumulationMajor determinantGlucose dysregulationFatty liverTolerance testFat mass
2016
Testosterone vs. aromatase inhibitor in older men with low testosterone: effects on cardiometabolic parameters
Dias J, Shardell M, Carlson O, Melvin D, Caturegli G, Ferrucci L, Chia C, Egan J, Basaria S. Testosterone vs. aromatase inhibitor in older men with low testosterone: effects on cardiometabolic parameters. Andrology 2016, 5: 31-40. PMID: 27792869, PMCID: PMC5794008, DOI: 10.1111/andr.12284.Peer-Reviewed Original ResearchConceptsC-reactive proteinTransdermal testosterone gelAromatase inhibitionTreatment armsOlder menEffects of long-term testosterone replacementTestosterone levelsLong-term testosterone replacementHomeostatic model assessment of insulin resistanceModel assessment of insulin resistanceMid-thigh fatResponse to OGTTAssessment of insulin resistanceFasting lipid levelsHomeostatic model assessmentLow testosterone levelsNon-diabetic menAbdominal subcutaneous fatLow T levelsSubcutaneous fatFasting lipidsDouble-blindPlacebo-ControlledTestosterone gelCardiometabolic parameters
2015
Lifestyle Intervention for Sleep Disturbances Among Overweight or Obese Individuals
Nam S, Stewart KJ, Dobrosielski DA. Lifestyle Intervention for Sleep Disturbances Among Overweight or Obese Individuals. Behavioral Sleep Medicine 2015, 14: 343-350. PMID: 26375410, PMCID: PMC4794423, DOI: 10.1080/15402002.2015.1007992.Peer-Reviewed Original ResearchConceptsSleep disturbancesLifestyle interventionSelf-reported sleep disturbanceWeight-loss dietsAbdominal subcutaneous fatDifferent lifestyle interventionsAbdominal total fatLess sleep disturbanceMagnetic resonance imagingMood States questionnaireLoss dietVisceral fatObese individualsOverweight personsDepressive symptomsBody weightTotal fatResonance imagingAerobic fitnessSubcutaneous fatNovel findingsState QuestionnaireFatInterventionOverweight
2008
Short‐term metabolic and cardiovascular effects of metformin in markedly obese adolescents with normal glucose tolerance
Burgert TS, Duran EJ, Goldberg‐Gell R, Dziura J, Yeckel CW, Katz S, Tamborlane WV, Caprio S. Short‐term metabolic and cardiovascular effects of metformin in markedly obese adolescents with normal glucose tolerance. Pediatric Diabetes 2008, 9: 567-576. PMID: 18761646, DOI: 10.1111/j.1399-5448.2008.00434.x.Peer-Reviewed Original ResearchConceptsNormal glucose toleranceInsulin sensitivityGlucose toleranceObese childrenDouble-blind clinical trialType 2 diabetes mellitusSubcutaneous fatCardio-metabolic consequencesBaseline insulin sensitivityImproved insulin sensitivityInsulin-resistant adolescentsHeart rate recoveryLong-term treatmentDeep subcutaneous fatShort-term useMagnetic resonance imagingPlacebo groupCardiovascular effectsDiabetes mellitusMetS groupClinical effectsLipid parametersInsulin sensitizersInflammatory cytokinesObese adolescents
2007
High Visceral and Low Abdominal Subcutaneous Fat Stores in the Obese Adolescent A Determinant of an Adverse Metabolic Phenotype
Taksali SE, Caprio S, Dziura J, Dufour S, Calí A, Goodman TR, Papademetris X, Burgert TS, Pierpont BM, Savoye M, Shaw M, Seyal AA, Weiss R. High Visceral and Low Abdominal Subcutaneous Fat Stores in the Obese Adolescent A Determinant of an Adverse Metabolic Phenotype. Diabetes 2007, 57: 367-371. PMID: 17977954, DOI: 10.2337/db07-0932.Peer-Reviewed Original ResearchConceptsMetabolic syndromeObese adolescentsInsulin resistanceVisceral fatSubcutaneous fatAdverse metabolic phenotypeC-reactive proteinSevere metabolic complicationsAbdominal subcutaneous fatBMI z-scoreProton magnetic resonance spectroscopyMulti-ethnic cohortFat-free massSubcutaneous fat depotsMagnetic resonance imagingSubcutaneous fat storesMetabolic complicationsTotal adiponectinHepatic fatLiver fatTriglyceride levelsInterleukin-6Visceral depotsOdds ratioC-peptide
2003
Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning
Weiss R, Dufour S, Taksali SE, Tamborlane WV, Petersen KF, Bonadonna RC, Boselli L, Barbetta G, Allen K, Rife F, Savoye M, Dziura J, Sherwin R, Shulman GI, Caprio S. Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning. The Lancet 2003, 362: 951-957. PMID: 14511928, PMCID: PMC2995523, DOI: 10.1016/s0140-6736(03)14364-4.Peer-Reviewed Original ResearchConceptsImpaired glucose toleranceNormal glucose toleranceGlucose toleranceObese childrenInsulin resistanceObese adolescentsGlucose disposalInsulin sensitivitySevere peripheral insulin resistanceNon-oxidative glucose metabolismSubcutaneous fatH plasma glucose concentrationsAbdominal fat partitioningVisceral lipid contentsPeripheral glucose disposalHigher intramyocellular lipid contentAbdominal fat distributionDegree of obesityIntramyocellular lipid contentPeripheral insulin resistanceHigh visceral fatAbdominal subcutaneous fatEuglycaemic hyperinsulinaemic clampSevere insulin resistancePlasma glucose concentration
2002
The Effects of Rosiglitazone on Insulin Sensitivity, Lipolysis, and Hepatic and Skeletal Muscle Triglyceride Content in Patients With Type 2 Diabetes
Mayerson AB, Hundal RS, Dufour S, Lebon V, Befroy D, Cline GW, Enocksson S, Inzucchi SE, Shulman GI, Petersen KF. The Effects of Rosiglitazone on Insulin Sensitivity, Lipolysis, and Hepatic and Skeletal Muscle Triglyceride Content in Patients With Type 2 Diabetes. Diabetes 2002, 51: 797-802. PMID: 11872682, PMCID: PMC2995527, DOI: 10.2337/diabetes.51.3.797.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAdipose TissueBlood GlucoseBody CompositionCalorimetry, IndirectDiabetes Mellitus, Type 2Fatty AcidsGlucose Clamp TechniqueGlycated HemoglobinGlycerolHumansHyperinsulinismInsulinKineticsLipidsLipolysisLiverMagnetic Resonance SpectroscopyMicrodialysisMiddle AgedMuscle, SkeletalOxidation-ReductionRosiglitazoneThiazolesThiazolidinedionesTriglyceridesConceptsPlasma fatty acid concentrationsMuscle triglyceride contentEffects of rosiglitazoneType 2 diabetesInsulin sensitivityPeripheral adipocytesTriglyceride contentRosiglitazone treatmentFatty acid concentrationsTwo-step hyperinsulinemic-euglycemic clampSkeletal muscle triglyceride contentType 2 diabetic subjectsInsulin-stimulated glucose metabolismWhole-body insulin sensitivityExtramyocellular lipid contentInsulin-responsive organHepatic triglyceride contentHyperinsulinemic-euglycemic clampAdipocyte insulin sensitivityDiabetic subjectsInsulin clampGlucose metabolismGlycerol releaseResponsive organSubcutaneous fat
1994
Localized 13C NMR Spectroscopy in the Human Brain of Amino Acid Labeling from d‐[1‐13C]Glucose
Gruetter R, Novotny E, Boulware S, Mason G, Rothman D, Shulman G, Prichard J, Shulman R. Localized 13C NMR Spectroscopy in the Human Brain of Amino Acid Labeling from d‐[1‐13C]Glucose. Journal Of Neurochemistry 1994, 63: 1377-1385. PMID: 7931289, DOI: 10.1046/j.1471-4159.1994.63041377.x.Peer-Reviewed Original Research
1986
Effects of Local Heat on Blood Flow in Infected and Normal Hands
Gahhos F, Caride V, Ariyan S, Arons M. Effects of Local Heat on Blood Flow in Infected and Normal Hands. Plastic & Reconstructive Surgery 1986, 78: 353-359. PMID: 3737759, DOI: 10.1097/00006534-198609000-00012.Peer-Reviewed Original ResearchConceptsBlood flowNormal handInfected handMuscle blood flowSubcutaneous blood flowNormal tissues resultsDermal blood flowTopical heatHand infectionsSubcutaneous circulationSubcutaneous fatClearance dataNormal patternTissue resultsPatientsDeeper tissue layersInfected tissuesInfectionSuperficial tissuesTissueTissue layersLocal heatShuntingTraditional beliefsBlood
1981
Ultrastructure of the Human Dermal Microcirculation. III. The Vessels in the Mid- and Lower Dermis and Subcutaneous Fat
Braverman I, Keh-Yen A. Ultrastructure of the Human Dermal Microcirculation. III. The Vessels in the Mid- and Lower Dermis and Subcutaneous Fat. Journal Of Investigative Dermatology 1981, 77: 297-304. PMID: 7264363, DOI: 10.1111/1523-1747.ep12482470.Peer-Reviewed Original ResearchConceptsElastic laminaSubcutaneous fatEndothelial cellsHuman Dermal MicrocirculationInternal elastic laminaLower dermisExamination of vesselsVeil cellsButtock skinDermal capillariesLarge arteriesArteriolesDermal microcirculationSweat glandsMicrocirculatory vesselsBlood vesselsVenous capillariesVessel wallUltrastructural featuresHair bulbDermisNormal thicknessElastic fibersFatVenules
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