2025
Investigation of NPM1 mutation frequency in cutaneous blastic plasmacytoid dendritic cell neoplasms
Hamdan H, Siddon A, Ramia de Cap M, Germans S, Cantu M, Fuda F, Vandergriff T, Aggarwal N, Weinberg O. Investigation of NPM1 mutation frequency in cutaneous blastic plasmacytoid dendritic cell neoplasms. Human Pathology 2025, 158: 105766. PMID: 40216030, DOI: 10.1016/j.humpath.2025.105766.Peer-Reviewed Original ResearchConceptsBlastic plasmacytoid dendritic cell neoplasmBPDCN patientsBPDCN casesCutaneous blastic plasmacytoid dendritic cell neoplasmAcute myeloid leukemiaPlasmacytoid dendritic cell neoplasmDendritic cell neoplasmNPM1 mutationsMyeloid sarcomaCell neoplasmsSarcoma patientsImmunohistochemical stainingAbsence of NPM1 mutationsFrequency of NPM1 mutationsBone marrow of patientsLow white blood cell countCutaneous myeloid sarcomaWhite blood cell countMarrow of patientsTime of diagnosisHigher hemoglobin levelsBlood cell countPercentage of involvementSRSF2 mutationsComplex karyotype
2023
IRF8 may be a useful marker for blastic plasmacytoid dendritic cell neoplasm, especially with weak CD123 expression
Tang H, Panse G, Braddock D, Perincheri S, Xu M, McNiff J. IRF8 may be a useful marker for blastic plasmacytoid dendritic cell neoplasm, especially with weak CD123 expression. Journal Of Cutaneous Pathology 2023, 50: 595-600. PMID: 37082914, DOI: 10.1111/cup.14439.Peer-Reviewed Original ResearchConceptsBlastic plasmacytoid dendritic cell neoplasmPlasmacytoid dendritic cell neoplasmDendritic cell neoplasmPunch biopsy specimenBiopsy specimenCell neoplasmsCase of BPDCNUseful markerTumor cellsTCL-1 expressionAtypical mononuclear cellsBone marrow involvementDiffuse dermal infiltrateDendritic cell lineagePotential diagnostic pitfallRegulatory factor 8TCL-1BPDCN casesCD123 expressionMarrow involvementDermal infiltrateCutaneous nodulesMyelodysplastic syndromeSkin nodulesMononuclear cells
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