2022
Hematopoietic Cell Transplantation for Congenital Dyserythropoietic Anemia: A Report from the Pediatric Transplant and Cellular Therapy Consortium
Rangarajan HG, Stanek JR, Abdel-Azim H, Modi A, Haight A, McKinney CM, McKeone DJ, Buchbinder DK, Katsanis E, Abusin GA, Ahmed I, Law J, Silva JG, Mallhi KK, Burroughs LM, Shah N, Shaw PJ, Greiner R, Shenoy S, Pulsipher MA, Abu-Arja R. Hematopoietic Cell Transplantation for Congenital Dyserythropoietic Anemia: A Report from the Pediatric Transplant and Cellular Therapy Consortium. Transplantation And Cellular Therapy 2022, 28: 329.e1-329.e9. PMID: 35288346, DOI: 10.1016/j.jtct.2022.03.007.Peer-Reviewed Original ResearchConceptsHematopoietic cell transplantationEvent-free survivalCongenital dyserythropoietic anemiaCell transplantationAllogeneic hematopoietic cell transplantationSecond hematopoietic cell transplantationDyserythropoietic anemiaSole curative optionVeno-occlusive diseaseRetrospective multicenter studyMajority of patientsOutcome of childrenUmbilical cord bloodCDA type IICDA type IAcute graftAggressive chelationChronic GVHDHost diseaseCumulative incidenceCurative optionGraft failureMedian durationNonmyeloablative regimensOverall survival2017 – HUMAN HEMATOPOIETIC STEM CELL ONTOGENY ACROSS DEVELOPMENT AND MATURATION
Rowe G, Li H, Cote P, Kuoch M, Ezike J, Afanassiev A, Greenstreet L, Tarantino G, Zhang S, Whangbo J, Butty V, Moiso E, Falchetti M, Connelly G, Morris V, Wang D, Chen A, Bianchi G, Daley G, Garg S, Liu D, Chou S, Regev A, da Rocha E, Schiebinger G. 2017 – HUMAN HEMATOPOIETIC STEM CELL ONTOGENY ACROSS DEVELOPMENT AND MATURATION. Experimental Hematology 2022, 111: s39-s40. DOI: 10.1016/j.exphem.2022.07.049.Peer-Reviewed Original ResearchHematopoietic stem cellsAcute myeloid leukemiaHuman HSPCsAssociated with poor survivalHematopoietic stem cell stateHuman hematopoietic developmentUmbilical cord bloodAdult bone marrowMature effector cellsLineage-restricted progenitorsBlood diseasesTranscriptional programsCirculating blood cellsCord bloodEngraftment potentialFetal liverEffector cellsHematopoietic stemLymphoid lineagesMyeloid leukemiaHuman hematopoiesisHSPC populationsBone marrowHematopoietic systemPoor survival
2019
Geometric Sketching Compactly Summarizes the Single-Cell Transcriptomic Landscape
Hie B, Cho H, DeMeo B, Bryson B, Berger B. Geometric Sketching Compactly Summarizes the Single-Cell Transcriptomic Landscape. Cell Systems 2019, 8: 483-493.e7. PMID: 31176620, PMCID: PMC6597305, DOI: 10.1016/j.cels.2019.05.003.Peer-Reviewed Original ResearchConceptsSingle-cell transcriptomic landscapeSingle-cell RNA sequencing studiesSingle-cell omicsCell typesSeq data integrationSingle-cell data analysisRare cell typesRNA sequencing studiesScRNA-seq dataTranscriptional diversityTranscriptomic landscapeBiological cell typesTranscriptomic heterogeneitySequencing studiesRare subpopulationAnalysis pipelineCellsUmbilical cord bloodEssential stepInflammatory macrophagesOmicsComprehensive visualizationDiversityGeometric sketchHundreds of thousandsGRFS and CRFS in alternative donor hematopoietic cell transplantation for pediatric patients with acute leukemia
Mehta RS, Holtan SG, Wang T, Hemmer MT, Spellman SR, Arora M, Couriel DR, Alousi AM, Pidala J, Abdel-Azim H, Ahmed I, Aljurf M, Askar M, Auletta JJ, Bhatt V, Bredeson C, Chhabra S, Gadalla S, Gajewski J, Gale RP, Gergis U, Hematti P, Hildebrandt GC, Inamoto Y, Kitko C, Khandelwal P, MacMillan ML, Majhail N, Marks DI, Mehta P, Nishihori T, Olsson RF, Pawarode A, Diaz MA, Prestidge T, Qayed M, Rangarajan H, Ringden O, Saad A, Savani BN, Seo S, Shah A, Shah N, Schultz KR, Solh M, Spitzer T, Szer J, Teshima T, Verdonck LF, Williams KM, Wirk B, Wagner J, Yared JA, Weisdorf DJ. GRFS and CRFS in alternative donor hematopoietic cell transplantation for pediatric patients with acute leukemia. Blood Advances 2019, 3: 1441-1449. PMID: 31053571, PMCID: PMC6517657, DOI: 10.1182/bloodadvances.2018030171.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlemtuzumabBone Marrow CellsChildChild, PreschoolDisease-Free SurvivalFemaleFetal BloodGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansLeukemia, Myeloid, AcuteMalePrecursor Cell Lymphoblastic Leukemia-LymphomaProportional Hazards ModelsRecurrenceSurvival RateThyroglobulinTransplantation ConditioningWhole-Body IrradiationConceptsRelapse-free survivalPediatric patientsGrade IIIBM groupAcute leukemiaHigh riskAlternative donor hematopoietic cell transplantationTotal body irradiation-based conditioningMultivariate analysisDonor hematopoietic cell transplantationFree relapse-free survivalCox proportional hazards modelAnti-thymocyte globulinHematopoietic cell transplantationIrradiation-based conditioningAcute lymphoblastic leukemiaProportional hazards modelUmbilical cord bloodBM recipientsGraft variablesGVHD prophylaxisUCB groupHost diseaseMycophenolate mofetilClinical characteristics
2018
Treatment with Foscarnet after Allogeneic Hematopoietic-Cell Transplant (AlloHCT) Is Associated with Long-Term Loss of Renal Function
Foster Y, Grant M, Thomas S, Cameron B, Raiff D, Corbet K, Ferreri C, Horwitz M. Treatment with Foscarnet after Allogeneic Hematopoietic-Cell Transplant (AlloHCT) Is Associated with Long-Term Loss of Renal Function. Blood 2018, 132: 4594. DOI: 10.1182/blood-2018-99-113189.Peer-Reviewed Original ResearchLong-term renal functionAcute kidney failureAcute kidney injuryChronic kidney diseaseRenal functionChronic GVHDNephrotoxic drugsHuman herpes virus-6 (HHV-6) reactivationAllogeneic hematopoietic cell transplantEnd-stage renal diseaseAlternative donor graftsHHV-6 viremiaUnadjusted median survivalRetrospective cohort studyHematopoietic cell transplantTransplant-related factorsGlomerular filtration rateSerum creatinine valuesMultivariate logistic regressionCKD-EPI equationUmbilical cord bloodManual chart reviewAcute GVHDEGFR declineLower eGFRs
2016
Delivery route determines the presence of immune complexes on umbilical cord erythrocytes
de Lima A, Franco L, Sarmiento A, González J. Delivery route determines the presence of immune complexes on umbilical cord erythrocytes. The Journal Of Maternal-Fetal & Neonatal Medicine 2016, 30: 2647-2652. PMID: 27892735, DOI: 10.1080/14767058.2016.1260116.Peer-Reviewed Original ResearchConceptsUmbilical cord bloodPresence of immune complexesCesarean deliveryCord bloodImmune complexesVaginal deliveryComplement depositionIgM complexesFull-term pregnancyImmunoglobulin complexesInitiate innate immune responsesIgG complexesNewborn variablesInnate immune responseC3d depositionFlow cytometry detectionDelivery samplesCesareanImmune responseBasal levelsBlood samplesUmbilical cord erythrocytesCord erythrocytesIgA complexesDelivery route
2015
Transplant Outcomes for Children with T Cell Acute Lymphoblastic Leukemia in Second Remission: A Report from the Center for International Blood and Marrow Transplant Research
Burke M, Verneris M, Le Rademacher J, He W, Abdel-Azim H, Abraham A, Auletta J, Ayas M, Brown V, Cairo M, Chan K, Diaz Perez M, Dvorak C, Egeler R, Eldjerou L, Frangoul H, Guilcher G, Hayashi R, Ibrahim A, Kasow K, Leung W, Olsson R, Pulsipher M, Shah N, Shah N, Thiel E, Talano J, Kitko C. Transplant Outcomes for Children with T Cell Acute Lymphoblastic Leukemia in Second Remission: A Report from the Center for International Blood and Marrow Transplant Research. Transplantation And Cellular Therapy 2015, 21: 2154-2159. PMID: 26327632, PMCID: PMC4654112, DOI: 10.1016/j.bbmt.2015.08.023.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAcute DiseaseAdolescentBone Marrow TransplantationChildChild, PreschoolChronic DiseaseFemaleGraft vs Host DiseaseHumansImmunosuppressive AgentsInternational CooperationMaleMyeloablative AgonistsPrecursor T-Cell Lymphoblastic Leukemia-LymphomaProspective StudiesRecurrenceRemission InductionSeverity of Illness IndexSurvival AnalysisTransplantation ConditioningTransplantation, HomologousTreatment OutcomeConceptsHematopoietic cell transplantationT-cell acute lymphoblastic leukemiaCell acute lymphoblastic leukemiaMarrow Transplant ResearchAcute lymphoblastic leukemiaInternational BloodLymphoblastic leukemiaTransplant ResearchRelapsed T-cell acute lymphoblastic leukemiaThree-year overall survivalAllogeneic hematopoietic cell transplantationDisease-free survival ratesBone marrow/peripheral bloodTransplant-related mortalitySecond complete remissionBone marrow relapseUmbilical cord bloodPediatric T-ALLChronic graftExtramedullary relapseSecond remissionComplete remissionExtramedullary diseaseHost diseaseMarrow relapse
2010
Regulating human Th17 cells via differential expression of IL-1 receptor (34.7)
Lee W, Kang S, Choi J, Lee S, Shah K, Eynon E, Flavell R, Kang I. Regulating human Th17 cells via differential expression of IL-1 receptor (34.7). The Journal Of Immunology 2010, 184: 34.7-34.7. DOI: 10.4049/jimmunol.184.supp.34.7.Peer-Reviewed Original ResearchIL-17 productionIL-1βT cellsCell differentiationMemory CD4Differential expressionIL-1RITCR triggeringT cell receptor triggeringIL-17IL-15Naive CD4IL-7IL-1 receptor expressionIL-1RI expressionT cell populationsIL-1R antagonistCytokine IL-7Gene expressionIL-1 receptorUmbilical cord bloodReceptor triggeringDistinct CD4Peripheral bloodCord bloodVariations in cord 25‐hydroxyvitamin D levels in Hispanic and Caucasian infants are not related to neonatal bone mineral status
Hicks P, Hawthorne K, Rogers S, Carpenter T, Abrams S. Variations in cord 25‐hydroxyvitamin D levels in Hispanic and Caucasian infants are not related to neonatal bone mineral status. The FASEB Journal 2010, 24: 325.4-325.4. DOI: 10.1096/fasebj.24.1_supplement.325.4.Peer-Reviewed Original ResearchBone mineral statusCaucasian newborn infantsVitamin D statusD levelsNewborn infantsCord bloodInfant vitamin D statusBone mineral content/densityMineral statusVitamin D insufficiencyWhole body BMCUmbilical cord bloodBone mineral outcomesD insufficiencyD statusHispanic infantsInfantsAmerican AcademyAbsorptiometry measurementsFirst weekCaucasian infantsDiaSorin RIAWhole bodyHispanic newbornsBirth
2009
Regulating human Th17 cells via differential expression of IL-1 receptor
Lee WW, Kang SW, Choi J, Lee SH, Shah K, Eynon EE, Flavell RA, Kang I. Regulating human Th17 cells via differential expression of IL-1 receptor. Blood 2009, 115: 530-540. PMID: 19965648, PMCID: PMC2810985, DOI: 10.1182/blood-2009-08-236521.Peer-Reviewed Original ResearchConceptsT cellsIL-1RICell differentiationDifferential expressionIL-17IL-15IL-1betaIL-7T cell receptor triggeringT helper 17 (Th17) cellsIL-1 receptor expressionIL-1RI expressionIL-17 productionHelper 17 cellsT cell populationsCytokine IL-7IL-1R antagonistIL-1 receptorUmbilical cord bloodHuman peripheral bloodGene expressionReceptor triggeringPeripheral bloodCord bloodReceptor expressionComparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/γc−/−, Balb/c-Rag1−/−γc−/−, and C.B-17-scid/bg immunodeficient mice
Lepus CM, Gibson TF, Gerber SA, Kawikova I, Szczepanik M, Hossain J, Ablamunits V, Kirkiles-Smith N, Herold KC, Donis RO, Bothwell AL, Pober JS, Harding MJ. Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/γc−/−, Balb/c-Rag1−/−γc−/−, and C.B-17-scid/bg immunodeficient mice. Human Immunology 2009, 70: 790-802. PMID: 19524633, PMCID: PMC2949440, DOI: 10.1016/j.humimm.2009.06.005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFetal BloodGranulocyte Colony-Stimulating FactorHematopoietic Stem Cell MobilizationHematopoietic Stem Cell TransplantationHematopoietic Stem CellsHemocyaninsHumansHypersensitivity, DelayedImmunoglobulinsInfluenza A Virus, H5N1 SubtypeLiverLymph NodesLymphocyte SubsetsMiceMice, Inbred BALB CMice, Inbred NODMice, KnockoutMice, SCIDRadiation DosageSpleenThymus GlandWhole-Body IrradiationConceptsNOD-scid/Umbilical cord bloodBALB/cHuman fetal liverCord bloodUCB-HSCImmunodeficient miceSecond trimester human fetal liverHematopoietic stem cell preparationsFetal liverTotal human immunoglobulinWhite pulp expansionHumanized mouse modelHematopoietic stem cell engraftmentHuman immune responseHuman immune cellsStem cell engraftmentHuman immune systemHuman T cellsStem cell preparationsDendritic cellsAntigenic challengeDependent antigenPeripheral bloodImmune cells
2007
Neonatal vitamin D status at birth at latitude 32°72′: evidence of deficiency
Basile LA, Taylor SN, Wagner CL, Quinones L, Hollis BW. Neonatal vitamin D status at birth at latitude 32°72′: evidence of deficiency. Journal Of Perinatology 2007, 27: 568-571. PMID: 17625571, DOI: 10.1038/sj.jp.7211796.Peer-Reviewed Original ResearchConceptsVitamin D statusAfrican American infantsD statusCaucasian infantsLow vitamin D statusNeonatal vitamin D statusVitamin D insufficiencySerious public health problemVitamin D deficiencyCord blood samplesPublic health problemUmbilical cord bloodD deficiencyD insufficiencySeason of birthEvidence of deficiencyD levelsCord bloodBlood samplesHealth problemsInfantsCaucasian newbornsBirthCohortStatusCirculating stem cells in extremely preterm neonates
Bizzarro MJ, Bhandari V, Krause DS, Smith BR, Gross I. Circulating stem cells in extremely preterm neonates. Acta Paediatrica 2007, 96: 521-525. PMID: 17391470, DOI: 10.1111/j.1651-2227.2007.00194.x.Peer-Reviewed Original ResearchConceptsWeeks of lifePreterm neonatesNeonatal morbidityPulmonary functionPremature neonatesGestational agePeripheral bloodInitial CD34Median gestational agePulmonary function testsShort-term outcomesUmbilical cord bloodFunction testsNeonatal demographicsBirth weightCord bloodRespiratory diseaseNeonatesCell countCD34Progenitor cellsInverse correlationWeeksBloodMorbidity
2005
Comparison of survival times in a transplant study of hematologic disorders
Fu P, Laughlin MJ, Zhang H. Comparison of survival times in a transplant study of hematologic disorders. Contemporary Clinical Trials 2005, 27: 174-182. PMID: 16326144, DOI: 10.1016/j.cct.2005.10.003.Peer-Reviewed Original ResearchConceptsHuman leucocyte antigenHematologic disordersWilcoxon testUnrelated donor graftsBone marrow transplantationLog-rank testUmbilical cord bloodEvaluation of survivalNeutrophil recoveryDonor graftsOverall survivalMarrow transplantationGraft sourceCancer patientsPatient populationClinical trialsEffective therapyHematologic malignanciesLeucocyte antigenCord bloodLog rankSurvival timePatientsPatient samplesTransplantation studiesAssociation of caffeine metabolites in umbilical cord blood with IUGR and preterm delivery: A prospective cohort study of 1609 pregnancies
Grosso L, Triche E, Belanger K, Benowitz N, Holford T, Bracken M. Association of caffeine metabolites in umbilical cord blood with IUGR and preterm delivery: A prospective cohort study of 1609 pregnancies. Annals Of Epidemiology 2005, 15: 659-660. DOI: 10.1016/j.annepidem.2005.07.037.Peer-Reviewed Original ResearchPreterm deliveryQuartile changeCohort studyCord bloodRatio of paraxanthineProspective cohort studyMethodsProspective cohort studyUmbilical cord bloodSelf-reported caffeine consumptionLogistic regression modelsOne-unit increaseThird trimesterSerum caffeineIUGRUmbilical cordCaffeine exposureReproductive outcomesAssociation of caffeineCaffeine consumptionHealth outcomesCaffeine ratioImportant covariatesRiskOutcomesBlood
1993
Erythropoietin in human fetuses with immune hemolytic anemia and hydrops fetalis.
Moya F, Grannum P, Widness J, Clemons G, Copel J, Hobbins J. Erythropoietin in human fetuses with immune hemolytic anemia and hydrops fetalis. Obstetrics And Gynecology 1993, 82: 353-8. PMID: 8355933.Peer-Reviewed Original ResearchConceptsRh isoimmunizationGestational agePlasma erythropoietinWeeks' gestationElective cesareanControl fetusesImmune hemolytic anemiaUmbilical cord plasmaHigh erythropoietin levelsUmbilical cord bloodCord plasmaLower hemoglobinInverse associationTerm fetusesCord bloodErythropoietin levelsHemolytic anemiaErythropoietin measurementsLate gestationHuman fetusesGestationFetusesIsoimmunizationAnemiaHemoglobin
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