2022
Lung Injury Induces Alveolar Type 2 Cell Hypertrophy and Polyploidy with Implications for Repair and Regeneration.
Weng A, Maciel Herrerias M, Watanabe S, Welch LC, Flozak AS, Grant RA, Aillon RP, Dada LA, Han SH, Hinchcliff M, Misharin AV, Budinger GRS, Gottardi CJ. Lung Injury Induces Alveolar Type 2 Cell Hypertrophy and Polyploidy with Implications for Repair and Regeneration. American Journal Of Respiratory Cell And Molecular Biology 2022, 66: 564-576. PMID: 35202558, PMCID: PMC9116356, DOI: 10.1165/rcmb.2021-0356oc.Peer-Reviewed Original ResearchConceptsLung injuryCell hypertrophyAT2 cellsAlveolar epithelial injuryIntegrated stress responseDistal lung epitheliumBleomycin injuryEpithelial injuryLung epitheliumInjuryBarrier restorationHypertrophic growthSmall molecule ISRIBWound healingFacultative progenitorsHypertrophyStress responseAT2BinucleationCellsReinjuryShort termEpitheliumResponse
2010
Interference with Intraepithelial TNF-α Signaling Inhibits CD8+ T-Cell-Mediated Lung Injury in Influenza Infection
Srikiatkhachorn A, Chintapalli J, Liu J, Jamaluddin M, Harrod K, Whitsett J, Enelow R, Ramana C. Interference with Intraepithelial TNF-α Signaling Inhibits CD8+ T-Cell-Mediated Lung Injury in Influenza Infection. Viral Immunology 2010, 23: 639-645. PMID: 21142450, PMCID: PMC2991178, DOI: 10.1089/vim.2010.0076.Peer-Reviewed Original ResearchConceptsRespiratory virus infectionsNF-kB activationLung injuryT cell-mediated immunopathologyCD8(+) T cell recognitionVirus infectionSevere influenza pneumoniaEffector T cellsP65 subunit of NF-kBNF-kBP65 subunitAirway epithelial expressionDistal lung epitheliumEpithelial chemokine productionT cell antigen recognitionTNF-a expressionInhibition of NF-kB activationT cell recognitionInfluenza infectionInfluenza pneumoniaPhosphorylation of AktEpithelial expressionPulmonary immunopathologyT cellsChemokine expression
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply