2024
Nephrotoxicity of Lithium and Drugs of Abuse
Neugarten J, Neugarten S, Golestaneh L. Nephrotoxicity of Lithium and Drugs of Abuse. 2024 DOI: 10.1016/b978-0-323-95488-4.00075-9.Peer-Reviewed Original ResearchAdvanced renal failureSerum lithium levelsRenal failureLithium therapyDevelopment of advanced renal failureElevated serum lithium levelsSusceptible subgroup of patientsLithium levelsImpaired urinary concentrating abilityImpaired concentrating abilityConcentrating abilityTherapeutic serum lithium levelsAcute interstitial nephritisEpidemiology of renal diseasesLithium-treated patientsRisk of nephrotoxicityProgressive renal failureSubgroup of patientsGlomerular filtration rateUrinary concentrating abilityAcute tubular necrosisMaintenance lithium therapyDecades of treatmentDrugs of abuseChronic tubulointerstitial injury
2023
Nonpodocyte Roles of APOL1 Variants: An Evolving Paradigm
Pell J, Nagata S, Menon M. Nonpodocyte Roles of APOL1 Variants: An Evolving Paradigm. Kidney360 2023, 4: e1325-e1331. PMID: 37461136, PMCID: PMC10550003, DOI: 10.34067/kid.0000000000000216.Peer-Reviewed Original ResearchConceptsApolipoprotein L1Progressive renal failureAPOL1 risk variantsImmune response genesParadigm of diseasesMechanisms of diseaseRenal failureKidney diseaseBody of evidenceImmune cellsClinical dataRecent African ancestryRisk genotypesAPOL1 variantsDiseaseEndothelial cellsPutative signaling pathwaysGenetic factorsSeminal dataPhenotype progressionCausal rolePodocytesRisk variantsSignaling pathwaysEvolving Paradigm
2019
Poor allograft outcome in Indian patients with post-transplant C3 glomerulopathy
Kumar A, Ramachandran R, Rawat A, Das R, Rayat C, Kenwar D, Sharma A, Gupta K, Nada R. Poor allograft outcome in Indian patients with post-transplant C3 glomerulopathy. Clinical Kidney Journal 2019, 14: 291-300. PMID: 33564431, PMCID: PMC7857824, DOI: 10.1093/ckj/sfz135.Peer-Reviewed Original ResearchAutoantibodies to complement factor HComplement factor HComplement factor BAlternative complement pathwayCases of C3GC3G patientsComplement 3 glomerulopathyPost-transplant recurrenceRenal allograft biopsiesMonths of transplantationProgressive renal failureSerum complement levelsPoor allograft outcomesSerum CFH levelsC3 nephritic factorAllograft dysfunctionThrombotic microangiopathyAllograft outcomesGraft dysfunctionGraft lossG patientsRenal dysfunctionGenetic workupRecurrent casesRenal failure
2018
Nephrotoxicity of Lithium and Drugs of Abuse☆
Neugarten J, Friedman B, Golestaneh L. Nephrotoxicity of Lithium and Drugs of Abuse☆. 2018, 304-339. DOI: 10.1016/b978-0-12-801238-3.02057-2.Peer-Reviewed Original ResearchAdvanced renal failureSerum lithium levelsRenal failureLithium therapyDevelopment of advanced renal failureElevated serum lithium levelsSusceptible subgroup of patientsLithium levelsImpaired urinary concentrating abilityImpaired concentrating abilityTherapeutic serum lithium levelsConcentrating abilityLithium-treated patientsRisk of nephrotoxicitySubgroup of patientsProgressive renal failureGlomerular filtration rateUrinary concentrating abilityMaintenance lithium therapyDecades of treatmentDrugs of abuseTubulo-interstitial injuryLithium-induced nephrotoxicityRenal functionSerum levels
2017
Circulating Monoclonal IgG1-kappa Antibodies Causing Anti-glomerular Basement Membrane Nephritis
Vankalakunti M, Nada R, Kumar A, Patro K, Ramakrishnan S, Rangarajan D. Circulating Monoclonal IgG1-kappa Antibodies Causing Anti-glomerular Basement Membrane Nephritis. Indian Journal Of Nephrology 2017, 27: 327-329. PMID: 28761240, PMCID: PMC5514834, DOI: 10.4103/ijn.ijn_113_16.Peer-Reviewed Original ResearchLife-threatening pulmonary hemorrhageAnti-glomerular basement membraneProgressive renal failureMode of therapyRare monoclonal antibodiesAnti-GBM antibodiesAnti-GBM nephritisWell-characterized causesCause of glomerulonephritisAntibody diseasePulmonary hemorrhageRenal failureGlomerular capillary wallRenal damageEarly diagnosisMonoclonal antibodiesBasement membraneAntibodiesCapillary wallHemoptysisImmunosuppressionPlasmapheresisHemorrhageGlomerulonephritisNephritis
2016
Oxalate, inflammasome, and progression of kidney disease
Ermer T, Eckardt KU, Aronson PS, Knauf F. Oxalate, inflammasome, and progression of kidney disease. Current Opinion In Nephrology & Hypertension 2016, 25: 363-371. PMID: 27191349, PMCID: PMC4891250, DOI: 10.1097/mnh.0000000000000229.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsChronic kidney diseaseProgressive renal failureRenal inflammationRenal failurePlasma oxalateKidney diseaseInflammasome activationElevated plasma oxalate levelsNOD-like receptor familyProgressive renal damageGlomerular filtration rateMore rapid progressionWarrants clinical trialsPlasma oxalate levelsRenal damageEnteric hyperoxaluriaMacrophage infiltrationIL-1βFiltration rateClinical trialsRapid progressionInflammasome proteinsMice protectsUrinary oxalatePyrin domain
2015
IgG4‐related tubulointerstitial nephritis: A prospective analysis
Nada R, Ramachandran R, Kumar A, Rathi M, Rawat A, Joshi K, Kohli H, Gupta K. IgG4‐related tubulointerstitial nephritis: A prospective analysis. International Journal Of Rheumatic Diseases 2015, 19: 721-729. PMID: 26355389, DOI: 10.1111/1756-185x.12675.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAutoimmune DiseasesBiomarkersBiopsyDisease ProgressionFemaleFollow-Up StudiesGlomerulonephritis, MembranousHumansImmunoglobulin GImmunohistochemistryImmunosuppressive AgentsIndiaKidneyKidney Failure, ChronicMaleMiddle AgedNephritis, InterstitialProspective StudiesProteinuriaRemission InductionTime FactorsTreatment OutcomeYoung AdultConceptsEnd stage renal diseaseStage renal diseaseRenal diseaseFollow-upSteroid therapyRenal dysfunctionExtra-renal organ involvementIgG4-related systemic diseaseSerum IgG4 levelsProgressive chronic kidney diseaseEnd-stage renal diseaseExtra-renal manifestationsFocal renal massesProgressive renal failurePattern CTubulo-interstitial nephritisProspective Follow-upChronic kidney diseaseImmunosuppressive therapyAggressive courseIgG4 levelsHistological diagnosisRenal massesSerum creatinineOrgan involvement
2013
NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy
Knauf F, Asplin JR, Granja I, Schmidt IM, Moeckel GW, David RJ, Flavell RA, Aronson PS. NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy. Kidney International 2013, 84: 895-901. PMID: 23739234, PMCID: PMC3772982, DOI: 10.1038/ki.2013.207.Peer-Reviewed Original ResearchConceptsProgressive renal failureRenal failureCalcium oxalate crystal depositionCrystal-associated diseasesOverproduction of oxalateWild-type miceHigh-oxalate dietNephropathy resultsOxalate nephropathyRenal histologyKidney diseaseOxalate dietInflammatory responseNALP3 expressionDietary oxalateIntestinal oxalateOxalate homeostasisSoluble oxalateNephropathyCrystal depositionMiceMultiple disordersNALP3DietInflammation
2010
7.17 Nephrotoxicity of Lithium and Drugs of Abuse
Neugarten J, Golestaneh L. 7.17 Nephrotoxicity of Lithium and Drugs of Abuse. 2010, 405-431. DOI: 10.1016/b978-0-08-046884-6.00822-8.Peer-Reviewed Original ResearchAdvanced renal failureSerum lithium levelsRenal failureLithium therapyDevelopment of advanced renal failureElevated serum lithium levelsSusceptible subgroup of patientsLithium levelsImpaired urinary concentrating abilityImpaired concentrating abilityConcentrating abilityTherapeutic serum lithium levelsLithium-treated patientsRisk of nephrotoxicityProgressive renal failureSubgroup of patientsGlomerular filtration rateUrinary concentrating abilityMaintenance lithium therapyDecades of treatmentDrugs of abuseTubulo-interstitial injuryLithium-induced nephrotoxicityRenal functionSerum levels
2006
Catastrophic antiphospholipid syndrome in a 7-year-old girl
Park J, Shin J, Shin Y, Kim D, Lee J, Kim M, Lee S, Lee D. Catastrophic antiphospholipid syndrome in a 7-year-old girl. Clinical Rheumatology 2006, 26: 1011-1013. PMID: 16598412, DOI: 10.1007/s10067-006-0251-0.Peer-Reviewed Original ResearchConceptsAntiphospholipid syndromeCatastrophic antiphospholipid syndromeRecognition of Antiphospholipid SyndromeProgressive renal failureSystemic lupus erythematosusLife-threatening conditionMagnetic resonance imagingRenal involvementMultiorgan failureRenal cortical infarctsThrombotic episodesRenal failureLupus erythematosusFavorable outcomeVascular thrombosisSystemic diseaseEarly recognitionDisease progressionCortical infarctionResonance imagingSyndromeMultiple organsThrombosisPatientsDisease
2002
Renal artery stenosis: A cardiovascular perspective
Vashist A, Heller E, Brown E, Alhaddad I. Renal artery stenosis: A cardiovascular perspective. American Heart Journal 2002, 143: 559-564. PMID: 11923791, DOI: 10.1067/mhj.2002.120769.Peer-Reviewed Original ResearchConceptsRenal artery stenosisRevascularization strategyRenal arteryManagement of RASAggressive risk factor modificationAtherosclerotic renal artery stenosisPercutaneous transluminal angioplasty techniquesAppropriate revascularization strategyRisk factor modificationDiagnosis of RASCongestive heart failureImportant clinical entityProgressive renal failureEffective revascularization strategyNoninvasive screening testSeverity of stenosisMagnetic resonance angiographyTraditional surgical proceduresGeneralized atherosclerosisUncontrolled hypertensionAntiplatelet therapyFibromuscular dysplasiaPatient's hypertensionRenal insufficiencyRenovascular hypertension
1986
Progressive tubulointerstitial renal disease in infancy with associated hepatic abnormalities
Harris H, Carpenter T, Shanley P, Rosen S, Levey R, Harmon W. Progressive tubulointerstitial renal disease in infancy with associated hepatic abnormalities. The American Journal Of Medicine 1986, 81: 169-176. PMID: 3524222, DOI: 10.1016/0002-9343(86)90205-6.Peer-Reviewed Original ResearchConceptsHepatic abnormalitiesInfantile polycystic kidney diseaseSignificant renal insufficiencyTubulointerstitial renal diseaseBile duct proliferationProgressive renal failurePolycystic kidney diseaseRenal Fanconi syndromeRenal insufficiencyRenal transplantTubulointerstitial injuryPortal fibrosisRenal failureRenal diseaseDuct proliferationClinical evidenceFat malabsorptionRenal lesionsKidney diseaseHepatic fibrosisMale infantRenal disordersFanconi syndromeMorphologic featuresDiagnostic categories
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