2025
Investigation of NPM1 mutation frequency in cutaneous blastic plasmacytoid dendritic cell neoplasms
Hamdan H, Siddon A, Ramia de Cap M, Germans S, Cantu M, Fuda F, Vandergriff T, Aggarwal N, Weinberg O. Investigation of NPM1 mutation frequency in cutaneous blastic plasmacytoid dendritic cell neoplasms. Human Pathology 2025, 158: 105766. PMID: 40216030, DOI: 10.1016/j.humpath.2025.105766.Peer-Reviewed Original ResearchConceptsBlastic plasmacytoid dendritic cell neoplasmBPDCN patientsBPDCN casesCutaneous blastic plasmacytoid dendritic cell neoplasmAcute myeloid leukemiaPlasmacytoid dendritic cell neoplasmDendritic cell neoplasmNPM1 mutationsMyeloid sarcomaCell neoplasmsSarcoma patientsImmunohistochemical stainingAbsence of NPM1 mutationsFrequency of NPM1 mutationsBone marrow of patientsLow white blood cell countCutaneous myeloid sarcomaWhite blood cell countMarrow of patientsTime of diagnosisHigher hemoglobin levelsBlood cell countPercentage of involvementSRSF2 mutationsComplex karyotype
2024
Histologic Features of Mycobacterial Spindle Cell Pseudotumors
Szczepanski J, Lieberman J, Lamps L, Gonzalez R, Xue Y, Zhang X, Yilmaz O, Hart J, Krausz T, Mantilla J, McHugh J, Westerhoff M. Histologic Features of Mycobacterial Spindle Cell Pseudotumors. The American Journal Of Surgical Pathology 2024, 48: 890-900. PMID: 38726848, DOI: 10.1097/pas.0000000000002234.Peer-Reviewed Original ResearchConceptsMycobacterial spindle cell pseudotumorSpindle cell pseudotumorImmunocompromised patientsFoamy histiocytesLymph nodesNeutrophilic inflammationNeutrophilic microabscessesEvaluated lymph nodesComposition of inflammatory infiltratesSpindle cell neoplasmSecondary to infectionNon-tuberculous mycobacteriaArchitectural growth patternAcid-fast stainingMultinucleated giant cellsPeripheral granulomaSurgical therapyCell neoplasmsStromal changesHistological factorsSpindle cellsLymphocytic inflammationMicrobiological findingsClinical historyInflammatory infiltrate
2023
Rare cases of colonic schwannomas
Gazivoda V, Wang D, Siddique M, Zeng J, Robert M, Pantel H, Mongiu A. Rare cases of colonic schwannomas. Journal Of Surgical Case Reports 2023, 2023: rjac438. PMID: 38163055, PMCID: PMC10757069, DOI: 10.1093/jscr/rjac438.Peer-Reviewed Original ResearchSpindle cell neoplasmTransverse colonMesenchymal tumorsCell neoplasmsProximal transverse colonSegmental transverse colectomyRare spindle cell tumorSpindle cell tumorsColonic schwannomaJumbo forcepsTransverse colectomyPrimary anastomosisSurveillance colonoscopyMucosal biopsiesSubmucosal lesionsColon massElderly malesSubmucosal resectionCell tumorsDeep biopsyElderly femalesSurgical decisionNinth caseRare caseCT scanMachine Learning Models Predict Molecular Genetic Subtypes of Multiple Myeloma from Whole-Slide Bone Marrow Aspirate Smears
Lewis J, Shebelut C, Attieh M, Horwath M, Khanna A, Al-Rusan O, Ponnatt T, Smith G, Gutman D, Gupta V, Aljudi A, Cooper L, Jaye D. Machine Learning Models Predict Molecular Genetic Subtypes of Multiple Myeloma from Whole-Slide Bone Marrow Aspirate Smears. Blood 2023, 142: 7158. DOI: 10.1182/blood-2023-190686.Peer-Reviewed Original ResearchPlasma cell neoplasmsMolecular genetic subtypesBone marrow aspirate smearsMarrow aspirate smearsCell neoplasmsPlasma cellsAspirate smearsMultiple myelomaGenetic subtypesRisk stratificationBone marrow biopsy samplesCurrent prognostic systemsRisk stratification toolCommon hematologic malignancyPlasma cell morphologyMultiple myeloma casesSpecific morphologic featuresSubset of casesRecurrent genetic abnormalitiesLow-resource settingsBiologic subtypeStratification toolAggressive diseaseScanned whole slide imagesHematologic malignanciesIRF8 may be a useful marker for blastic plasmacytoid dendritic cell neoplasm, especially with weak CD123 expression
Tang H, Panse G, Braddock D, Perincheri S, Xu M, McNiff J. IRF8 may be a useful marker for blastic plasmacytoid dendritic cell neoplasm, especially with weak CD123 expression. Journal Of Cutaneous Pathology 2023, 50: 595-600. PMID: 37082914, DOI: 10.1111/cup.14439.Peer-Reviewed Original ResearchConceptsBlastic plasmacytoid dendritic cell neoplasmPlasmacytoid dendritic cell neoplasmDendritic cell neoplasmPunch biopsy specimenBiopsy specimenCell neoplasmsCase of BPDCNUseful markerTumor cellsTCL-1 expressionAtypical mononuclear cellsBone marrow involvementDiffuse dermal infiltrateDendritic cell lineagePotential diagnostic pitfallRegulatory factor 8TCL-1BPDCN casesCD123 expressionMarrow involvementDermal infiltrateCutaneous nodulesMyelodysplastic syndromeSkin nodulesMononuclear cellsAdvances in myelodysplastic syndromes: promising novel agents and combination strategies
Madanat Y, Xie Z, Zeidan A. Advances in myelodysplastic syndromes: promising novel agents and combination strategies. Expert Review Of Hematology 2023, 16: 51-63. PMID: 36620919, DOI: 10.1080/17474086.2023.2166923.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHigh-risk myelodysplastic syndromeMultiple novel agentsMyelodysplastic syndromeNovel agentsClinical trialsTreatment optionsPhase III clinical trialsSelect clinical trialsLow-risk diseaseClonal hematopoietic stem cell neoplasmHigh-risk diseaseBest treatment optionHematopoietic stem cell neoplasmsInnate immune systemStem cell neoplasmMechanism of actionHMA therapyEarly safetyTreatment paradigmEfficacy dataCell neoplasmsDrug combinationsClinical developmentUnmet needImmune system
2022
Concurrent IRF4 Rearrangements in a Patient with B Cell and T Cell Disorders
Bernhisel A, Siddon A, Katz S. Concurrent IRF4 Rearrangements in a Patient with B Cell and T Cell Disorders. American Journal Of Clinical Pathology 2022, 158: s105-s105. DOI: 10.1093/ajcp/aqac126.221.Peer-Reviewed Original ResearchDiffuse large B-cell lymphomaIRF4 rearrangementB cellsCD30-positive T-cell lymphoproliferative disordersT-cell lymphoproliferative disorderLarge B-cell lymphomaPast medical historyT-cell lesionsCell lymphoproliferative disordersT-cell disordersB-cell lymphomaT-cell neoplasmsT cell linesIRF4 gene rearrangementT cell developmentLymphomatoid papulosisHodgkin's diseaseHematopoietic progenitor cellsLymphoproliferative disordersIntroduction/ObjectiveCase reportMedical historyCommon lymphoid progenitorsCell lesionsCell neoplasmsUtility of liquid biopsy (LB)-based comprehensive genomic profiling (CGP) of circulating tumor DNA (ctDNA) in lymphomas and plasma cell neoplasms.
Mata D, Shanmugam V, Decker B, Schrock A, Tukachinsky H, Williams E, Ross J, Montesion M, Oxnard G, Vergilio J, Xu M, Benhamida J. Utility of liquid biopsy (LB)-based comprehensive genomic profiling (CGP) of circulating tumor DNA (ctDNA) in lymphomas and plasma cell neoplasms. Journal Of Clinical Oncology 2022, 40: e19543-e19543. DOI: 10.1200/jco.2022.40.16_suppl.e19543.Peer-Reviewed Original ResearchDiffuse large B-cell lymphomaComprehensive genomic profilingNon-Hodgkin lymphomaPlasma cell neoplasmsPathogenic alterationsCell neoplasmsHybrid-capture next-generation sequencingLarge B-cell lymphomaRoutine clinical careActionable genomic alterationsGenomic alterationsHodgkin's lymphoma casesTumor biopsy specimensB-cell lymphomaPathogenic genomic alterationsUnique patient samplesRetrospective studyBiopsy specimensClinical careLymphoma casesTissue biopsiesLymphomaInsufficient tumorTumor DNAGenomic profilingCopy number variations identified in thyroid FNA specimens are associated with Hürthle cell cytomorphology
Abi‐Raad R, Prasad ML, Adeniran AJ, Cai G. Copy number variations identified in thyroid FNA specimens are associated with Hürthle cell cytomorphology. Cancer Cytopathology 2022, 130: 415-422. PMID: 35332982, DOI: 10.1002/cncy.22569.Peer-Reviewed Original ResearchConceptsHürthle cell neoplasmsThyroid FNA casesHürthle cell changeFNA casesFollicular neoplasmCell changesHürthle cell featuresFine needle aspiration diagnosisHürthle cell typeHürthle cell lesionsCopy number variationsThyroid FNA specimensCell typesSurgical managementUndetermined significanceFLUS casesCell lesionsCell neoplasmsHigh prevalenceFollicular lesionsAspiration diagnosisFNA specimensMolecular alterationsPossible associationNeoplasms
2021
Plasmacytoid dendritic cell expansion defines a distinct subset of RUNX1-mutated acute myeloid leukemia
Xiao W, Chan A, Waarts M, Mishra T, Liu Y, Cai S, Yao J, Gao Q, Bowman R, Koche R, Csete I, DelGaudio N, Derkach A, Baik J, Yanis S, Famulare C, Patel M, Arcila M, Stahl M, Rampal R, Tallman M, Zhang Y, Dogan A, Goldberg A, Roshal M, Levine R. Plasmacytoid dendritic cell expansion defines a distinct subset of RUNX1-mutated acute myeloid leukemia. Blood 2021, 137: 1377-1391. PMID: 32871587, PMCID: PMC7955409, DOI: 10.1182/blood.2020007897.Peer-Reviewed Original ResearchConceptsBlastic plasmacytoid dendritic cell neoplasmPlasmacytoid dendritic cellsAcute myeloid leukemiaPDC expansionPDC-AMLRUNX1-mutated acute myeloid leukemiaRUNX1 mutationsLeukemic blastsDendritic cellsMyeloid leukemiaCross-lineage antigen expressionPlasmacytoid dendritic cell differentiationPlasmacytoid dendritic cell neoplasmPatient-derived xenograft modelsAcute myeloid leukemia casesMature plasmacytoid dendritic cellsPlasmacytoid dendritic cell precursorsDendritic cell expansionChronic myelomonocytic leukemiaDendritic cell neoplasmPotential treatment approachTranscriptional programsCD123 targetingLeukemic burdenCell neoplasms
2017
Post-obstructive cyst formation in pancreas and cystic acinar transformation: Are they same?
Zhang X, Zhu H, Yang X, Adsay VN, Jain D. Post-obstructive cyst formation in pancreas and cystic acinar transformation: Are they same? Pathology - Research And Practice 2017, 213: 997-1001. PMID: 28599853, DOI: 10.1016/j.prp.2017.03.013.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaAcinar cell differentiationCystic dilatationCystic lesionsNon-neoplastic cystic lesionsCyst formationEtiology of obstructionCareful gross examinationBenign pancreatic cystic lesionsPancreatic ductal systemPancreatic neuroendocrine tumorsPancreatic cystic lesionsCell differentiationAcinar cell cystadenomaObstructive lesionsAcinar cell neoplasmsExact pathogenesisHistologic findingsSized cystsCystic dilationNeuroendocrine tumorsPancreatic ductDuctal adenocarcinomaCell neoplasmsMetaplastic phenomenon
2016
Expression of Markers of Hepatocellular Differentiation in Pancreatic Acinar Cell Neoplasms
Askan G, Deshpande V, Klimstra D, Adsay V, Sigel C, Shia J, Basturk O. Expression of Markers of Hepatocellular Differentiation in Pancreatic Acinar Cell Neoplasms. American Journal Of Clinical Pathology 2016, 146: 163-169. PMID: 27425386, PMCID: PMC5731433, DOI: 10.1093/ajcp/aqw096.Peer-Reviewed Original ResearchConceptsAcinar cell carcinomaMRNA in situ hybridizationAlbumin mRNA in situ hybridizationIn situ hybridizationGlypican-3Arginase 1Hepatocellular carcinomaMorphologic similarity to hepatocellular carcinomaHepatocyte paraffin antigen 1Marker of hepatocellular differentiationPancreatic acinar cell carcinomaExpressing arginase 1Acinar cell neoplasmsMessenger RNAAlbumin messenger RNARare tumorCell neoplasmsCell carcinomaHepPar-1Tissue microarrayDiagnostic challengeHepatocellular differentiationPancreatic neoplasmsA-fetoproteinDiagnostic valueEndoscopic ultrasound-guided fine-needle aspiration diagnosis of secondary tumors involving the pancreas: An institution's experience
Alomari AK, Ustun B, Aslanian HR, Ge X, Chhieng D, Cai G. Endoscopic ultrasound-guided fine-needle aspiration diagnosis of secondary tumors involving the pancreas: An institution's experience. CytoJournal 2016, 13: 1. PMID: 26955395, PMCID: PMC4763477, DOI: 10.4103/1742-6413.173585.Peer-Reviewed Original ResearchEndoscopic ultrasound-guided fine-needle aspirationSecondary tumorsAncillary studiesPrior historyDiagnostic pitfallsEndoscopic ultrasound‐guided fine‐needle aspiration diagnosisUltrasound-guided fine-needle aspirationLarge B-cell lymphomaFine needle aspiration diagnosisCommon metastatic tumorsRenal cell carcinomaB-cell lymphomaFine-needle aspirationPrimary pancreatic carcinomaMetastatic sarcomaClinical presentationSecondary involvementInstitution experienceLymphoproliferative disordersMetastatic carcinomaCell carcinomaMean ageMetastatic tumorsLung carcinomaCell neoplasms
2014
Malignancy risk and reproducibility associated with atypia of undetermined significance on thyroid cytology
Mathur A, Najafian A, Schneider E, Zeiger M, Olson M. Malignancy risk and reproducibility associated with atypia of undetermined significance on thyroid cytology. Surgery 2014, 156: 1471-1476. PMID: 25218896, DOI: 10.1016/j.surg.2014.08.026.Peer-Reviewed Original ResearchConceptsMalignancy riskUndetermined significanceAvailable surgical pathologyDiagnosis of AUSTertiary care centerFocal nuclear atypiaFine-needle aspiration specimensHürthle cell neoplasmsOutside diagnosisMalignancy rateCare centerCell neoplasmsMorphologic predictorsHigh riskNuclear atypiaSurgical pathologyBethesda SystemAUS subcategoriesAspiration specimensGreater riskThyroid CytopathologyThyroid cytologyAtypiaDiagnosisAUSRisk stratification in follicular neoplasm: A cytological assessment using the modified bethesda classification
Ustun B, Chhieng D, Van Dyke A, Carling T, Holt E, Udelsman R, Adeniran AJ. Risk stratification in follicular neoplasm: A cytological assessment using the modified bethesda classification. Cancer Cytopathology 2014, 122: 536-545. PMID: 24753500, DOI: 10.1002/cncy.21425.Peer-Reviewed Original ResearchConceptsHürthle cell neoplasmsFollicular neoplasmPapillary thyroid carcinomaFollicular lesionsBethesda classificationRisk stratificationFollicular variantThyroid carcinomaCytological diagnosisThyroid fine-needle aspiration (FNA) casesThyroid cytologyAggressive surgical managementHigh positive predictive valueSurgical pathology reportsPositive predictive valueFine-needle aspiration casesSurgical managementPathology reportsCell neoplasmsCurrent recommendationsNuclear atypiaCytology recordsCytological assessmentDiagnostic lobectomyNeoplasms
2013
Cytomorphologic and immunophenotypical features of acinar cell neoplasms of the pancreas
Sigel C, Klimstra D. Cytomorphologic and immunophenotypical features of acinar cell neoplasms of the pancreas. Cancer Cytopathology 2013, 121: 459-470. PMID: 23408736, DOI: 10.1002/cncy.21279.Peer-Reviewed Original ResearchConceptsAcinar cell carcinomaAcinar cell neoplasmsCell neoplasmsCell carcinomaMixed acinar-neuroendocrine carcinomaPreoperative cytological diagnosisAcinar-neuroendocrine carcinomaAtypical ductal cellsSolid pseudopapillary neoplasmAcinar cell cystadenomaCarcinoma histologyCytohistological correlationNeuroendocrine tumorsImmunophenotypic featuresNeuroendocrine differentiationCytological diagnosisHistological diagnosisMIB-1Cytology specimensPseudopapillary neoplasmChronic pancreatitisDiscordant diagnosesInstitutional databaseDuctal adenocarcinomaTumor cells
2012
Neoadjuvant imatinib for borderline resectable GIST.
Koontz MZ, Visser BM, Kunz PL. Neoadjuvant imatinib for borderline resectable GIST. Journal Of The National Comprehensive Cancer Network 2012, 10: 1477-82; quiz 1482. PMID: 23221786, DOI: 10.6004/jnccn.2012.0154.Peer-Reviewed Original ResearchConceptsGastrointestinal stromal tumorsNeoadjuvant imatinibNeoadjuvant tyrosine kinase-inhibitor therapyResectable gastrointestinal stromal tumorsTyrosine kinase inhibitor therapyBorderline resectable tumorsCommon bile ductSuperior mesenteric veinKinase inhibitor therapyOptimal imaging modalityViable treatment strategySpindle cell neoplasmResectable tumorsRed blood cellsUpper endoscopyBlack stoolInhibitor therapyBile ductMedical oncologyStromal tumorsEmergency departmentCase reportMesenteric veinCell neoplasmsTreatment strategiesManagement of Ovarian and Testicular Sex Cord-stromal Tumors in Children and Adolescents
Schultz KA, Schneider DT, Pashankar F, Ross J, Frazier L. Management of Ovarian and Testicular Sex Cord-stromal Tumors in Children and Adolescents. Journal Of Pediatric Hematology/Oncology 2012, 34: s55-s63. PMID: 22525408, DOI: 10.1097/mph.0b013e31824e3867.Peer-Reviewed Original ResearchConceptsSex cord-stromal tumorsTesticular sex cord-stromal tumorsOvarian sex cord-stromal tumorsManagement of ovarianTesticular stromal tumorsHigh-risk diseaseGerm cell neoplasmsOptimal treatment strategyMultiagent chemotherapyObstetrics classificationPalpable massBenign courseRisk diseaseStromal tumorsRare tumorSpecific genetic syndromesOvarian carcinomaCell neoplasmsTreatment strategiesHormone productionTumorsGenetic syndromesInternational FederationAdditional researchChildren
2010
Overview of the Lymphoid Neoplasms
Podoltsev N, Lacy J, Vose J. Overview of the Lymphoid Neoplasms. 2010, 3-39. DOI: 10.1007/978-1-4419-7668-0_1.Peer-Reviewed Original ResearchNon-Hodgkin lymphomaHodgkin's lymphomaPathogenesis of lymphomaHistologic featuresEtiologic factorsCommon subtypeWHO classificationTreatment outcomesCell neoplasmsClinical aspectsClinical groupingLymphoid malignanciesLymphoma pathogenesisLymphoid cellsLymphoid neoplasmsNormal lymphocytesLymphomaImmune systemDistinct subtypesNeoplasmsLymphocyte developmentSecond portionPathogenesisSubtypesGenetic events
2008
Synovial Sarcoma of the Stomach
Makhlouf HR, Ahrens W, Agarwal B, Dow N, Marshalleck JJ, Lee EL, Dotto JE, Hui P, Sobin LH, Oliveira A, Miettinen M. Synovial Sarcoma of the Stomach. The American Journal Of Surgical Pathology 2008, 32: 275-281. PMID: 18223331, DOI: 10.1097/pas.0b013e31812e6a58.Peer-Reviewed Original ResearchConceptsSynovial sarcomaTumor sizeSYT-SSX fusion transcriptsGastric synovial sarcomaGastric primary tumorSpindle cell neoplasmRound cell componentFocal keratinPartial gastrectomyPostoperative radiationMedian ageSegmental resectionVariable prognosisRecurrence 6Immunohistochemical featuresPrimary tumorKIT immunoreactivityMicroscopic calcificationCell neoplasmsTumors 25Differential diagnosisGastrointestinal tractOval lesionTransmural massPatients
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