2023
Objective response to ethanol in essential tremor: results from a standardized ethanol challenge study
McGurrin P, Norato G, Thompson‐Westra J, McCrossin G, Lines E, Lungu C, Pandey S, Tinaz S, Voller B, Ramchandani V, Hallett M, Haubenberger D. Objective response to ethanol in essential tremor: results from a standardized ethanol challenge study. Annals Of Clinical And Translational Neurology 2023, 11: 156-168. PMID: 38087917, PMCID: PMC10791018, DOI: 10.1002/acn3.51943.Peer-Reviewed Original ResearchObjective responseEthanol administrationEssential tremorSingle-dose challengeThird of patientsPrior ethanol exposureTremor frequencyBreath alcohol levelsMechanism of actionResponder rateEthanol doseBreath alcohol concentrationAcute ethanolEthanol exposureResponder statusAlcohol concentration levelsET patientsChallenge studiesPatientsTremor reductionAlcohol levelsOral ethanolResponse definitionsSecondary analysisTremor severityNo Increased Incidence of Bleeding in Essential Thrombocythemia Patients with Extreme Thrombocytosis
Venkat R, Redd R, Aryee M, Marneth A, Kamaz B, Kim C, Wazir M, Weeks L, Stahl M, DeAngelo D, Lindsley C, Luskin M, Hobbs G, How J. No Increased Incidence of Bleeding in Essential Thrombocythemia Patients with Extreme Thrombocytosis. Blood 2023, 142: 1839. DOI: 10.1182/blood-2023-187530.Peer-Reviewed Original ResearchClinically relevant non-major bleedingTreated with cytoreductionYear cumulative incidenceIncidence of bleedingCumulative incidence of bleedingEssential thrombocythemiaRate of bleedingCumulative incidenceDisease coursePlatelet countThrombotic riskET patientsDiabetes mellitusInitiation of cytoreductive therapyMultivariate analysisActivity levelsIncidence rate of bleedingMultivariable Fine-Gray modelsLow riskRisk factorsInternational Prognostic Score of thrombosisET diagnosisCumulative incidence of thrombosisInternational Society on ThrombosisIncreased incidence of bleedingMagnetic Resonance-Guided Focused Ultrasound Thalamotomy Rebalances Atypical Functional Hierarchy in Patients with Essential Tremor
Lin J, Kang X, Lu H, Zhang D, Bian X, Zhou J, Hu J, Zhang D, Sepulcre J, Pan L, Lou X. Magnetic Resonance-Guided Focused Ultrasound Thalamotomy Rebalances Atypical Functional Hierarchy in Patients with Essential Tremor. Neurotherapeutics 2023, 20: 1755-1766. PMID: 37843768, PMCID: PMC10684443, DOI: 10.1007/s13311-023-01442-9.Peer-Reviewed Original ResearchConceptsMRgFUS thalamotomyET patientsEssential tremorMagnetic resonance-guided focused ultrasoundMatched health controlsPostoperative 6 monthsTremor symptomsHealth controlsFunctional MR imagingMRgFUSPatientsFeatures of Parkinson's diseaseThalamotomyRobust alterationsMR imagingPosterior cingulate cortexFocused ultrasoundCingulate cortexSymptomsNeurological diseasesAlterationsParkinson's diseaseSymptom predictionDiseaseTremorDecreased Synaptic Vesicle Glycoprotein 2A Binding in the Human Postmortem Essential Tremor Cerebellum: Evidence of Reduction in Synaptic Density
Yang Y, Zheng C, Chen B, Hernandez N, Faust P, Cai Z, Louis E, Matuskey D. Decreased Synaptic Vesicle Glycoprotein 2A Binding in the Human Postmortem Essential Tremor Cerebellum: Evidence of Reduction in Synaptic Density. The Cerebellum 2023, 23: 1053-1060. PMID: 37783917, DOI: 10.1007/s12311-023-01611-8.Peer-Reviewed Original ResearchSynaptic vesicle glycoprotein 2AAge-matched controlsSynaptic densityEssential tremorDentate nucleusCerebellar cortexET casesPilot studyLower synaptic densityPrevalent neurological diseaseNumerous degenerative changesNeuropathological alterationsMild atrophyNeuropathological studiesSynaptic markersMethodsThe current studyPostmortem studiesDegenerative changesNeuroimaging signaturesET patientsNeurological diseasesCerebellumEvidence of reductionCortexAtrophy
2020
Deep Brain Stimulation Target Selection in Co-Morbid Essential Tremor and Parkinson’s Disease
Wadhwa A, Schaefer S, Gerrard J, Deeb W, Okun MS, Patel A. Deep Brain Stimulation Target Selection in Co-Morbid Essential Tremor and Parkinson’s Disease. Tremor And Other Hyperkinetic Movements 2020, 10: 17. PMID: 32775031, PMCID: PMC7394224, DOI: 10.5334/tohm.62.Peer-Reviewed Original ResearchConceptsDeep brain stimulationParkinson's diseaseEssential tremorHead trialsDBS targetsAction tremorSubthalamic nucleus (STN) DBSThalamus deep brain stimulationLimited evidenceDBS target selectionVentral intermediate nucleusBilateral STNPD patientsDBS treatmentEquivalent efficacyRest tremorMild improvementCurrent evidenceET patientsET tremorBrain stimulationComparative efficacyPatientsExpert consensusTremor reduction
2019
The Impact of the 2011 European Leukemianet (ELN) Guidelines for Philadelphia Chromosome-Negative Classical Myeloproliferative Neoplasms on Therapeutic Phlebotomy and Hydroxyurea Use in Patients with Polycythemia Vera and Essential Thrombocythemia
Podoltsev N, Wang R, Shallis R, Huntington S, Zeidan A, Gore S, Davidoff A, Ma X. The Impact of the 2011 European Leukemianet (ELN) Guidelines for Philadelphia Chromosome-Negative Classical Myeloproliferative Neoplasms on Therapeutic Phlebotomy and Hydroxyurea Use in Patients with Polycythemia Vera and Essential Thrombocythemia. Blood 2019, 134: 2125. DOI: 10.1182/blood-2019-127563.Peer-Reviewed Original ResearchTherapeutic phlebotomyPopulation-based cohortPV patientsELN guidelinesET patientsPolycythemia veraEssential thrombocythemiaGuideline publicationCelgene CorporationCytoreductive therapyHU useMonthly proportionBoehringer IngelheimLarge population-based cohortAdvisory CommitteeDaiichi SankyoOlder adultsEuropean LeukemiaNet guidelinesEnd Results-MedicareProportion of patientsHealthcare Common Procedure Coding System codesPopulation-based studyPatterns of careTreatment of patientsPart D claims
2018
Use of Statins, Survival and Incidence of Thrombosis Among Older Adults with Essential Thrombocythemia: A Population-Based Study
Podoltsev N, Zhu M, Wang R, Zeidan A, Wang X, Huntington S, Giri S, Davidoff A, Gore S, Ma X. Use of Statins, Survival and Incidence of Thrombosis Among Older Adults with Essential Thrombocythemia: A Population-Based Study. Blood 2018, 132: 4865. DOI: 10.1182/blood-2018-99-119118.Peer-Reviewed Original ResearchUse of statinsIncidence of thrombosisStatin usersLog-rank testRisk of thrombosisOverall survivalEssential thrombocythemiaET diagnosisPercentage of daysHydrophilic statinsOlder adultsET patientsMultivariate Cox proportional hazards modelLarge population-based cohort studyContinuous Medicare Parts APopulation-based cohort studyCox proportional hazards modelEnd Results-MedicareErythropoietin-independent erythroid colony formationBetter overall survivalKaplan-Meier curvesPopulation-based cohortEnd of studyProportional hazards modelPart D
2017
Psychological Suffering in Essential Tremor: A Study of Patients and Those Who Are Close to Them
Monin J, Gutierrez J, Kellner S, Morgan S, Collins K, Rohl B, Migliore F, Cosentino S, Huey E, Louis E. Psychological Suffering in Essential Tremor: A Study of Patients and Those Who Are Close to Them. Tremor And Other Hyperkinetic Movements 2017, 7: 526. DOI: 10.5334/tohm.338.Peer-Reviewed Original ResearchNumber of medicationsET patientsEssential tremorTremor severityOverall sufferingCognitive statusPatients’ psychological sufferingNon-motor featuresStudy of patientsPsychological sufferingPatients' cognitive statusOwn depressive symptomsDaily stressPatient depressionDementia patientsDepressive symptomsPatientsPatient experienceMultidisciplinary teamSupportive interventionsMedicationsSeverityRegression modelsTremorDepression
2016
Mutation analysis of CHCHD2 gene in Chinese Han familial essential tremor patients and familial Parkinson's disease patients
Gao C, Chen Y, Sun Q, He Y, Huang P, Wang T, Li D, Liang L, Liu J, Xiao Q, Chen S. Mutation analysis of CHCHD2 gene in Chinese Han familial essential tremor patients and familial Parkinson's disease patients. Neurobiology Of Aging 2016, 49: 218.e9-218.e11. PMID: 27814991, DOI: 10.1016/j.neurobiolaging.2016.10.001.Peer-Reviewed Original Research
2008
Prevalence of polycythemia vera and essential thrombocythemia
Ma X, Vanasse G, Cartmel B, Wang Y, Selinger HA. Prevalence of polycythemia vera and essential thrombocythemia. American Journal Of Hematology 2008, 83: 359-362. PMID: 18181200, DOI: 10.1002/ajh.21129.Peer-Reviewed Original ResearchConceptsPrevalence of PVPolycythemia veraEssential thrombocythemiaMyeloproliferative disordersUS populationAge-standardized prevalenceHealth claims dataAge-specific prevalenceLarge US populationEntire US populationClaims dataET patientsInsurance payerHealth claimsLogistic regressionPrevalencePatientsMedicaid ServicesMolecular etiologyCommon typeThrombocythemiaDisordersUnited StatesAffected populationVera
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