2023
Regulatory T cells in skin regeneration and wound healing
Knoedler S, Knoedler L, Kauke-Navarro M, Rinkevich Y, Hundeshagen G, Harhaus L, Kneser U, Pomahac B, Orgill D, Panayi A. Regulatory T cells in skin regeneration and wound healing. Military Medical Research 2023, 10: 49. PMID: 37867188, PMCID: PMC10591349, DOI: 10.1186/s40779-023-00484-6.Peer-Reviewed Original ResearchConceptsRegulatory T cellsT cellsRole of TregsIntegumentary systemNew treatment modalitiesTissue-resident cellsSubsequent wound healing processCutaneous wound healingExcessive inflammationImmune homeostasisTreatment modalitiesImmune cellsSkin adnexaWound healing processImmune responseTregsHealing processWound repairWound healingHealingEpidermal integrityCellsCollateral damageAdnexaInflammation
2019
Strategies for Leg Amputation in Patients with Charcot’s Arthropathy
Chen J, Sumpio B. Strategies for Leg Amputation in Patients with Charcot’s Arthropathy. 2019, 195-203. DOI: 10.1007/978-3-319-17918-6_16.Peer-Reviewed Original ResearchNegative pressure wound therapyCharcot arthropathyMajor lower extremity amputationChallenging disease processLower extremity amputationPressure wound therapyProper wound healingExtremity amputationLeg amputationWound healing processWound therapyDisease processAmputationArthropathyWound healingPatientsLimbSpecial considerationEdemaHypervascularityPathophysiologyTherapyTargeting Fibrotic Signaling: A Review of Current Literature and Identification of Future Therapeutic Targets to Improve Wound Healing.
Hetzler PT, Dash BC, Guo S, Hsia HC. Targeting Fibrotic Signaling: A Review of Current Literature and Identification of Future Therapeutic Targets to Improve Wound Healing. Annals Of Plastic Surgery 2019, 83: e92-e95. PMID: 31246672, PMCID: PMC6851445, DOI: 10.1097/sap.0000000000001955.Peer-Reviewed Original ResearchConceptsTherapeutic targetAberrant wound healing processAppropriate physiologic responseMorbid disease processSurvival of myofibroblastsWound healingFibrotic signaling pathwaysTranscription factor/serum response factor (MRTF/SRF) pathwayFuture therapeutic targetsSmooth muscle actinFuture translational researchCurrent literatureFibrotic signalingTherapeutic optionsFibrotic lesionsTissue injuryWound healing processDisease processPhysiologic responsesSerum response factor pathwayMuscle actinFactor pathwayExcessive responseFibrosisTranslational research
2014
Improved repair of dermal wounds in mice lacking microRNA‐155
van Solingen C, Araldi E, Chamorro‐Jorganes A, Fernández‐Hernando C, Suárez Y. Improved repair of dermal wounds in mice lacking microRNA‐155. Journal Of Cellular And Molecular Medicine 2014, 18: 1104-1112. PMID: 24636235, PMCID: PMC4112003, DOI: 10.1111/jcmm.12255.Peer-Reviewed Original ResearchConceptsMiR-155Wound tissueWound healingIncreased expressionWound closureImpaired wound repairAnalysis of woundsSkin of miceMiR-155 targetsType 1 collagenWild-type animalsInflammatory mediatorsWT miceWound healing processImmune responseInterleukin-4Healthy skinMicroRNA-155Punch woundsMiceElevated numbersBeneficial effectsWound closingDermal wound healingDermal wounds
2000
Accelerated Healing of Full-Thickness Skin Wounds in a Wet Environment
Svensjö T, Pomahac B, Yao F, Slama J, Eriksson E. Accelerated Healing of Full-Thickness Skin Wounds in a Wet Environment. Plastic & Reconstructive Surgery 2000, 106: 602-612. DOI: 10.1097/00006534-200009030-00012.Peer-Reviewed Original ResearchFull-thickness skin woundsSkin woundsAccelerated healingSaline-treated woundsGranulation tissue formationYoung Yorkshire pigsSecondary intentionTreatment modalitiesWound healing processSkin wound repairGranulation tissueWound healing modelWound contractionStandardized fashionPorcine wound healing modelFast contractionHealing processWound repairWoundsCell layerYorkshire pigsMoist woundSkin repairHealing modelHealingAccelerated Healing of Full-Thickness Skin Wounds in a Wet Environment
Svensjö T, Pomahac B, Yao F, Slama J, Eriksson E. Accelerated Healing of Full-Thickness Skin Wounds in a Wet Environment. Plastic & Reconstructive Surgery 2000, 106: 602-612. PMID: 10987467, DOI: 10.1097/00006534-200009010-00012.Peer-Reviewed Original ResearchConceptsFull-thickness skin woundsSkin woundsAccelerated healingSaline-treated woundsGranulation tissue formationYoung Yorkshire pigsSecondary intentionTreatment modalitiesWound healing processSkin wound repairGranulation tissueWound healing modelWound contractionStandardized fashionPorcine wound healing modelFast contractionHealing processWound repairWoundsCell layerYorkshire pigsMoist woundSkin repairHealing modelHealing
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