2024
Toxic Nephropathies of the Tubulointerstitium: Core Curriculum 2024
Krishnan N, Moledina D, Perazella M. Toxic Nephropathies of the Tubulointerstitium: Core Curriculum 2024. American Journal Of Kidney Diseases 2024, 83: 659-676. PMID: 38243994, DOI: 10.1053/j.ajkd.2023.09.017.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsRenal injurySeverity of renal injuryToxic nephropathyTubulointerstitial renal injuryIrreversible renal injuryToxin-induced renal injuryImmune response genesNephrotoxic riskClinical presentationTubulointerstitial injuryRenal functionClinical manifestationsPatient characteristicsTubular secretionGlomerular filtrationComorbid conditionsMetabolic handlingDrug metabolismExcretory pathwayInjuryTransport defectAdverse effectsTubulointerstitiumNephropathyExogenous toxins
2023
Nonpodocyte Roles of APOL1 Variants: An Evolving Paradigm
Pell J, Nagata S, Menon M. Nonpodocyte Roles of APOL1 Variants: An Evolving Paradigm. Kidney360 2023, 4: e1325-e1331. PMID: 37461136, PMCID: PMC10550003, DOI: 10.34067/kid.0000000000000216.Peer-Reviewed Original ResearchConceptsApolipoprotein L1Progressive renal failureAPOL1 risk variantsImmune response genesParadigm of diseasesMechanisms of diseaseRenal failureKidney diseaseBody of evidenceImmune cellsClinical dataRecent African ancestryRisk genotypesAPOL1 variantsDiseaseEndothelial cellsPutative signaling pathwaysGenetic factorsSeminal dataPhenotype progressionCausal rolePodocytesRisk variantsSignaling pathwaysEvolving Paradigm
2022
The Prostate Cancer Androgen Receptor Cistrome in African American Men Associates with Upregulation of Lipid Metabolism and Immune Response
Berchuck J, Adib E, Alaiwi S, Dash A, Shin J, Lowder D, McColl C, Castro P, Carelli R, Benedetti E, Deng J, Robertson M, Baca S, Bell C, McClure H, Zarif T, Davidsohn M, Lakshminarayanan G, Rizwan K, Skapura D, Grimm S, Davis C, Ehli E, Kelleher K, Seo J, Mitsiades N, Coarfa C, Pomerantz M, Loda M, Ittmann M, Freedman M, Kaochar S. The Prostate Cancer Androgen Receptor Cistrome in African American Men Associates with Upregulation of Lipid Metabolism and Immune Response. Cancer Research 2022, 82: 2848-2859. PMID: 35731919, PMCID: PMC9379363, DOI: 10.1158/0008-5472.can-21-3552.Peer-Reviewed Original ResearchConceptsProstate cancerImmune responseProstate tumorsAndrogen receptorAggressiveness of prostate cancerLipid metabolismAA prostate tumorsPrimary prostate tumorsProstate cancer cohortProstate cancer progressionAA prostate cancerIncreased androgen signalingEA prostate cancerLevels of lipid metabolismImmune response genesAR cistromeUpregulation of lipid metabolismAndrogen signalingPoor prognosisClinical developmentLipid metabolism gene expressionMetabolomics dataCancer cohortProstateInhibitors of metabolic enzymesGut Microbiota and Immune Modulatory Properties of Human Breast Milk Streptococcus salivarius and S. parasanguinis Strains
Li S, Li N, Wang C, Zhao Y, Cao J, Li X, Zhang Z, Li Y, Yang X, Wang X, Che C, Zhao Y, Wang L, Zhao L, Shen J. Gut Microbiota and Immune Modulatory Properties of Human Breast Milk Streptococcus salivarius and S. parasanguinis Strains. Frontiers In Nutrition 2022, 9: 798403. PMID: 35273986, PMCID: PMC8901577, DOI: 10.3389/fnut.2022.798403.Peer-Reviewed Original ResearchImmune-modulatory propertiesHuman breast milkGut microbiotaBreast milkModulatory propertiesAnti-inflammatory Treg cellsHuman peripheral blood mononuclear cellsPeripheral blood mononuclear cellsIleal mRNA expressionBlood mononuclear cellsT helper cellsAnti-inflammatory potentialPostnatal week 3Postnatal day 1Microbiota α-diversityImmune response genesTreg cellsBreast feedingHelper cellsMononuclear cellsIleal expressionSuckling miceGut immunityWeaning miceInfant gutOxidative stress induces inflammation of lens cells and triggers immune surveillance of ocular tissues
Thompson B, Davidson EA, Chen Y, Orlicky DJ, Thompson DC, Vasiliou V. Oxidative stress induces inflammation of lens cells and triggers immune surveillance of ocular tissues. Chemico-Biological Interactions 2022, 355: 109804. PMID: 35123994, PMCID: PMC9136680, DOI: 10.1016/j.cbi.2022.109804.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcysteineAnimalsButhionine SulfoximineCell LineChemokine CCL7CytokinesDown-RegulationEpithelial CellsEpithelial-Mesenchymal TransitionEyeGlutamate-Cysteine LigaseImmunity, InnateLens, CrystallineLeukocytesMiceMice, Inbred C57BLMice, KnockoutOxidative StressReactive Oxygen SpeciesUp-RegulationConceptsPosterior capsule opacificationCytokine expressionKO miceImmune surveillanceOxidative stressLens epithelial cellsOcular structuresLens cellsDevelopment of PCOEpithelial cellsInnate immune cellsExpression of cytokinesEx vivo inductionOcular surface tissuesExpression of markersImmune response genesCON miceControl miceCapsule opacificationImmune cellsPostnatal dayΑ-SMAMouse modelOcular tissuesVivo induction
2021
Impaired GSH biosynthesis disrupts eye development, lens morphogenesis and PAX6 function
Thompson B, Chen Y, Davidson EA, Garcia-Milian R, Golla JP, Apostolopoulos N, Orlicky DJ, Schey K, Thompson DC, Vasiliou V. Impaired GSH biosynthesis disrupts eye development, lens morphogenesis and PAX6 function. The Ocular Surface 2021, 22: 190-203. PMID: 34425299, PMCID: PMC8560581, DOI: 10.1016/j.jtos.2021.08.010.Peer-Reviewed Original ResearchConceptsHEK293T cellsEye developmentGSH biosynthesisTransactivation activityPax6 functionReactive oxygen speciesSubsequent gene ontologyCell identity genesButhionine sulfoximineEpithelial cell identityRNA-seq analysisIngenuity Pathway AnalysisKey upstream regulatorIdentity genesCell identityGene OntologyRNA-seqImmune response genesBioinformatics analysisResponse genesGlutathione biosynthesisLens morphogenesisMolecular consequencesUpstream regulatorMicrophthalmia phenotypeA meta-study on transcription factor networks in the suicidal brain
Cabrera-Mendoza B, de Anda-Jáuregui G, Nicolini H, Fresno C. A meta-study on transcription factor networks in the suicidal brain. Journal Of Psychiatric Research 2021, 136: 23-31. PMID: 33548827, DOI: 10.1016/j.jpsychires.2021.01.037.Peer-Reviewed Original ResearchConceptsBipolar disorderSchizophrenia NetworkSuicidal brainDifferent mental disordersDisorders NetworkMajor depression disorderImmune response genesGene expression differencesHealthy controlsImmune responseDepression disorderDepression networkDisorder-specific characteristicsMental disordersPrefrontal cortexDisordersExpression differencesRegulatory mechanismsTranscription factor networkSuicideSocial stressBrainSuicide neurobiologyTranscriptional factorsFactor network
2020
Zika Virus-Infected Decidual Cells Elicit a Gestational Age-Dependent Innate Immune Response and Exaggerate Trophoblast Zika Permissiveness: Implication for Vertical Transmission.
Guzeloglu-Kayisli O, Guo X, Tang Z, Semerci N, Ozmen A, Larsen K, Mutluay D, Guller S, Schatz F, Kayisli UA, Lockwood CJ. Zika Virus-Infected Decidual Cells Elicit a Gestational Age-Dependent Innate Immune Response and Exaggerate Trophoblast Zika Permissiveness: Implication for Vertical Transmission. The Journal Of Immunology 2020, 205: 3083-3094. PMID: 33139490, DOI: 10.4049/jimmunol.2000713.Peer-Reviewed Original ResearchConceptsHuman decidual cellsDecidual cellsZika virusViral attachment factorsTerm decidual stromal cellsVertical transmissionDecidual cell supernatantsTerm decidual cellsInnate immune response genesInnate immune responsivenessExact pathogenic mechanismDecidual stromal cellsHuman first trimesterInnate immune responseSevere fetal defectsImmune response genesFetal sequelaeGestational ageFirst trimesterPlacental transmissionZIKV infectionCytotrophoblast culturesImmune responsivenessZika infectionLate pregnancyProfiles of Local and Systemic Inflammation in the Outcome of Treatment of Human Cutaneous Leishmaniasis Caused by Leishmania (Viannia)
Navas A, Fernández O, Gallego-Marín C, del Mar Castro M, Rosales-Chilama M, Murillo J, Cossio A, McMahon-Pratt D, Saravia N, Gómez MA. Profiles of Local and Systemic Inflammation in the Outcome of Treatment of Human Cutaneous Leishmaniasis Caused by Leishmania (Viannia). Infection And Immunity 2020, 88: 10.1128/iai.00764-19. PMID: 31818959, PMCID: PMC7035935, DOI: 10.1128/iai.00764-19.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsOutcome of treatmentInnate immune responseCutaneous leishmaniasisTreatment failureCL patientsBiopsy specimensImmune responseResponse of PBMCLocal innate immune responseTreatment of CLBlood mononuclear cellsEnd of treatmentLesion biopsy specimensHuman cutaneous leishmaniasisEfficacy of treatmentGene expression profilesImmune response genesImmune correlatesClinical cureSystemic inflammationPretreatment expressionMeglumine antimoniateMononuclear cellsCare treatment
2018
Region-specific innate antiviral responses of the human epididymis
Browne JA, Leir SH, Eggener SE, Harris A. Region-specific innate antiviral responses of the human epididymis. Molecular And Cellular Endocrinology 2018, 473: 72-78. PMID: 29339104, PMCID: PMC6045438, DOI: 10.1016/j.mce.2018.01.004.Peer-Reviewed Original ResearchConceptsHEE cellsToll-like receptor 3Innate immune response genesRetinoic acid-inducible gene IAcid-inducible gene IType I interferonIFN-β mRNA expressionInnate antiviral responseImmune response genesIFN-β secretionHuman epididymisAntiviral response pathwaysLike receptorsImpairs fertilityCauda regionsI interferonViral infectionAntiviral responseReceptor 3MRNA expressionEpithelial cellsNuclear translocationGene IEnhanced responseHuman epididymis epithelial cells
2016
Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus
Yao J, Leng L, Sauler M, Fu W, Zheng J, Zhang Y, Du X, Yu X, Lee P, Bucala R. Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus. Journal Of Clinical Investigation 2016, 126: 732-744. PMID: 26752645, PMCID: PMC4731159, DOI: 10.1172/jci81937.Peer-Reviewed Original ResearchMeSH KeywordsArthritis, RheumatoidCCAAT-Enhancer-Binding ProteinsGenetic LociGenetic Predisposition to DiseaseHumansIntramolecular OxidoreductasesJurkat CellsMacrophage Migration-Inhibitory FactorsMicrosatellite RepeatsPolymorphism, GeneticPromoter Regions, GeneticTranscription, GeneticUbiquitin-Protein LigasesConceptsTranscription factorsMacrophage migration inhibitory factorWhole-genome transcription analysisOligonucleotide affinity chromatographyLength-dependent mannerTranscriptional regulationFunctional insightsTranscription analysisNuclear proteinsImmune response genesPolymorphic lociMIF promoterResponse genesNuclear lysatesKey regulatorHigher mRNA levelsMajor proteinsSusceptibility lociTranscriptionCytokine macrophage migration inhibitory factorLociExpression levelsCommon allelesMigration inhibitory factorMicrosatellite polymorphism
2014
Transcriptional profiling of the spleen in progressive visceral leishmaniasis reveals mixed expression of type 1 and type 2 cytokine-responsive genes
Espitia CM, Saldarriaga OA, Travi BL, Osorio EY, Hernandez A, Band M, Patel MJ, Medina AA, Cappello M, Pekosz A, Melby PC. Transcriptional profiling of the spleen in progressive visceral leishmaniasis reveals mixed expression of type 1 and type 2 cytokine-responsive genes. BMC Immunology 2014, 15: 38. PMID: 25424735, PMCID: PMC4253007, DOI: 10.1186/s12865-014-0038-z.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCluster AnalysisCricetinaeCytokinesDisease ProgressionDNA, ComplementaryExpressed Sequence TagsGene Expression ProfilingGene Expression RegulationGene OntologyHumansInterferon-gammaLeishmania donovaniLeishmaniasis, VisceralMesocricetusMolecular Sequence AnnotationOligonucleotide Array Sequence AnalysisPrincipal Component AnalysisRNA, MessengerSignal TransductionSpleenUp-RegulationConceptsSyrian golden hamstersVisceral leishmaniasisHamster modelGolden hamstersProgressive visceral leishmaniasisIL-4/ILIFN-γ responsesAlternative macrophage activationProgression of diseaseStudy of immunopathogenesisHamster infection modelPolarization of macrophagesImmune cell traffickingImmune response genesImmune-related genesSpleen responseImmunopathological featuresMassive splenomegalyInfected groupMacrophage activationIntracellular protozoanCell traffickingType 1Infection modelLeishmaniasis
2000
Innate immune recognition: mechanisms and pathways
Medzhitov R, Janeway C. Innate immune recognition: mechanisms and pathways. Immunological Reviews 2000, 173: 89-97. PMID: 10719670, DOI: 10.1034/j.1600-065x.2000.917309.x.Peer-Reviewed Original ResearchConceptsPattern recognition receptorsInnate immune systemMost multicellular organismsRecognition receptorsMulticellular organismsHost defenseInducible responsesImmune response genesResponse genesPathogen recognitionImmune systemMolecular patternsInfectious microbesAncient formPathwayReceptorsDefenseGenesMicrobesOrganismsMicroorganismsLarge groupPathogensExpressionPatterns
1999
The Toll-receptor family and control of innate immunity
Kopp E, Medzhitov R. The Toll-receptor family and control of innate immunity. Current Opinion In Immunology 1999, 11: 13-18. PMID: 10047546, DOI: 10.1016/s0952-7915(99)80003-x.Peer-Reviewed Original ResearchConceptsInducible immune response genesToll receptor familyToll receptorTransduction pathwaysImmune response genesHost defense systemInnate immune recognitionMicrobial pathogensGermline-encoded receptorsNuclear factor-kappaBMolecular patternsDefense systemInnate immunityFactor-kappaBImmune recognitionPathwayReceptorsInsectsMammalsGenesPlantsPathogensExpressionKappaBFamily
1998
MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways
Medzhitov R, Preston-Hurlburt P, Kopp E, Stadlen A, Chen C, Ghosh S, Janeway C. MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways. Molecular Cell 1998, 2: 253-258. PMID: 9734363, DOI: 10.1016/s1097-2765(00)80136-7.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAntigens, DifferentiationDrosophilaDrosophila ProteinsHumansInterleukin-1 Receptor-Associated KinasesMembrane GlycoproteinsMembrane ProteinsMyeloid Differentiation Factor 88NF-kappa BProtein KinasesProteinsReceptors, Cell SurfaceReceptors, ImmunologicReceptors, Interleukin-1Signal TransductionTNF Receptor-Associated Factor 6Toll-Like ReceptorsTranscription Factor AP-1ConceptsIL-1R familyNF-kappaB activationNF-kappaB pathwayImmune response genesToll/IL-1R familyAP-1 activationImmune responseIL-1RTRAF6 proteinInnate immunityNF-kappaBMyD88Drosophila Toll proteinReceptor familyToll receptorAdaptor proteinSignaling pathwaysReceptorsActivationToll proteinRegulator moleculesResponse genesAdult DrosophilaPathwayProtein
1991
Gamma-interferon induces differential expression of HLA-DR, -DP and -DQ in human ciliary epithelial cells
Helbig H, Kittredge K, Palestine A, Coca-Prados M, Nussenblatt R. Gamma-interferon induces differential expression of HLA-DR, -DP and -DQ in human ciliary epithelial cells. Graefe's Archive For Clinical And Experimental Ophthalmology 1991, 229: 191-194. PMID: 1904385, DOI: 10.1007/bf00170556.Peer-Reviewed Original ResearchConceptsMHC-II expressionHLA-DRGamma-IFNHLA-DQCiliary epithelial cellsGamma interferonOcular cellsClass IIMajor histocompatibility complex class IIBone marrow-derived cellsHistocompatibility complex class IICiliary epitheliumImmune suppressor genesEpithelial cellsHuman non-pigmented ciliary epithelial cellsAntigen-specific activationT helper lymphocytesMarrow-derived cellsCultured human non-pigmented ciliary epithelial cellsMHC class IIMeans of immunohistochemistryPresentation of antigensHuman MHC IIHuman ciliary epithelial cellsImmune response genes
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