2025
[18F]SynVesT-1 PET Detects SV2A Changes in the Spinal Cord and Brain of Rats with Spinal Cord Injury
Chen B, Zheng C, Balayeva T, Toyonaga T, Wang X, Tong J, Mennie W, Mihailovic J, Coman D, Hyder F, Strittmatter S, Carson R, Huang Y, Cai Z. [18F]SynVesT-1 PET Detects SV2A Changes in the Spinal Cord and Brain of Rats with Spinal Cord Injury. Journal Of Nuclear Medicine 2025, 66: 1440-1448. PMID: 40675757, PMCID: PMC12410297, DOI: 10.2967/jnumed.124.269291.Peer-Reviewed Original ResearchConceptsSpinal cord injuryDistribution volume ratioDiffusion tensor imagingSpinal cordRat modelDay 1SUV ratioImmunohistochemical stainingSham controlsDay 9PET imagingRat model of spinal cord injuryContusion SCI rat modelSpinal cord injury ratsModel of spinal cord injuryCord injuryWestern blottingModerate contusion injuryBrain of ratsDiffusion tensor imaging analysisPost-mortem spinal cordTraumatic spinal cord injurySCI rat modelSynaptic vesicle glycoprotein 2ACervical cord
2020
Nogo receptor decoy promotes recovery and corticospinal growth in non-human primate spinal cord injury
Wang X, Zhou T, Maynard GD, Terse PS, Cafferty WB, Kocsis JD, Strittmatter SM. Nogo receptor decoy promotes recovery and corticospinal growth in non-human primate spinal cord injury. Brain 2020, 143: 1697-1713. PMID: 32375169, PMCID: PMC7850069, DOI: 10.1093/brain/awaa116.Peer-Reviewed Original ResearchConceptsPrimate spinal cord injurySpinal cord injuryCord injuryFemale African green monkeysTreatment-related adverse eventsChronic neurological deficitsNogo receptor 1Left motor cortexRecovery of functionPreclinical rodent modelsSpinal cord injury animalsAfrican green monkeysRaphespinal fibersAdverse eventsCervical cordNeurological deficitsSurgical complicationsCNS traumaTreatment cessationCorticospinal axonsLumbar catheterInjury animalsNeural recoverySpontaneous feedingLateral hemisection
1987
Cardiovascular abnormalities accompanying acute spinal cord injury in humans: Incidence, time course and severity
Lehmann K, Lane J, Piepmeier J, Batsford W. Cardiovascular abnormalities accompanying acute spinal cord injury in humans: Incidence, time course and severity. Journal Of The American College Of Cardiology 1987, 10: 46-52. PMID: 3597994, DOI: 10.1016/s0735-1097(87)80158-4.Peer-Reviewed Original ResearchConceptsCord injurySpinal cordCardiovascular abnormalitiesAcute spinal cord injuryAcute severe injuryCervical cord injuryPrimary cardiac arrestCervical spinal cordSpinal cord injuryLife-threatening disturbancesMild cervical injuriesPersistent bradycardiaAutonomic imbalanceCervical cordHemodynamic abnormalitiesInjury groupSympathetic pathwaysConsecutive patientsCord traumaCervical injuryAcute injurySupraventricular arrhythmiasCardiac arrestSevere injuriesDay 4
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