2024
Foxp3+ regulatory T cells reside within the corneal epithelium and co-localize with limbal stem cells
Tahvildari M, Me R, Setia M, Gao N, Suvas P, McClellan S, Suvas S. Foxp3+ regulatory T cells reside within the corneal epithelium and co-localize with limbal stem cells. Experimental Eye Research 2024, 249: 110123. PMID: 39396695, PMCID: PMC11622170, DOI: 10.1016/j.exer.2024.110123.Peer-Reviewed Original ResearchConceptsLimbal stem cellsRegulatory T cellsResident TregsT cellsFoxp3<sup>+</sup> regulatory T cellsLimbal stem cell functionMouse modelCorneal epithelial wound healingModel of mechanical injuryStem cellsDepletion of TregsCell functionEpithelial wound healingEpithelial cell functionWound healingStem cell functionMechanical injuryAnti-CD25Epithelial healingSubconjunctival injectionCorneal epitheliumCorneal stromaTregsCornealCornea
2019
Minimally Invasive Corneal Neurotization With Acellular Nerve Allograft
Leyngold I, Yen M, Tian J, Leyngold M, Vora G, Weller C. Minimally Invasive Corneal Neurotization With Acellular Nerve Allograft. Ophthalmic Plastic And Reconstructive Surgery 2019, Publish Ahead of Print: &na;. PMID: 30059392, DOI: 10.1097/iop.0000000000001181.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAllograftsChildCorneaCorneal DiseasesFemaleFollow-Up StudiesHumansMaleMicroscopy, ConfocalMiddle AgedMinimally Invasive Surgical ProceduresNerve RegenerationNerve TransferOphthalmic NerveOphthalmologic Surgical ProceduresRetrospective StudiesTreatment OutcomeYoung AdultConceptsAcellular nerve allograftsNerve allograftsCorneal neurotizationCorneal sensibilityVivo confocal microscopyInvasive surgical techniquesCorneal epithelial integrityNeurotrophic keratopathyAffected eyeNerve densityClinical outcomesInfraorbital nerveVisual acuityNerve pediclesSurgical techniqueInvasive approachOcular surfaceRetrospective evaluationAllograftsTransconjunctival approachCorneal stromaNeurotizationPatientsEpithelial integrityMonths
2017
Nitrogen mustard-induced corneal injury involves the sphingomyelin-ceramide pathway
Charkoftaki G, Jester JV, Thompson DC, Vasiliou V. Nitrogen mustard-induced corneal injury involves the sphingomyelin-ceramide pathway. The Ocular Surface 2017, 16: 154-162. PMID: 29129753, PMCID: PMC7376578, DOI: 10.1016/j.jtos.2017.11.004.Peer-Reviewed Original ResearchConceptsCorneal damageNM exposureSphingomyelin-ceramide pathwayCorneal stromaIrreversible corneal damageNitrogen mustardAltered lipid profileSulfur mustardCorneal injuryLipid profileCentral corneaCorneal epitheliumRabbit eyesSpecific sphingomyelinsPotent vesicantCorneaOrgan cultureStromaLipidomic analysisExposureMorphological changesDamaging effectsDamageInjuryPathway
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