2024
Case report: Tremor in the placebo condition of a blinded clinical trial of intermittent theta-burst stimulation for cocaine use disorder
Steele V, Rotenberg A, Philip N, Hallett M, Stein E, Salmeron B. Case report: Tremor in the placebo condition of a blinded clinical trial of intermittent theta-burst stimulation for cocaine use disorder. Frontiers In Psychiatry 2024, 15: 1391771. PMID: 39045554, PMCID: PMC11263940, DOI: 10.3389/fpsyt.2024.1391771.Peer-Reviewed Original ResearchCocaine use disorderIntermittent theta burst stimulationTheta burst stimulationPlacebo responseUse disorderClinically relevant effectsBlind clinical trialClinical responseNew-onsetPlacebo conditionClinical trialsSham iTBSFunctional disordersPersistent tremorBurst stimulationCocaineDisordersShamStimulationTrialsWeak E-fieldsRelevant effectsTremor
2023
Magnetic Resonance-Guided Focused Ultrasound Thalamotomy Rebalances Atypical Functional Hierarchy in Patients with Essential Tremor
Lin J, Kang X, Lu H, Zhang D, Bian X, Zhou J, Hu J, Zhang D, Sepulcre J, Pan L, Lou X. Magnetic Resonance-Guided Focused Ultrasound Thalamotomy Rebalances Atypical Functional Hierarchy in Patients with Essential Tremor. Neurotherapeutics 2023, 20: 1755-1766. PMID: 37843768, PMCID: PMC10684443, DOI: 10.1007/s13311-023-01442-9.Peer-Reviewed Original ResearchConceptsMRgFUS thalamotomyET patientsEssential tremorMagnetic resonance-guided focused ultrasoundMatched health controlsPostoperative 6 monthsTremor symptomsHealth controlsFunctional MR imagingMRgFUSPatientsFeatures of Parkinson's diseaseThalamotomyRobust alterationsMR imagingPosterior cingulate cortexFocused ultrasoundCingulate cortexSymptomsNeurological diseasesAlterationsParkinson's diseaseSymptom predictionDiseaseTremor
2021
Haploinsufficiency of POU4F1 causes an ataxia syndrome with hypotonia and intention tremor
Webb BD, Evans A, Naidich TP, Bird L, Parikh S, Garcia M, Henderson LB, Millan F, Si Y, Brennand KJ, Hung P, Rucker JC, Wheeler PG, Schadt EE. Haploinsufficiency of POU4F1 causes an ataxia syndrome with hypotonia and intention tremor. Human Mutation 2021, 42: 685-693. PMID: 33783914, PMCID: PMC8162891, DOI: 10.1002/humu.24201.Peer-Reviewed Original ResearchConceptsIntention tremorHead magnetic resonance imagingFunction variantsHypertrophic olivary degenerationCerebellar vermian atrophyMagnetic resonance imagingAtaxia syndromeWhole-exome sequencingVermian atrophyTranscription factor 1Olivary degenerationNervous systemResonance imagingMultiple abnormalitiesFactor 1POU4F1ProbandsSyndromeHypotoniaTremorClass 4De novoIndependent probandsAtrophyNewborns
2019
Enfeeblement in Elders with Essential Tremor: Characterizing the Phenomenon and Its Role in Caregiver Burden
Cersonsky T, Diaz D, Kellner S, Hickman R, Zdrodowska M, Monin J, Louis E. Enfeeblement in Elders with Essential Tremor: Characterizing the Phenomenon and Its Role in Caregiver Burden. Tremor And Other Hyperkinetic Movements 2019, 9 DOI: 10.5334/tohm.461.Peer-Reviewed Original ResearchCaregiver burdenEssential tremorAssessment of patientsCommon movement disorderGreater tremor severityMore depressive symptomsCaregivers of individualsClinical correlatesFunctional impairmentMovement disordersGait disabilityCaregiver needsDepressive symptomsOverall healthTremor severityOlder ageGreater burdenCaregiversTremorBurdenCognitive difficultiesDisabilityScoresEldersIndividuals
2018
Deep Brain Stimulation Management of Essential Tremor with Dystonic Features
Patel A, Deeb W, Okun MS. Deep Brain Stimulation Management of Essential Tremor with Dystonic Features. Tremor And Other Hyperkinetic Movements 2018, 8: 557. PMID: 29971197, PMCID: PMC6026276, DOI: 10.7916/d8p85vbq.Peer-Reviewed Original ResearchConceptsGlobus pallidus internusEssential tremorDystonic featuresSubthalamic targetsDiagnosis of ETDBS target selectionUnilateral DBS implantationDystonic posturingChief complaintDystonic tremorGeneralized dystoniaCase reportDBS implantationDBS targetsVentralis intermediusClinician's choiceDystoniaDBS leadAcceptable optionLimited evidenceTremorOptimal targetingVIMRigorous studiesTargetDeep Brain Stimulation Management of Essential Tremor with Dystonic Features
Patel A, Deeb W, Okun M. Deep Brain Stimulation Management of Essential Tremor with Dystonic Features. Tremor And Other Hyperkinetic Movements 2018, 8: 557. DOI: 10.5334/tohm.426.Peer-Reviewed Original ResearchGlobus pallidus internusEssential tremorDystonic featuresSubthalamic targetsDiagnosis of ETDBS target selectionUnilateral DBS implantationDystonic posturingChief complaintDystonic tremorGeneralized dystoniaCase reportDBS implantationDBS targetsVentralis intermediusClinician's choiceDystoniaDBS leadAcceptable optionLimited evidenceTremorOptimal targetingVIMRigorous studiesTargetBotulinum toxin in essential hand tremor - A randomized double-blind placebo-controlled study with customized injection approach
Mittal SO, Machado D, Richardson D, Dubey D, Jabbari B. Botulinum toxin in essential hand tremor - A randomized double-blind placebo-controlled study with customized injection approach. Parkinsonism & Related Disorders 2018, 56: 65-69. PMID: 29929813, DOI: 10.1016/j.parkreldis.2018.06.019.Peer-Reviewed Original ResearchConceptsHand weaknessEssential hand tremorDouble-blind placebo-controlled studyEssential tremorAdministration of onabotulinumtoxinASevere hand weaknessPlacebo-controlled studyClinical rating scoresHand tremorRating scoresParkinson's disease tremorIncobotulinumtoxinA injectionsCrossover trialPatients' perceptionsBotulinum toxinTreatment efficacyClinical practiceHand strengthForearm musclesTremor severityClinical scalesTremorWeeksTreatmentInjectionCerebello-cortical network fingerprints differ between essential, Parkinson’s and mimicked tremors
Muthuraman M, Raethjen J, Koirala N, Anwar A, Mideksa K, Elble R, Groppa S, Deuschl G. Cerebello-cortical network fingerprints differ between essential, Parkinson’s and mimicked tremors. Brain 2018, 141: 1770-1781. PMID: 29701820, DOI: 10.1093/brain/awy098.Peer-Reviewed Original ResearchConceptsEssential tremorSensorimotor cortexCerebral cortexHealthy controlsPremotor cortexParkinson's diseaseVoluntary rhythmic movementsPrimary sensorimotor cortexSex-matched groupPrimary sensorimotor regionsEEG-EMG coherenceMotor performance measuresParkinson's tremorEMG oscillationsCortical efferentsSensorimotor regionsCerebellar involvementTremor severityFunctional MRICortexCerebellumDiseaseAdditional studiesTremorMulti-channel EMG
2017
Psychological Suffering in Essential Tremor: A Study of Patients and Those Who Are Close to Them
Monin J, Gutierrez J, Kellner S, Morgan S, Collins K, Rohl B, Migliore F, Cosentino S, Huey E, Louis E. Psychological Suffering in Essential Tremor: A Study of Patients and Those Who Are Close to Them. Tremor And Other Hyperkinetic Movements 2017, 7: 526. DOI: 10.5334/tohm.338.Peer-Reviewed Original ResearchNumber of medicationsET patientsEssential tremorTremor severityOverall sufferingCognitive statusPatients’ psychological sufferingNon-motor featuresStudy of patientsPsychological sufferingPatients' cognitive statusOwn depressive symptomsDaily stressPatient depressionDementia patientsDepressive symptomsPatientsPatient experienceMultidisciplinary teamSupportive interventionsMedicationsSeverityRegression modelsTremorDepressionTranscranial MRI‐guided high‐intensity focused ultrasound for treatment of essential tremor: A pilot study on the correlation between lesion size, lesion location, thermal dose, and clinical outcome
Federau C, Goubran M, Rosenberg J, Henderson J, Halpern CH, Santini V, Wintermark M, Pauly K, Ghanouni P. Transcranial MRI‐guided high‐intensity focused ultrasound for treatment of essential tremor: A pilot study on the correlation between lesion size, lesion location, thermal dose, and clinical outcome. Journal Of Magnetic Resonance Imaging 2017, 48: 58-65. PMID: 29076274, DOI: 10.1002/jmri.25878.Peer-Reviewed Original ResearchConceptsMedication-refractory essential tremorClinical outcomesEssential tremorThalamic nucleiLesion volumeLesion sizeAnterior commissure-posterior commissure planeLateral posterior thalamic nucleusPilot studyFinal lesion volumePosterior thalamic nucleusPromising noninvasive methodWilcoxon twoVentral divisionPosttreatment imagesLesion locationYear posttreatmentPosterior commissureScore improvementDoseNoninvasive methodTremorJ. MagnStatistical significanceTechnical efficacyMercury-induced motor and sensory neurotoxicity: systematic review of workers currently exposed to mercury vapor
Fields CA, Borak J, Louis ED. Mercury-induced motor and sensory neurotoxicity: systematic review of workers currently exposed to mercury vapor. Critical Reviews In Toxicology 2017, 47: 815-848. PMID: 28718354, PMCID: PMC5931703, DOI: 10.1080/10408444.2017.1342598.Peer-Reviewed Original ResearchConceptsPhysical examinationMercury workersUrine mercury levelsStudy of neurotoxicityDental cohortNB outcomesSensory neurotoxicityAbnormal reflexesEligible studiesImpaired coordinationNeurobehavioral testsPE findingsNeurological effectsElectrophysiological studiesSystematic reviewNeurotoxicityNB testingManual dexterityNB testsTremorExposureOutcomesHistorical exposureMercury levelsTextbook chapters
2016
Public Knowledge and Attitude toward Essential Tremor: A Questionnaire Survey
Shalaby S, Indes J, Keung B, Gottschalk CH, Machado D, Patel A, Robakis D, Louis ED. Public Knowledge and Attitude toward Essential Tremor: A Questionnaire Survey. Frontiers In Neurology 2016, 7: 60. PMID: 27148160, PMCID: PMC4840213, DOI: 10.3389/fneur.2016.00060.Peer-Reviewed Original ResearchEssential tremorPD patientsDisease patientsFeatures of ETGeneral neurology clinicParkinson's disease patientsConsecutive enrolleesDisease clinicNeurology clinicMain symptomsBrain surgeryPatientsSame diseaseOdd causeEnrolleesTremorClinicPublic knowledgeDiseasePublic awarenessLack of knowledgeGreater awareness
2015
Switching STudy of Kidney TRansplant PAtients with Tremor to LCP‐TacrO (STRATO): an open‐label, multicenter, prospective phase 3b study
Langone A, Steinberg S, Gedaly R, Chan L, Shah T, Sethi K, Nigro V, Morgan J, , Formica R, Barr Y, Brennan D, El‐Amm J, Kozlowski T, Matas A, West‐Thielke P, Kistler K. Switching STudy of Kidney TRansplant PAtients with Tremor to LCP‐TacrO (STRATO): an open‐label, multicenter, prospective phase 3b study. Clinical Transplantation 2015, 29: 796-805. PMID: 26113208, PMCID: PMC4755036, DOI: 10.1111/ctr.12581.Peer-Reviewed Original ResearchConceptsKidney transplant recipientsPhase 3b studyDose reductionKidney transplant patientsPatient Global ImpressionCommon side effectsImmediate-release tacrolimusExtended-release formulationMovement disorder neurologistsFurther dose reductionTransplant recipientsMITT populationStable doseTransplant patientsGlobal ImpressionMarin scaleFahn-TolosaAUC exposureSide effectsPatientsTacrolimusMeaningful improvementsDrug concentrationsSignificant tremorTremorTremor and Klinefelter’s Syndrome
Rabin ML, Mittal SO, Jabbari B. Tremor and Klinefelter’s Syndrome. Tremor And Other Hyperkinetic Movements 2015, 5: 304. PMID: 26175955, PMCID: PMC4473154, DOI: 10.7916/d84m93kr.Peer-Reviewed Original Research
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