2021
α-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study
Lu SX, Huang YH, Liu LL, Zhang CZ, Yang X, Yang YZ, Shao CK, Li JM, Xie D, Zhang X, Jain D, Yun JP. α-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study. British Journal Of Cancer 2021, 124: 1988-1996. PMID: 33824478, PMCID: PMC8184895, DOI: 10.1038/s41416-021-01363-4.Peer-Reviewed Original ResearchConceptsHepatocellular carcinomaHepatocytic lesionsDiagnosis of HCCLiver biopsy cohortHepatocyte paraffin 1Independent retrospective cohortsBenign liver lesionsMulti-center studyGood diagnostic valueNovel diagnostic biomarkersArginase-1 (Arg-1) proteinsΑ-fetoprotein mRNASurgical cohortRetrospective cohortBiopsy cohortHepPar-1Arg-1Liver lesionsDiagnostic biomarkersDiagnostic valueMalignancy lesionsLesionsGlypican3CohortSpecific markers
2016
Distinct pathways of pathogenesis of intraductal oncocytic papillary neoplasms and intraductal papillary mucinous neoplasms of the pancreas
Basturk O, Chung S, Hruban R, Adsay N, Askan G, Iacobuzio-Donahue C, Balci S, Zee S, Memis B, Shia J, Klimstra D. Distinct pathways of pathogenesis of intraductal oncocytic papillary neoplasms and intraductal papillary mucinous neoplasms of the pancreas. Virchows Archiv 2016, 469: 523-532. PMID: 27591765, PMCID: PMC5083199, DOI: 10.1007/s00428-016-2014-x.Peer-Reviewed Original ResearchConceptsIntraductal papillary mucinous neoplasmIntraductal oncocytic papillary neoplasmPapillary mucinous neoplasmMucinous neoplasmsClaudin-4Papillary neoplasmDuctal adenocarcinomaB-catenin expressionExpression of mesothelinLesions expressed MUC5ACResults of immunolabelingNuclear p53 accumulationPancreatic ductal neoplasmsIntraductal componentSMAD4 lossHepPar-1Tumor typesDuctal neoplasmsGenetic alterationsMUC proteinsP53 accumulationNeoplasmsNeoplastic cellsDifferentiation markersMesothelinExpression of Markers of Hepatocellular Differentiation in Pancreatic Acinar Cell Neoplasms
Askan G, Deshpande V, Klimstra D, Adsay V, Sigel C, Shia J, Basturk O. Expression of Markers of Hepatocellular Differentiation in Pancreatic Acinar Cell Neoplasms. American Journal Of Clinical Pathology 2016, 146: 163-169. PMID: 27425386, PMCID: PMC5731433, DOI: 10.1093/ajcp/aqw096.Peer-Reviewed Original ResearchConceptsAcinar cell carcinomaMRNA in situ hybridizationAlbumin mRNA in situ hybridizationIn situ hybridizationGlypican-3Arginase 1Hepatocellular carcinomaMorphologic similarity to hepatocellular carcinomaHepatocyte paraffin antigen 1Marker of hepatocellular differentiationPancreatic acinar cell carcinomaExpressing arginase 1Acinar cell neoplasmsMessenger RNAAlbumin messenger RNARare tumorCell neoplasmsCell carcinomaHepPar-1Tissue microarrayDiagnostic challengeHepatocellular differentiationPancreatic neoplasmsA-fetoproteinDiagnostic value
2013
Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma
Krings G, Ramachandran R, Jain D, Wu TT, Yeh MM, Torbenson M, Kakar S. Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma. Modern Pathology 2013, 26: 782-791. PMID: 23348905, DOI: 10.1038/modpathol.2012.243.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, ScirrhousAdultAgedArginaseBile Duct NeoplasmsBile Ducts, IntrahepaticBiomarkers, TumorCarcinoma, HepatocellularChi-Square DistributionCholangiocarcinomaDiagnosis, DifferentialDiagnostic ErrorsFemaleGlypicansHumansImmunohistochemistryLiver NeoplasmsMaleMiddle AgedPredictive Value of TestsReproducibility of ResultsConceptsScirrhous hepatocellular carcinomaClassical hepatocellular carcinomaHepatocellular carcinomaHepatocellular carcinoma casesGlypican-3Carcinoma casesMarked stromal fibrosisEpithelial cell adhesion moleculeMetastatic adenocarcinomaIntrahepatic cholangiocarcinomaStromal fibrosisCytokeratin 7Needle biopsyFrequent positivityCell adhesion moleculeHepPar-1Immunohistochemical pitfallsMorphological subtypesCarcinomaAdenocarcinomaHepatocellular differentiationCytokeratin 19Erroneous diagnosisReliable markerAdhesion molecules
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