2024
Histologic Features of Mycobacterial Spindle Cell Pseudotumors
Szczepanski J, Lieberman J, Lamps L, Gonzalez R, Xue Y, Zhang X, Yilmaz O, Hart J, Krausz T, Mantilla J, McHugh J, Westerhoff M. Histologic Features of Mycobacterial Spindle Cell Pseudotumors. The American Journal Of Surgical Pathology 2024, 48: 890-900. PMID: 38726848, DOI: 10.1097/pas.0000000000002234.Peer-Reviewed Original ResearchConceptsMycobacterial spindle cell pseudotumorSpindle cell pseudotumorImmunocompromised patientsFoamy histiocytesLymph nodesNeutrophilic inflammationNeutrophilic microabscessesEvaluated lymph nodesComposition of inflammatory infiltratesSpindle cell neoplasmSecondary to infectionNon-tuberculous mycobacteriaArchitectural growth patternAcid-fast stainingMultinucleated giant cellsPeripheral granulomaSurgical therapyCell neoplasmsStromal changesHistological factorsSpindle cellsLymphocytic inflammationMicrobiological findingsClinical historyInflammatory infiltrate
2023
Colorectal Carcinoma With Sarcomatoid Components
Golconda U, McHugh K, Allende D, Collins K, Henn P, Lacambra M, Bejarano P, Groisman G, Loughrey M, Monappa V, Zhang X, Hornick J, Gonzalez R. Colorectal Carcinoma With Sarcomatoid Components. The American Journal Of Surgical Pathology 2023, 48: 465-474. PMID: 38155543, DOI: 10.1097/pas.0000000000002172.Peer-Reviewed Original ResearchConceptsSarcomatoid componentColorectal carcinomaUndifferentiated carcinomaTumor-infiltrating lymphocytesNodal metastasisAbdominal painDistant metastasisRare subtypeSMARCA4 lossTumor buddingHeterologous elementsRepair protein expressionRectosigmoid regionSpindle cellsGastrointestinal bleedingKeratin-positivePoor prognosisFollow-upCarcinomaMismatch repair protein expressionMolecular testingAdvanced stageTumorLoss of mismatch repair protein expressionProtein expression
2022
Pleomorphic Carcinoma Versus Sarcomatoid Malignant Mesothelioma
Baine M, Cai G, Zhang X. Pleomorphic Carcinoma Versus Sarcomatoid Malignant Mesothelioma. Practical Anatomic Pathology 2022, 137-145. DOI: 10.1007/978-3-031-14402-8_23.Peer-Reviewed Original ResearchSarcomatoid malignant mesotheliomaPleomorphic carcinomaMalignant mesotheliomaGiant cell carcinomaCell lung carcinomaSmall biopsy specimensPleural involvementPeripheral tumorsClinicopathologic featuresUpper lobeSarcomatoid morphologyCell carcinomaBiopsy specimensLung carcinomaLung parenchymaMalignant tumorsSpindle cellsAnatomic localizationChest wallCarcinomaGiant cellsMesotheliomaLungTumorsCellsKi‐67 index assessment on FNA specimens of gastrointestinal stromal tumor: Correlation with mitotic rate and potential predictive value for risk stratification
Wang X, Abi‐Raad R, Tang H, Cai G. Ki‐67 index assessment on FNA specimens of gastrointestinal stromal tumor: Correlation with mitotic rate and potential predictive value for risk stratification. Cancer Cytopathology 2022, 130: 974-982. PMID: 35876606, DOI: 10.1002/cncy.22630.Peer-Reviewed Original ResearchConceptsGastrointestinal stromal tumorsKi-67 indexHigh mitotic rateLow mitotic rateCell block sectionsMitotic rateMitotic countRisk stratificationStromal tumorsSurgical specimensRisk of GISTCytology specimensMean Ki-67 indexPotential predictive valueBlock sectionsFine-needle aspiration specimensKi-67 immunostainLMR groupSurgical resectionDistal esophagusTumor sizeSpindle cellsGIST casesFNA specimensPredictive value
2016
Undifferentiated Carcinoma With Osteoclastic Giant Cells of the Pancreas
Muraki T, Reid M, Basturk O, Jang K, Bedolla G, Bagci P, Mittal P, Memis B, Katabi N, Bandyopadhyay S, Sarmiento J, Krasinskas A, Klimstra D, Adsay V. Undifferentiated Carcinoma With Osteoclastic Giant Cells of the Pancreas. The American Journal Of Surgical Pathology 2016, 40: 1203-1216. PMID: 27508975, PMCID: PMC4987218, DOI: 10.1097/pas.0000000000000689.Peer-Reviewed Original ResearchConceptsOsteoclastic giant cellsUndifferentiated carcinomaDuctal adenocarcinomaMean size of invasive cancersSize of invasive cancersResectable pancreatic ductal adenocarcinomaGiant cellsHistiocytic markers CD68Osteoclastic cellsPapillary mucinous neoplasmPancreatic ductal adenocarcinomaTumoral intraepithelial neoplasmsNodal metastasisRare tumorAdenocarcinoma componentPerineural invasionTumor sizeAggressive tumorsInvasive cancerClinicopathological characteristicsIntraepithelial neoplasmMucinous neoplasmsFemale predominanceSpindle cellsPancreatic cancer
2005
Cellular hamartoma resembling gastrointestinal stromal tumor: a solid tumor of the pancreas expressing c-kit (CD117)
Pauser U, da Silva M, Placke J, Klimstra D, Klöppel G. Cellular hamartoma resembling gastrointestinal stromal tumor: a solid tumor of the pancreas expressing c-kit (CD117). Modern Pathology 2005, 18: 1211-1216. PMID: 15803185, DOI: 10.1038/modpathol.3800406.Peer-Reviewed Original ResearchConceptsGastrointestinal stromal tumorsSolid tumorsStromal tumorsCytologically bland spindle cellsBland spindle cellsCoexpression of CD34Benign courseUnusual histologyC-kitSpindle cellsAdult patientsInsulin-producing cellsImmunohistochemical stainingFollow-upChromogranin ATumorDuctal cellsFibrotic tissueBcl-2Interlobular ductsCD117PancreasHamartomaPatientsCells
2004
Benign Fibroblastic Polyps of the Colon
Eslami-Varzaneh F, Washington K, Robert ME, Kashgarian M, Goldblum JR, Jain D. Benign Fibroblastic Polyps of the Colon. The American Journal Of Surgical Pathology 2004, 28: 374-378. PMID: 15104300, DOI: 10.1097/00000478-200403000-00010.Peer-Reviewed Original ResearchConceptsMucosal polypsHyperplastic polypsInflammatory fibroid polypGastrointestinal stromal tumorsSpindle cell proliferationBland spindled cellsPanel of antibodiesSmooth muscle actinBenign fibroblastic polypsAssociated adenomasFibroid polypEndoscopic findingsStromal polypsClinicopathologic featuresStromal tumorsSparse cytoplasmic organellesImmunohistochemical findingsFibroblastic featuresNeural tumorsFocal reactivityPolyposis syndromeSpindled cellsMuscularis mucosaeSpindle cellsLamina propria
2003
Nephrogenic fibrosing dermopathy: the first 6 years
Cowper SE. Nephrogenic fibrosing dermopathy: the first 6 years. Current Opinion In Rheumatology 2003, 15: 785-790. PMID: 14569211, DOI: 10.1097/00002281-200311000-00017.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsNephrogenic fibrosing dermopathyRecent case reportsCase reportCutaneous fibrosing disorderYellow scleral plaquesDistinct clinical patternsDual immunohistochemical stainingAntiphospholipid antibodiesRenal insufficiencyClinical patternDual immunolabelingFibrosing disorderSystemic disordersClinical spectrumScleral plaquesDisease onsetEpidemiologic dataSpindle cellsImmunohistochemical stainingDisease triggersSkin conditionsDisease pathogenesisNormal skinRegistry projectDiagnostic testsNephrogenic Fibrosing Dermopathy: An Unusual Skin Condition Associated with Kidney Disease
Perazella MA, Ishibe S, Perazella MA, Reilly RF. Nephrogenic Fibrosing Dermopathy: An Unusual Skin Condition Associated with Kidney Disease. Seminars In Dialysis 2003, 16: 276-280. PMID: 12753692, DOI: 10.1046/j.1525-139x.2003.16053.x.BooksConceptsCommon patient complaintLong-term hemodialysisNephrogenic fibrosing dermopathyCorticosteroid therapyInflammatory cellsKidney diseasePatient complaintsMucin depositsSkin biopsiesSpindle cellsSkin disordersFibroblast-type cellsReticular dermisCollagen bundlesInternal organsIncreased numberHemodialysisPatientsSclerodermaDisordersCellsDysesthesiaPruritusBiopsyDysfunction
2001
Nephrogenic Fibrosing Dermopathy
Cowper S, Su L, Bhawan J, Robin H, LeBoit P. Nephrogenic Fibrosing Dermopathy. American Journal Of Dermatopathology 2001, 23: 383-393. PMID: 11801769, DOI: 10.1097/00000372-200110000-00001.Peer-Reviewed Original ResearchConceptsNephrogenic fibrosing dermopathyElastic fibersPositive dermal dendrocytesCollagen bundlesDifferent kidney diseasesThick collagen bundlesRenal transplantCutaneous changesDendritic cellsFibrosing disorderRenal diseaseSystemic findingsIndurated plaquesDermal mucinKidney diseaseSingle institutionDermal dendrocytesDialysis centersHistopathologic examinationHistopathologic findingsRenal dialysisEntire dermisSpindle cellsEarly lesionsRoutine microscopy
1999
Morphea Limited to the Superficial Reticular Dermis: An Underrecognized Histologic Phenomenon
McNiff J, Glusac E, Lazova R, Carroll C. Morphea Limited to the Superficial Reticular Dermis: An Underrecognized Histologic Phenomenon. American Journal Of Dermatopathology 1999, 21: 315-319. PMID: 10446770, DOI: 10.1097/00000372-199908000-00001.Peer-Reviewed Original ResearchConceptsLichen sclerosus et atrophicusSuperficial reticular dermisSuperficial dermisReticular dermisSpindle cellsDermal dendritic cellsCollagen bundlesTypical histologic featuresImmune accessory cellsSclerosus et atrophicusDermal spindle cellsCases of morpheaDeep reticular dermisElastic fibersDermal elastic fibersDendritic cellsHistologic featuresIndurated skinUnknown etiologyAdditional biopsiesEt atrophicusMorpheaHistologic phenomenonDeep dermisAccessory cells
1995
Pancreatoblastoma A Clinicopathologic Study and Review of the Literature
Klimstra D, Wenig B, Adair C, Heffess C. Pancreatoblastoma A Clinicopathologic Study and Review of the Literature. The American Journal Of Surgical Pathology 1995, 19: 1371-1389. PMID: 7503360, DOI: 10.1097/00000478-199512000-00005.Peer-Reviewed Original ResearchConceptsDied of tumorGood response to chemotherapyRare pancreatic tumorResponse to chemotherapyIncidental abdominal massCases of pancreatoblastomaPlump spindle cellsAbdominal massPancreatic tumorsObstructive jaundicePediatric patientsSquamoid corpusclesPediatric groupDuctal differentiationSpindle cellsAdult patientsSquamous appearanceIntracellular mucinCarcinoembryonic antigenDuctular formationAcinar differentiationTumorFemale casesPancreatoblastomaEpithelial cells
1991
Induction of different morphologic features of malignant melanoma and pigmented lesions after transformation of murine melanocytes with bFGF-cDNA and H-ras, myc, neu, and E1a oncogenes.
Ramon y Cajal S, Suster S, Halaban R, Filvaroff E, Dotto G. Induction of different morphologic features of malignant melanoma and pigmented lesions after transformation of murine melanocytes with bFGF-cDNA and H-ras, myc, neu, and E1a oncogenes. American Journal Of Pathology 1991, 138: 349-58. PMID: 1992762, PMCID: PMC1886204.Peer-Reviewed Original ResearchConceptsMalignant tumorsMorphologic featuresDifferent morphologic featuresMalignant melanomaBenign lesionsNude miceSyngenic miceSame tumorMelanocytic lesionsSmall round cellsBasic fibroblast growth factorH-RasFibroblast growth factorBenign melanocytic lesionsHistologic typeHistologic featuresSubcutaneous injectionBiologic behaviorSpindle cellsPossible molecular mechanismsEpithelioid cellsIntradermal nevusHuman melanomaLesionsDifferent tumors
1988
Pulmonary carcinomas with a sarcomatoid element: An immunocytochemical and ultrastructural analysis
Humphrey P, Scroggs M, Roggli V, Shelburne J. Pulmonary carcinomas with a sarcomatoid element: An immunocytochemical and ultrastructural analysis. Human Pathology 1988, 19: 155-165. PMID: 2449386, DOI: 10.1016/s0046-8177(88)80343-5.Peer-Reviewed Original ResearchConceptsSarcomatoid componentPulmonary carcinomaEpithelial differentiationSpindle cellsImmunocytochemical stainingSpindle cell populationSquamous cell carcinomaSpindle cell carcinomaSpindle cell componentUseful differentiating featureLight microscopyCell carcinomaPrimary carcinomaBiologic continuumBiphasic tumorSarcomatoid elementsUnusual neoplasmCarcinomaTumorsKeratin expressionUltrastructural examinationMesenchymal differentiationNeoplastic boneSharp demarcationUltrastructural analysis
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply